{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:55:43Z","timestamp":1787504143477,"version":"build-2736575974"},"reference-count":40,"publisher":"FapUNIFESP (SciELO)","issue":"8","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"DOI":"10.1590\/acb360802","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T02:58:00Z","timestamp":1633834680000},"source":"Crossref","is-referenced-by-count":17,"title":["Atractylenolide III alleviates sepsis-mediated lung injury via inhibition of FoxO1 and VNN1 protein"],"prefix":"10.1590","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5812-838X","authenticated-orcid":false,"given":"Ji-ding","family":"Fu","sequence":"first","affiliation":[{"name":"Institute of Guangzhou Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5238-5972","authenticated-orcid":false,"given":"Chun-hui","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Guangzhou Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7506-5779","authenticated-orcid":false,"given":"Shi-wei","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Guangzhou Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5104-8117","authenticated-orcid":false,"given":"Yan","family":"Tian","sequence":"additional","affiliation":[{"name":"Institute of Guangzhou Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4369-7376","authenticated-orcid":false,"given":"Shi-cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Guangzhou Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1533-1190","authenticated-orcid":false,"given":"Yi-er","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Guangzhou Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-1654","authenticated-orcid":false,"given":"Le-wu","family":"Xian","sequence":"additional","affiliation":[{"name":"Institute of Guangzhou Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2021]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4161\/viru.27372","article-title":"Epidemiology of severe sepsis","volume":"5","author":"Mayr FB","year":"2014","journal-title":"Virulence"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/SHK.0b013e31826359d0","article-title":"Lung endothelial cell apoptosis during ischemic acute kidney injury","volume":"38","author":"White LE","year":"2012","journal-title":"Shock"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bpa.2003.12.007","article-title":"Inflammation and the acute respiratory distress syndrome","volume":"18","author":"Crimi E","year":"2004","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"L1245","DOI":"10.1152\/ajplung.00453.2001","article-title":"Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice","volume":"282","author":"Maus UA","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1001\/jama.2011.438","article-title":"Management of sepsis","volume":"305","author":"Angus J","year":"2011","journal-title":"J Am Med Assoc"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000","volume":"348","author":"Martin GS","year":"2003","journal-title":"N Engl J Med."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3109\/13880209.2012.742116","article-title":"Protective effect of curcumin against cardiac dysfunction in sepsis rats","volume":"51","author":"Yang C","year":"2013","journal-title":"Pharm Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jinf.2011.08.004","article-title":"New concepts in the pathogenesis, diagnosis and treatment of bacteremia and sepsis","volume":"63","author":"Huttunen R","year":"2011","journal-title":"J Infect"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1053\/j.ackd.2012.10.013","article-title":"Sepsis: update in the management","volume":"20","author":"Venkataraman R","year":"2013","journal-title":"Adv Chronic Kidney Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jep.2012.12.013","article-title":"Naturally derived anti-inflammatory compounds from Chinese medicinal plants","volume":"146","author":"Wang Q","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jep.2007.08.002","article-title":"Screening for the anti-inflammatory activity of fractions and compounds from Atractylodes macrocephala koidz","volume":"114","author":"Li CQ","year":"2007","journal-title":"J Ethnopharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"R114","DOI":"10.1186\/cc9063","article-title":"Hypervolemia induces and potentiates lung damage after recruitment maneuver in a model of sepsis-induced acute lung injury","volume":"14","author":"Silva PL","year":"2010","journal-title":"Crit Care"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1007\/s11064-014-1370-7","article-title":"Neuroprotection of atractylenolide III from Atractylodis macrocephalae against glutamate-induced neuronal apoptosis via inhibiting caspase signaling pathway","volume":"39","author":"Liu C","year":"2014","journal-title":"Neurochem Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.fct.2017.05.042","article-title":"Ameliorative effect of atractylenolide III in the mast cell proliferation induced by TSLP","volume":"106","author":"Yoou MS","year":"2017","journal-title":"Food Chem Toxicol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1615\/JEnvironPatholToxicolOncol.2019029196","article-title":"Atractylenolide III enhances the anti-neoplastic efficacy of docetaxel in gastric cancer cell by inhibiting fibroblast growth factor receptors 1, -2, and -4 expression","volume":"38","author":"Ji Y","year":"2019","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1248\/cpb.c15-00805","article-title":"Inflammatory inhibitory activity of sesquiterpenoids from Atractylodes macrocephala Rhizomes","volume":"64","author":"Hoang le","year":"2016","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"ref17","first-page":"1875471","article-title":"Atractylenolide III attenuates muscle wasting in chronic kidney disease via the oxidative stress-mediated PI3K\/AKT\/mTOR pathway","volume":"2019","author":"Wang M","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1615\/JEnvironPatholToxicolOncol.2019029196","article-title":"Atractylenolide III enhances the anti-neoplastic efficacy of docetaxel in gastric cancer cell by inhibiting fibroblast growth factor receptors 1, -2, and -4 expression","volume":"38","author":"Ji Y","year":"2019","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.neuroscience.2015.01.060","article-title":"Neuroprotection and mechanisms of atractylenolide III in preventing learning and memory impairment induced by chronic high-dose homocysteine administration in rats","volume":"290","author":"Zhao H","year":"2015","journal-title":"Neuroscience"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1194\/jlr.M065565","article-title":"VNN1 promotes atherosclerosis progression in apoE-\/- mice fed a high-fat\/high-cholesterol diet","volume":"57","author":"Hu YW","year":"2016","journal-title":"J Lipid Res"},{"key":"ref21","first-page":"4455","article-title":"VNN1 overexpression is associated with poor response to preoperative chemoradiotherapy and adverse prognosis in patients with rectal cancers","volume":"8","author":"Chai CY","year":"2016","journal-title":"Am J Transl Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/09537104.2013.809520","article-title":"Ticagrelor reduces neutrophil recruitment and lung damage in abdominal sepsis","volume":"25","author":"Rahman M","year":"2011","journal-title":"Platelets"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/SHK.0b013e3182144935","article-title":"Targeting CD44 expressed on neutrophils inhibits lung damage in abdominal sepsis","volume":"35","author":"Hasan Z","year":"2011","journal-title":"Shock"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10863-020-09842-8","article-title":"miR-128-3p enhances the protective effect of dexmedetomidine on acute lung injury in septic mice by targeted inhibition of MAPK14","volume":"52","author":"Ding L","year":"2020","journal-title":"J Bioenerg Biomembr"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00011-020-01316-2","article-title":"Down-regulation of lncRNA CASC9 aggravates sepsis-induced acute lung injury by regulating miR-195-5p\/PDK4 axis","volume":"69","author":"Wang HR","year":"2020","journal-title":"Inflamm Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1164\/ajrccm.166.11.340","article-title":"Meta-analysis of acute lung injury and acute respiratory distress syndrome trials","volume":"166","author":"Brower RG","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1007\/s10753-014-9893-2","article-title":"Remifentanil attenuates lipopolysaccharide-induced acute lung injury by downregulating the NF-\u03baB signaling pathway","volume":"37","author":"Zhang Y","year":"2014","journal-title":"Inflammation"},{"key":"ref28","first-page":"261","article-title":"Plasma levels of TNF-alpha, endothelin-1 and thrombomodulin in patients with sepsis","volume":"84","author":"Takakuwa T","year":"1994","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/stem.1632","article-title":"Interleukin 6 mediates the therapeutic effects of adipose-derived stromal\/stem cells in lipopolysaccharide-induced acute lung injury","volume":"32","author":"Zhang S","year":"2014","journal-title":"Stem Cells"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/sur.2006.018","article-title":"Apoptotic death of renal tubular cells in experimental sepsis","volume":"9","author":"Messaris E","year":"2008","journal-title":"Surg Infect (Larchmt)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.surg.2007.04.005","article-title":"Polymicrobial sepsis enhances clearance of apoptotic immune cells by splenic macrophages","volume":"142","author":"Swan R","year":"2007","journal-title":"Surgery"},{"key":"ref32","first-page":"S73","article-title":"Enhanced phagocytosis of apoptotic immune cells by splenic marginal zone macrophages during polymicrobial sepsis","volume":"56","author":"Swan R","year":"2007","journal-title":"Inflamm Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1159\/000500484","article-title":"MicroRNA-203 Acts as a potent suppressor in septic shock by alleviating lung injury via inhibition of VNN1","volume":"44","author":"Ling L","year":"2019","journal-title":"Kidney Blood Press Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1002\/ijc.28855","article-title":"A novel transcript, VNN1-AB, as a biomarker for colorectal cancer","volume":"135","author":"L\u00f8vf M","year":"2014","journal-title":"Int J Cancer"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"7410","DOI":"10.1038\/sj.onc.1209086","article-title":"FOXO transcription factors at the interface between longevity and tumor suppression","volume":"24","author":"Greer EL","year":"2005","journal-title":"Oncogene"},{"key":"ref36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059726","article-title":"PPAR\u03b2\/\u03b4 regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting","volume":"8","author":"Castillero E","year":"2013","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1002\/stem.2274","article-title":"TNF-\u03b1 inhibits FoxO1 by upregulating miR-705 to aggravate oxidative damage in bone marrow-derived mesenchymal stem cells during osteoporosis","volume":"34","author":"Liao L","year":"2016","journal-title":"Stem Cells"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e230","DOI":"10.1097\/CCM.0000000000000993","article-title":"Drug repurposing screen identifies Foxo1-dependent angiopoietin-2 regulation in sepsis","volume":"43","author":"Ghosh CC","year":"2015","journal-title":"Crit Care Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1249\/01.MSS.0000389379.80181.6e","article-title":"Foxo signaling is required for muscle atrophy associated with sepsis","volume":"42","author":"Judge AR","year":"2010","journal-title":"Med Sci Sports Exercise"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s10495-013-0833-7","article-title":"SIRT1 inhibits TNF-\u03b1-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1","volume":"18","author":"Wang W","year":"2013","journal-title":"Apoptosis"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T02:58:34Z","timestamp":1633834714000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502021000800201&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021]]}},"alternative-id":["S0102-86502021000800201"],"URL":"https:\/\/doi.org\/10.1590\/acb360802","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"article-number":"e360802"}}