{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:15:25Z","timestamp":1753888525630,"version":"3.41.2"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"8","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"DOI":"10.1590\/acb360805","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T06:55:00Z","timestamp":1633848900000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of mesalazine polymeric conjugate in the treatment of actinic proctitis in rats"],"prefix":"10.1590","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4420-6962","authenticated-orcid":false,"given":"Vin\u00edcius Rodrigues Taranto","family":"Nunes","sequence":"first","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7003-5159","authenticated-orcid":false,"given":"Paula Vieira Teixeira","family":"Vidigal","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-9691","authenticated-orcid":false,"given":"M\u00e1rcio Tadeu","family":"Pereira","sequence":"additional","affiliation":[{"name":"Centro de Desenvolvimento da Tecnologia Nuclear,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2887-962X","authenticated-orcid":false,"given":"Lu\u00eds Carlos Duarte","family":"Ladeira","sequence":"additional","affiliation":[{"name":"Centro de Desenvolvimento da Tecnologia Nuclear,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8354-8407","authenticated-orcid":false,"given":"Marcelo Vidigal","family":"Caliari","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9963-1758","authenticated-orcid":false,"given":"Fabr\u00edcio Marcus Silva","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8067-1810","authenticated-orcid":false,"given":"Aina Liz Alves","family":"Cesar","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-6158","authenticated-orcid":false,"given":"Andr\u00e9 Augusto Gomes","family":"Faraco","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6488-734X","authenticated-orcid":false,"given":"Rafael Calv\u00e3o","family":"Barbuto","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0510-3506","authenticated-orcid":false,"given":"Ivana","family":"Duval-Araujo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2021]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1067\/j.cpsurg.2013.04.004","article-title":"Gastrointestinal complications of pelvic radiotherapy: medical and surgical management strategies","volume":"50","author":"Hogan NM","year":"2013","journal-title":"Curr Probl Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1748-717X-5-22","article-title":"Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis","volume":"5","author":"Ong ZY","year":"2010","journal-title":"Radiat Oncol"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.ijrobp.2007.08.051","article-title":"Glucagon-like peptide-2 improves both acute and late experimental radiation enteritis in the rat","volume":"69","author":"Torres S","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"272","DOI":"10.5306\/wjco.v6.i6.272","article-title":"Pelvic radiation disease: updates on treatment options","volume":"6","author":"Frazzoni L","year":"2015","journal-title":"World J ClinOncol"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1046\/j.1365-2036.2001.01075.x","article-title":"Review article: current therapeutic options for radiation proctopathy","volume":"15","author":"Hong JJ","year":"2001","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"ref6","first-page":"940","article-title":"Prophylactic and therapeutic effects of oral budesonide for acute radiation-induced enteritis and colitis in rats","volume":"7","author":"Odabasi M","year":"2014","journal-title":"Int J Clin Exp Med"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1007\/s10620-011-1637-7","article-title":"The efficacy of the combination therapy with oral and topical mesalazine for patients with the first episode of radiation proctitis","volume":"56","author":"Seo EH","year":"2011","journal-title":"Dig Dis Sci"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejps.2017.09.037","article-title":"New mesalamine polymeric conjugate for controlled release: preparation, characterization and biodistribution study","volume":"111","author":"Cesar ALA","year":"2018","journal-title":"Eur J Pharm Sci"},{"issue":"16","key":"ref9","doi-asserted-by":"crossref","first-page":"8564","DOI":"10.1021\/cr500131f","article-title":"Biodegradable polymer nanogels for drug\/nucleic acid delivery","volume":"115","author":"Li Y","year":"2015","journal-title":"Chem Rev"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/1759720X10383076","article-title":"Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations","volume":"2","author":"Henrotin Y","year":"2010","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1097\/01.COC.0000072505.67810.B1","article-title":"Does the addition of glutamine to total parenteral nutrition have beneficial effect on the healing of colon anastomosis and bacterial translocation after preoperative radiotherapy?","volume":"26","author":"El-Malt M","year":"2003","journal-title":"Am J Clin Oncol"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000100111","article-title":"Effects of two conventional preoperative radiation schedules on anastomotic healing in the rat colon","volume":"39","author":"Bedirli A","year":"2007","journal-title":"Eur Surg Res"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.clnu.2006.01.028","article-title":"Effects of soluble fiber on matrix metalloproteinase-2 activity and healing of colon anastomosis in rats given radiotherapy","volume":"25","author":"Kerem M","year":"2006","journal-title":"Clin Nutr"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1590\/s0102-865020170040000007","article-title":"Development of a new model of actinic enteritis in rats using a cobalt-60 open source and a protection device as a collimator","volume":"32","author":"Nunes VRT","year":"2017","journal-title":"Acta Cir Bras"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3332\/ecancer.2017.784","article-title":"History of the development of radiotherapy in Latin America","volume":"11","author":"Pinillos L","year":"2017","journal-title":"Ecancermedicalscience"},{"issue":"5-6","key":"ref16","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.canrad.2013.06.041","article-title":"Radioth\u00e9rapie pr\u00e9op\u00e9ratoire des cancers du rectum: volumes cibles","volume":"17","author":"Huertas A","year":"2013","journal-title":"Cancer Radiother"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3346\/jkms.2000.15.6.682","article-title":"A rat model for radiation-induced proctitis","volume":"15","author":"Kan S","year":"2000","journal-title":"J Korean Med Sci"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1111\/j.1572-0241.2000.02013.x","article-title":"Mucosal cytokine production in radiation-induced proctosigmoiditis compared with inflammatory bowel disease","volume":"95","author":"Indaram AV","year":"2000","journal-title":"Am J Gastroenterol"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1002\/1097-0142(19881101)62:9<1962::AID-CNCR2820620916>3.0.CO;2-T","article-title":"Radiation proctitis in the rat. Sequential changes and effects of anti-inflammatory agents","volume":"62","author":"Northway MG","year":"1988","journal-title":"Cancer"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4292\/wjgpt.v6.i1.1","article-title":"Prevention of pelvic radiation disease","volume":"6","author":"Fuccio L","year":"2015","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"ref21","first-page":"CD009839","article-title":"Mesalamine (5-ASA) for the prevention of recurrent diverticulitis","volume":"10","author":"Carter F","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2165\/00003495-199856010-00008","article-title":"Balsalazide","volume":"56","author":"Prakash A","year":"1998","journal-title":"Drugs"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0936-6555(05)80689-2","article-title":"A randomized trial to assess the efficacy of 5-aminosalicylic acid for the prevention of radiation enteritis","volume":"5","author":"Baughan CA","year":"1993","journal-title":"Clin Oncol R Coll Radiol"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v25.i3.10","article-title":"Mucoadhesion and the gastrointestinal tract","volume":"25","author":"Varum FJ","year":"2008","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"issue":"1&#8211;2","key":"ref25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ijpharm.2014.04.040","article-title":"Preparation and evaluation of colon adhesive pellets of 5-aminosalicylic acid","volume":"468","author":"Xu M","year":"2014","journal-title":"Int J Pharm"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.acuro.2013.01.008","article-title":"Experiencia a largo plazo con condroit\u00edn sulfato s\u00f3dico em pacientes con s\u00edndrome de vejiga dolorosa","volume":"37","author":"Tornero JI","year":"2013","journal-title":"Actas Urol Esp"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s00192-010-1357-0","article-title":"Prophylactic vesical instillations with 0.2% chondroitin sulfate may reduce symptoms of acute radiation cystitis in patients undergoing radiotherapy for gynecological malignancies","volume":"22","author":"Hazewinkel MH","year":"2011","journal-title":"Int Urogynecol J"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.clgc.2016.01.016","article-title":"Bladder instillation therapy with hyaluronic acid and chondroitin sulfate improves symptoms of postradiation cystitis: prospective pilot study","volume":"14","author":"Gacci M","year":"2016","journal-title":"Clin Genitourin Cancer"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1055\/s-2008-1027150","article-title":"Medical prevention and treatment of acute and chronic radiation induced enteritis--is there any proven therapy? A short review","volume":"46","author":"Zimmerer T","year":"2008","journal-title":"Z Gastroenterol"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1124\/jpet.107.129122","article-title":"Reduction of peroxisome proliferation-activated receptor gamma expression by gamma-irradiation as a mechanism contributing to inflammatory response in rat colon: modulation by the 5-aminosalicylic acid agonist","volume":"324","author":"Linard C","year":"2008","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T06:55:29Z","timestamp":1633848929000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502021000800205&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":30,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021]]}},"alternative-id":["S0102-86502021000800205"],"URL":"https:\/\/doi.org\/10.1590\/acb360805","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"type":"electronic","value":"1678-2674"},{"type":"print","value":"0102-8650"}],"subject":[],"published":{"date-parts":[[2021]]},"article-number":"e360805"}}