{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:08:06Z","timestamp":1785708486775,"version":"3.56.0"},"reference-count":6,"publisher":"FapUNIFESP (SciELO)","issue":"6 suppl 1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Bras. Dermatol."],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>A 57-year-old woman presented with periorbital ecchymoses, laxity in skin folds, polyneuropathy and bilateral carpal tunnel syndrome. A skin biopsy of the axillary lesion demonstrated fragmentation of elastic fibers, but with a negative von Kossa stain, consistent with cutis laxa. The diagnosis of primary systemic amyloidosis was made by the presence of amyloid material in the eyelid using histopathological techniques, besides this, the patient was also diagnosed with purpura, polyneuropathy, bilateral carpal tunnel syndrome and monoclonal gammopathy. She was diagnosed as suffering from multiple myeloma based on the finding of 40% plasma cells in the bone marrow, component M in the urine and anemia. The patient developed blisters with a clear content, confirmed as mucinosis by the histopathological exam. The final diagnoses were: primary systemic amyloidosis, acquired cutis laxa and mucinosis, all related to multiple myeloma.<\/jats:p>","DOI":"10.1590\/abd1806-4841.20132531","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T19:47:08Z","timestamp":1391111228000},"page":"32-35","source":"Crossref","is-referenced-by-count":16,"title":["Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma"],"prefix":"10.1590","volume":"88","author":[{"given":"Fernanda Guedes","family":"Lavorato","sequence":"first","affiliation":[{"name":"Rio de Janeiro State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de F\u00e1tima Guimar\u00e3es Scotelaro","family":"Alves","sequence":"additional","affiliation":[{"name":"Rio de Janeiro State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel Pi\u00f1eiro","family":"Maceira","sequence":"additional","affiliation":[{"name":"Rio de Janeiro Federal University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Unterstell","sequence":"additional","affiliation":[{"name":"Rio de Janeiro State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Ara\u00fajo","family":"Serpa","sequence":"additional","affiliation":[{"name":"Rio de Janeiro State University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luna","family":"Azulay-Abulafia","sequence":"additional","affiliation":[{"name":"Rio de Janeiro State University; Gama Filho University,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","first-page":"114","article-title":"Acquired cutis laxa associated with multiple myeloma","volume":"69","author":"Gupta A","year":"2002","journal-title":"Cutis"},{"key":"ref2","first-page":"267","article-title":"Cutis laxa acquisita associated with multiple myeloma: a case report and review of the literature","volume":"57","author":"McCarty MJ","year":"1996","journal-title":"Cutis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0001-7310(05)73042-8","article-title":"Amiloidosis sist\u00e9micas (<em>Systemic amyloidosis<\/em>)","volume":"96","author":"Alvarez-Ruiz SB","year":"2005","journal-title":"Actas Dermosifiliogr"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1590\/S0365-05962012000100015","article-title":"Primary systemic amyloidosis associated with multiple myeloma","volume":"87","author":"Oliveira EV","year":"2012","journal-title":"An Bras Dermatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1346-8138.1989.tb01221.x","article-title":"Coexistence of papular mucinosis and systemic amyloidosis associated with lambda-type IgD paraproteinemia","volume":"16","author":"Ishibashi A","year":"1989","journal-title":"J Dermatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1076\/orbi.18.1.53.2722","article-title":"Surgical correction of entropion and excess upper eyelid skin in congenital cutis laxa: a case report","volume":"18","author":"Shah-Desai SD","year":"1999","journal-title":"Orbit"}],"container-title":["Anais Brasileiros de Dermatologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abd\/v88n6s1\/0365-0596-abd-88-06-s1-0032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T15:00:41Z","timestamp":1747666841000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0365-05962013000800032&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":6,"journal-issue":{"issue":"6 suppl 1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0365-05962013000800032"],"URL":"https:\/\/doi.org\/10.1590\/abd1806-4841.20132531","relation":{},"ISSN":["0365-0596"],"issn-type":[{"value":"0365-0596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}