{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T02:43:19Z","timestamp":1761619399283,"version":"3.40.5"},"reference-count":14,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An. Bras. Dermatol."],"DOI":"10.1590\/abd1806-4841.20186982","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T20:08:38Z","timestamp":1532981318000},"page":"529-534","source":"Crossref","is-referenced-by-count":8,"title":["Ingenol mebutate in the treatment of actinic keratoses: clearance rate and adverse effects"],"prefix":"10.1590","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5043-489X","authenticated-orcid":false,"given":"Maria Isabel Ramos","family":"Saraiva","sequence":"first","affiliation":[{"name":"Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo,  Brazil; Hospital Alem\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3357-1013","authenticated-orcid":false,"given":"Larissa Karine Leite","family":"Portocarrero","sequence":"additional","affiliation":[{"name":"Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2892-9922","authenticated-orcid":false,"given":"Marcella Amaral Horta Barbosa","family":"Vieira","sequence":"additional","affiliation":[{"name":"Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2201-5628","authenticated-orcid":false,"given":"Bethania Cabral Cavalli","family":"Swiczar","sequence":"additional","affiliation":[{"name":"Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4256-208X","authenticated-orcid":false,"given":"Andrezza Telles","family":"Westin","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.jaad.2012.10.001","article-title":"The importance of early diagnosis and treatment of actinic keratosis","volume":"68","author":"Rigel DS","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1590\/S0365-05962012000300012","article-title":"Actinic keratosis: a clinical and epidemiological revision","volume":"87","author":"Schmitt JV","year":"2012","journal-title":"An Bras Dermatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1365-2133.2006.07692.x","article-title":"Guidelines for the management of actinic keratoses","volume":"156","author":"de Berker D","year":"2007","journal-title":"Br J Dermatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s13555-014-0049-y","article-title":"Actinic keratosis: rationale and management","volume":"4","author":"Dodds A","year":"2014","journal-title":"Dermatol Ther (Heidelb)"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3315\/jdcr.2015.1199","article-title":"How to treat actinic keratosis An update","volume":"9","author":"Costa C","year":"2015","journal-title":"J Dermatol Case Rep"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1111\/dsu.12233","article-title":"A pilot split-face study comparing conventional methyl aminolevulinate-photodynamic therapy (PDT) with microneedling-assisted PDT on actinically damaged skin","volume":"39","author":"Torezan L","year":"2013","journal-title":"Dermatol Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jaad.2006.07.021","article-title":"Erythroplasia of Queyrat treated with imiquimod 5% cream","volume":"55","author":"Micali G","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1056\/NEJMoa1111170","article-title":"Ingenol mebutate gel for actinic keratosis","volume":"366","author":"Lebwohl M","year":"2012","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jaad.2009.01.008","article-title":"Randomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0 025% and 0.05% for actinic keratosis","volume":"60","author":"Anderson L","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2340\/00015555-2167","article-title":"New Topical Treatment Options for Actinic Keratosis: A Systematic Review","volume":"96","author":"Stockfleth E","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"ref11","first-page":"CD004415","article-title":"Interventions for actinic keratoses","volume":"12","author":"Gupta AK","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/j.1468-3083.2009.03259.x","article-title":"Intraindividual, right-left comparison of topical 5-aminolevulinic acid photodynamic therapy vs 5% imiquimod cream for actinic keratoses on the upper extremities","volume":"23","author":"Sotiriou E","year":"2009","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1111\/jdv.13063","article-title":"Evaluation of the tolerability and safety of a 0.015% ingenol mebutate gel compared to 5% 5-fluorouracil cream for the treatment of facial actinic keratosis: a prospective randomized trial","volume":"29","author":"Samorano LP","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/j.jaad.2012.09.050","article-title":"Clinical findings using ingenol mebutate gel to treat actinic keratoses","volume":"68","author":"Martin G","year":"2013","journal-title":"J Am Acad Dermatol"}],"container-title":["Anais Brasileiros de Dermatologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abd\/v93n4\/0365-0596-abd-93-04-0529.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T15:00:45Z","timestamp":1747666845000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0365-05962018000400006&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,8]]}},"alternative-id":["S0365-05962018000400006"],"URL":"https:\/\/doi.org\/10.1590\/abd1806-4841.20186982","relation":{},"ISSN":["1806-4841","0365-0596"],"issn-type":[{"type":"electronic","value":"1806-4841"},{"type":"print","value":"0365-0596"}],"subject":[],"published":{"date-parts":[[2018,8]]}}}