{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:06:48Z","timestamp":1793232408066,"version":"4.5.0"},"reference-count":38,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Bras. Dermatol."],"DOI":"10.1590\/abd1806-4841.20186972","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T19:32:14Z","timestamp":1530127934000},"page":"323-331","source":"Crossref","is-referenced-by-count":130,"title":["Tuberous sclerosis complex: review based on new diagnostic criteria"],"prefix":"10.1590","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3357-1013","authenticated-orcid":false,"given":"Larissa Karine Leite","family":"Portocarrero","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5920-8186","authenticated-orcid":false,"given":"Kl\u00edcia Novais","family":"Quental","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-8553","authenticated-orcid":false,"given":"Luciana Paula","family":"Samorano","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8596-1999","authenticated-orcid":false,"given":"Zilda Najjar Prado de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-7330","authenticated-orcid":false,"given":"Maria Cec\u00edlia da Matta","family":"Rivitti-Machado","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2018,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1590\/S0365-05962012000200001","article-title":"Tuberous sclerosis complex","volume":"87","author":"Rodrigues DA","year":"2012","journal-title":"An Bras Dermatol"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.001493","article-title":"Cardiovascular manifestations of tuberous sclerosis complex and summary of the revised diagnostic criteria and surveillance and management recommendations from the International Tuberous Sclerosis Consensus Group","volume":"3","author":"Hinton RB","year":"2014","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pediatrneurol.2013.08.001","article-title":"Tuberous sclerosis complex diagnostic criteria update: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference","volume":"49","author":"Northrup H","year":"2013","journal-title":"Pediatr Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/jdv.13356","article-title":"Systemic effects of treatment with mTOR inhibitors in tuberous sclerosis complex: a comprehensive review","volume":"30","author":"Sadowski K","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.pcl.2015.03.005","article-title":"Tuberous SclerosisComplex","volume":"62","author":"DiMario Jr FJ","year":"2015","journal-title":"Pediatr Clin North Am"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/pde.12567","article-title":"Tuberous Sclerosis Complex: An Update for Dermatologists","volume":"32","author":"Jacks SK","year":"2015","journal-title":"Pediatr Dermatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1093\/neuonc\/nov152","article-title":"Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous sclerosis complex","volume":"17","author":"MacKeigan JP","year":"2015","journal-title":"Neuro Oncol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/archdischild-2013-304948","article-title":"Annual review of children with tuberous sclerosis","volume":"100","author":"Ng KH","year":"2015","journal-title":"Arch Dis Child Educ Pract Ed"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/GIM.0b013e31803068c7","article-title":"Genotype\/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States","volume":"9","author":"Au KS","year":"2007","journal-title":"Genet Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1177\/0883073813488664","article-title":"A novel topical rapamycin cream for the treatment of facial angiofibromas in tuberous sclerosis complex","volume":"28","author":"Wheless JW","year":"2013","journal-title":"J Child Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1001\/archdermatol.2010.125","article-title":"Topical rapamycin: a novel approach to facial angiofibromas in tuberous sclerosis","volume":"146","author":"Haemel AK","year":"2010","journal-title":"Arch Dermatol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/jdv.12665","article-title":"Analysis of current data on the use of topical rapamycin in the treatment of facial angiofibromas in tuberous sclerosis complex","volume":"29","author":"Balestri R","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2165\/11634580-000000000-00000","article-title":"Topical rapamycin therapy to alleviate the cutaneous manifestations of tuberous sclerosis complex: a double-blind, randomized, controlled trial to evaluate the safety and efficacy of topically applied rapamycin","volume":"12","author":"Koenig MK","year":"2012","journal-title":"Drugs R D"},{"key":"ref14","first-page":"165","article-title":"Topical rapamycin solution to treat multiple facial angiofibromas in a patient with tuberous sclerosis","volume":"103","author":"Valer\u00f3n-Almaz\u00e1n P","year":"2012","journal-title":"Actas Dermosifiliogr"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13023-014-0182-9","article-title":"TOSCA - first international registry to address knowledge gaps in the natural history and management of tuberous sclerosis complex","volume":"9","author":"Kingswood JC","year":"2014","journal-title":"Orphanet J Rare Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.eururo.2016.01.048","article-title":"Natural History of Renal Angiomyolipoma (AML): Most Patients with Large AMLs &gt; 4cm Can Be Offered Active Surveillance as an Initial Management Strategy","volume":"70","author":"Bhatt JR","year":"2016","journal-title":"Eur Urol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/path.4827","article-title":"New developments in the genetics and pathogenesis of tumours in tuberous sclerosis complex","volume":"241","author":"Lam HC","year":"2017","journal-title":"J Pathol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"E507","DOI":"10.5489\/cuaj.2532","article-title":"Composite renal cell carcinoma and angiomyolipoma in a patient with Tuberous sclerosis: A diagnostic dilema","volume":"9","author":"Kakkar A","year":"2015","journal-title":"Can Urol Assoc J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1474-4422(15)00069-1","article-title":"Neurological and neuropsychiatric aspects of tuberous sclerosis complex","volume":"14","author":"Curatolo P","year":"2015","journal-title":"Lancet Neurol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"32","DOI":"10.15844\/pedneurbriefs-30-7-1","article-title":"Tuberous sclerosis complex: a roadmap for future research","volume":"30","author":"Jeong A","year":"2016","journal-title":"Pediatr Neurol Briefs"},{"key":"ref21","first-page":"49255","article-title":"Tuberous sclerosis complex surveillance and management: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference","author":"Krueger DA","year":"2013","journal-title":"Pediatr Neurol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/lsm.20939","article-title":"New Technique Using Combined Pulsed Dye Laser and Fractional Resurfacing for Treating Facial Angiofibromas in Tuberous Sclerosis","volume":"42","author":"Weiss ET","year":"2010","journal-title":"Lasers Surg Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1073\/pnas.0712397105","article-title":"Mesenchymal-epithelial interactions involving epiregulin in tuberous sclerosis complex hamaratomas","volume":"105","author":"Li S","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1158\/1078-0432.CCR-11-0445","article-title":"Sirolimus therapy for angiomyolipoma in tuberous sclerosis and sporadic lymphangioleiomyomatosis: a phase 2 trial","volume":"17","author":"Davies DM","year":"2011","journal-title":"Clin Cancer Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/ana.24523","article-title":"Everolimus for subependymal giant cell astrocytoma: 5-year final analysis","volume":"78","author":"Franz DN","year":"2015","journal-title":"Ann Neurol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1016\/S0140-6736(16)31419-2","article-title":"Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study","volume":"388","author":"French JA","year":"2016","journal-title":"Lancet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0140-6736(12)61134-9","article-title":"Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial","volume":"381","author":"Franz DN","year":"2013","journal-title":"Lancet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0140-6736(12)61767-X","article-title":"Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial","volume":"381","author":"Bissler JJ","year":"2013","journal-title":"Lancet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13023-016-0553-5","article-title":"Tuberous Sclerosis registry to increase disease Awareness (TOSCA) - baseline data on 2093 patients","volume":"12","author":"Kingswood JC","year":"2017","journal-title":"Orphanet J Rare Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ejpn.2013.03.002","article-title":"Long-term effect of everolimus on epilepsy and growth in children under 3 years of age treated for subependymal giant cell astrocytoma associated with tuberous sclerosis complex","volume":"17","author":"Kotulska K","year":"2013","journal-title":"Eur J Paediatr Neurol"},{"key":"ref31","series-title":"Afinitor. Drug leaflet"},{"key":"ref32","series-title":"Rapamune. Drug leaflet"},{"key":"ref33","first-page":"73802","article-title":"Improvement of tuberous sclerosis complex skin tumors during long-term treatment with oral sirolimus","author":"Nathan N","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/1756287216641353","article-title":"Optimal treatment of tuberous sclerosis complex associated renal angiomyolipomata: a systematic review","volume":"8","author":"Bissler JJ","year":"2016","journal-title":"Ther Adv Urol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/iub.1579","article-title":"Tuberous Sclerosis Complex: From Molecular Biology to Novel Therapeutic Approaches","volume":"68","author":"Switon K","year":"2016","journal-title":"IUBMB Life"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e239","DOI":"10.1542\/peds.2012-3607","article-title":"Possible prevention of tuberous sclerosis complex lesions","volume":"132","author":"Kotulska K","year":"2013","journal-title":"Pediatrics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1590\/S0365-05962012000500004","article-title":"Assessment of the quality of life of pediatric patients at a center of excellence in dermatology in southern Brazil","volume":"87","author":"Weber MB","year":"2012","journal-title":"An Bras Dermatol"},{"key":"ref38","first-page":"52","article-title":"Evaluation of the quality of life and psychological distress of patients with different dermatoses in a dermatology referral center in southern Brazil","volume":"85","author":"Taborda ML","year":"2010","journal-title":"An Bras Dermatol"}],"container-title":["Anais Brasileiros de Dermatologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abd\/v93n3\/0365-0596-abd-93-03-0323.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T15:00:45Z","timestamp":1747666845000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0365-05962018000300323&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,6]]}},"alternative-id":["S0365-05962018000300323"],"URL":"https:\/\/doi.org\/10.1590\/abd1806-4841.20186972","relation":{},"ISSN":["1806-4841","0365-0596"],"issn-type":[{"value":"1806-4841","type":"electronic"},{"value":"0365-0596","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]}}}