{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:41:20Z","timestamp":1791844880566,"version":"4.3.4"},"reference-count":50,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Bras. Dermatol."],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>Several distinct clinical forms of mycosis fungoides have been described. Hypopigmented mycosis fungoides should be regarded as a subtype of mycosis fungoides, insofar as it presents some peculiar characteristics that contrast with the clinical features of the classical form. Most patients with hypopigmented mycosis fungoides are younger than patients typically diagnosed with classical mycosis fungoides. In addition to typical dark-skinned individuals impairment, hypopigmented mycosis fungoides has also been described in Asian patients. The prognosis for hypopigmented mycosis fungoides is much better than for classical mycosis fungoides: hypopigmented mycosis fungoides is diagnosed when there are only patches of affected skin, and lesions usually will not progress beyond terminal stages, although they can persist for many years. Diagnosis should involve clinicopathologic correlation: skin biopsy analysis often reveals intense epidermotropism, characterized by haloed, large, and atypical CD8+ lymphocytes with convoluted nuclei, in contrast to mild to moderate dermal lymphocytic infiltrate. These CD8+ cells, which participate in T helper 1-mediated immune responses, prevent evolution to mycosis fungoides plaques and tumors and could be considered the main cause of the inhibition of melanogenesis. Therefore, hypopigmentation could be considered a marker of good prognosis for mycosis fungoides.<\/jats:p>","DOI":"10.1590\/abd1806-4841.20132336","type":"journal-article","created":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T09:05:22Z","timestamp":1392368722000},"page":"954-960","source":"Crossref","is-referenced-by-count":80,"title":["Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology"],"prefix":"10.1590","volume":"88","author":[{"given":"Fabricio Cecanho","family":"Furlan","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Sanches","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1590\/S0365-05962012000600001","article-title":"Mycosis fungoides and S\u00e9zary syndrome: clinical, histopathological and immunohistochemical review and update","volume":"87","author":"Yamashita T","year":"2012","journal-title":"An Bras Dermatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1001\/archderm.143.7.854","article-title":"Incidence of cutaneous T-cell lymphoma in the United States, 1973-2002","volume":"143","author":"Criscione VD","year":"2007","journal-title":"Arch Dermatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1177\/107327480701400203","article-title":"The diagnosis, staging, and treatment options for mycosis fungoides","volume":"14","author":"Keehn CA","year":"2007","journal-title":"Cancer Control"},{"key":"ref4","first-page":"7","article-title":"Lymphoproliferative processes of the skin. Part 2 - Cutaneous T-cell and NK-cell lymphomas","volume":"87","author":"FestaNeto C","year":"2006","journal-title":"An Bras Dermatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1001\/archderm.1966.01600200077013","article-title":"Pustular mycosis fungoides","volume":"93","author":"Ackerman AB","year":"1966","journal-title":"Arch Dermatol"},{"key":"ref6","first-page":"177","article-title":"Mycosis fungoides","volume":"62","author":"Gordon H","year":"1950","journal-title":"Br J Dermatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/archderm.1977.01640010059009","article-title":"Hyperkeratotic and verrucous features of mycosis fungoides","volume":"113","author":"Price NM","year":"1977","journal-title":"Arch Dermatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1001\/archderm.1971.04000220060011","article-title":"Mycosis fungoidesbullosa","volume":"104","author":"Roenigk HH","year":"1971","journal-title":"Arch Dermatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"S168","DOI":"10.1067\/mjd.2002.107231","article-title":"Invisible mycosis fungoides: a diagnostic challenge","volume":"47","author":"Pujol RM","year":"2002","journal-title":"J Am AcadDermatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1365-2133.1973.tb15444.x","article-title":"Can mycosis fungoides begin in the epidermis? 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hypomelanosis:lessons learned from vitiligo","volume":"19","author":"Singh ZN","year":"2006","journal-title":"Mod Pathol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2310\/7750.2009.08091","article-title":"Mycosis fungoides in the pediatric population: report from an international Childhood Registry of Cutaneous Lymphoma","volume":"14","author":"Pope E","year":"2010","journal-title":"J Cutan Med Surg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1440-0960.2006.00290.x","article-title":"Retrospective 5-year review of 131 patients with mycosis fungoides and S\u00e9zary syndrome seen at the National Skin Centre, Singapore","volume":"47","author":"Tan ES","year":"2006","journal-title":"Australas J Dermatol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1365-4632.2010.04567.x","article-title":"Clinicoepidemiological features of mycosis fungoides in Kuwait, 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hypopigmentation","volume":"8","author":"Goldberg DJ","year":"1986","journal-title":"Am J Dermatopathol"},{"key":"ref34","first-page":"297","article-title":"Fusariosisoccuring in a ulcerated cutaneous CD8+ T cell lymphoma tumor","volume":"16","author":"Hsu CK","year":"2006","journal-title":"Eur J Dermatol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4103\/0378-6323.77456","article-title":"A study of clinicopathologic profile of 15 cases of hypopigmented mycosis fungoides","volume":"77","author":"Khopkar U","year":"2011","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1200\/JCO.2010.32.0630","article-title":"Clinical end points and response criteria in mycosis fungoides and S\u00e9zary syndrome: a consensus statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of the European 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Dermatol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1525-1470.1997.tb00687.x","article-title":"A case of hypopigmented mycosis fungoides in a Young caucasian boy","volume":"14","author":"Di Landro A","year":"1997","journal-title":"Pediatr Dermatol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1365-2133.1982.tb11678.x","article-title":"Hypopigmented mycosis fungoides: report of five cases with ultrastructural observations","volume":"106","author":"Breathnach SM","year":"1982","journal-title":"Br J Dermatol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1046\/j.1365-2133.2000.03851.x","article-title":"Leucoderma associated with flares of erythrodermic cutaneous T-cell lymphomas:four cases","volume":"143","author":"Bouloc A","year":"2000","journal-title":"Br J 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vitiligo and other hypopigmented disorders: suggestive possible therapeutic targets","volume":"27","author":"Seif El Nasr H","year":"2013","journal-title":"J EurAcadDermatolVenereol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/path.1538","article-title":"Mechanisms underlying the dysfunction of melanocytes in vitiligo epidermis: role of SCF\/KIT protein interactions and the downstream effector","volume":"202","author":"Kitamura R","year":"2004","journal-title":"J Pathol"},{"key":"ref48","first-page":"40","article-title":"Mycosis fungoides: epidemiologic study of 17 cases and evaluation of PUVA photochemotherapy","volume":"81","author":"Duarte I","year":"2006","journal-title":"An Bras Dermatol"},{"key":"ref49","first-page":"493","article-title":"Hypopigmented mycosis fungoides associated with atopy in two children","volume":"23","author":"Onsun 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