{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:07:19Z","timestamp":1791518839089,"version":"4.3.4"},"reference-count":36,"publisher":"FapUNIFESP (SciELO)","issue":"12","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"DOI":"10.1590\/acb361201","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T17:39:51Z","timestamp":1639762791000},"source":"Crossref","is-referenced-by-count":2,"title":["Use of hyaluronic acid associated with triamcinolone acetonide or ozone gas in the treatment of induced osteoarthritis in rabbits"],"prefix":"10.1590","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7639-5032","authenticated-orcid":false,"given":"Giovanna Cristina","family":"Brombini","sequence":"first","affiliation":[{"name":"Universidade Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9211-4093","authenticated-orcid":false,"given":"Sheila Canevese","family":"Rahal","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7687-3161","authenticated-orcid":false,"given":"Alexandre Todorovic","family":"Fabro","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1175-4532","authenticated-orcid":false,"given":"Ivan Felismino Charas dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-4230","authenticated-orcid":false,"given":"Miriam Harumi","family":"Tsunemi","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0765-3974","authenticated-orcid":false,"given":"Jean Guilherme Fernandes","family":"Joaquim","sequence":"additional","affiliation":[{"name":"Bioethicus Institute,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-0142","authenticated-orcid":false,"given":"Danuta Pulz","family":"Doiche","sequence":"additional","affiliation":[{"name":"Private Practice,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2852-6288","authenticated-orcid":false,"given":"Jeana Pereira da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2238-5584","authenticated-orcid":false,"given":"Maria Jaqueline","family":"Mamprim","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2021]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.5312\/wjo.v5.i3.351","article-title":"Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis","volume":"5","author":"Ayhan E","year":"2014","journal-title":"World J Orthop"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40634-016-0060-6","article-title":"Basic science of osteoarthritis","volume":"3","author":"Cucchiarini M","year":"2016","journal-title":"J Exp Orthop"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.mcna.2019.10.007","article-title":"Osteoarthritis: pathology, diagnosis, and treatment options","volume":"104","author":"Abramoff B","year":"2020","journal-title":"Med Clin North Am"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00296-010-1660-6","article-title":"The role of intra-articular hyaluronan (Sinovial) in the treatment of osteoarthritis","volume":"31","author":"Gigante A","year":"2011","journal-title":"Rheumatol Int"},{"issue":"3","key":"ref5","first-page":"232","article-title":"Could ozone be used as a feasible future treatment in osteoarthritis of the knee?","volume":"13","author":"Fernandez-Cuadros ME","year":"2016","journal-title":"Divers Equal Health Care"},{"key":"ref6","series-title":"Knee osteoarthritis","author":"Hsu H","year":"2021"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4172\/2167-7921.1000242","article-title":"Intra-articular Injections for management of knee osteoarthritis","volume":"6","author":"Golding D","year":"2017","journal-title":"J Arthritis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bone.2016.01.019","article-title":"Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges","volume":"85","author":"Rahmati M","year":"2016","journal-title":"Bone"},{"issue":"2 Suppl 1","key":"ref9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1053\/sarh.2000.0246","article-title":"Sodium hyaluronate therapy in osteoarthritis: arguments for a potential beneficial structural effect","volume":"30","author":"Dougados M","year":"2000","journal-title":"Semin Arthritis Rheum"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40169-017-0180-3","article-title":"Recent advances in hyaluronic acid based therapy for osteoarthritis","volume":"7","author":"Bowman S","year":"2018","journal-title":"Clin Transl Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fvets.2019.00192","article-title":"Hyaluronic acid: molecular mechanisms and therapeutic trajectory","volume":"6","author":"Gupta RC","year":"2019","journal-title":"Front Vet Sci"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1620\/tjem.199.127","article-title":"Comparative effect of intra-articular administration of hyaluronan and\/or cortisone with evaluation of malondialdehyde on degenerative osteoarthritis of the rabbit\u2019s knee","volume":"199","author":"Karakurum G","year":"2003","journal-title":"Tohoku J Exp Med"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s00296-005-0584-z","article-title":"The safety and efficacy of intraarticular hyaluronan with\/without corticosteroid in knee osteoarthritis: 1-year, single-blind, randomized study","volume":"26","author":"Ozturk C","year":"2006","journal-title":"Rheumatol Int"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/1947603517703732","article-title":"Intraarticular injection of a cross-linked sodium hyaluronate combined with triamcinolone hexacetonide (Cingal) to provide symptomatic relief of osteoarthritis of the knee: a randomized, double-blind, placebo-controlled multicenter clinical trial","volume":"9","author":"Hangody L","year":"2018","journal-title":"Cartilage"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1007\/s00167-018-5071-7","article-title":"Combined intra-articular injection of corticosteroid and hyaluronic acid reduces pain compared to hyaluronic acid alone in the treatment of knee osteoarthritis","volume":"27","author":"Smith C","year":"2019","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.sjbs.2016.02.002","article-title":"Medical ozone therapy as a potential treatment modality for regeneration of damaged articular cartilage in osteoarthritis","volume":"25","author":"Manoto SL","year":"2018","journal-title":"Saudi J Biol Sci"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/2045-9912.241075","article-title":"Clinical utility of ozone therapy for musculoskeletal disorders","volume":"8","author":"Seyam O","year":"2018","journal-title":"Med Gas Res"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1063-4584(05)80318-8","article-title":"Characterization of a model of osteoarthritis in the rabbit knee","volume":"4","author":"Yoshioka M","year":"1996","journal-title":"Osteoarthritis Cartilage"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2342-10-3","article-title":"Radiographic assessment of the femorotibial joint of the CCLT rabbit experimental model of osteoarthritis","volume":"10","author":"Boulocher CB","year":"2010","journal-title":"BMC Med Imaging"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10735-012-9457-4","article-title":"Preliminary histopathological study of intra-articular injection of a novel highly cross-linked hyaluronic acid in a rabbit model of knee osteoarthritis","volume":"44","author":"Iannitti T","year":"2013","journal-title":"J Mol Histol"},{"key":"ref21","first-page":"46","article-title":"Articular cartilage matrix and structure: a minireview","volume":"27","author":"Kuettner KE","year":"1991","journal-title":"J Rheumatol Suppl"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1172\/JCI4853","article-title":"Evidence for altered synthesis of type II collagen in patients with osteoarthritis","volume":"102","author":"Nelson F","year":"1998","journal-title":"J Clin Invest"},{"issue":"3","key":"ref23","first-page":"273","article-title":"Macroscopic analyses of the effects of hyaluronates and corticosteroids on induced osteoarthritis in rabbits\u2019 knees","volume":"45","author":"Albano MB","year":"2015","journal-title":"Rev Bras Ortop"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ejpb.2015.09.005","article-title":"Efficacy study of two novel hyaluronic acid-based formulations for viscosupplementation therapy in an early osteoarthrosic rabbit model","volume":"96","author":"Kaderli S","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","DOI":"10.1177\/2325967115581163","article-title":"The effect of intra-articular corticosteroids on articular cartilage: a systematic review","volume":"3","author":"Wernecke C","year":"2015","journal-title":"Orthop J Sports Med"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"638","DOI":"10.5435\/00124635-200910000-00006","article-title":"The efficacy and duration of intra-articular corticosteroid injection for knee osteoarthritis: a systematic review of level I studies","volume":"17","author":"Hepper CT","year":"2009","journal-title":"J Am Acad Orthop Surg"},{"issue":"10","key":"ref27","first-page":"576","article-title":"Ozone therapy in knee osteoarthritis: a systematic review","volume":"31","author":"Costa T","year":"2018","journal-title":"Acta Med Port"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.arthro.2019.09.036","article-title":"Editorial Commentary: Is medical ozone therapy beneficial in the treatment of knee osteoarthritis?","volume":"36","author":"Manoto SL","year":"2020","journal-title":"Arthroscopy"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179185","article-title":"Comparison between intra-articular ozone and placebo in the treatment of knee osteoarthritis: a randomized, double-blinded, placebo-controlled study","volume":"12","author":"Lopes de Jesus CC","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"ref30","first-page":"33","article-title":"The temporal effect of intra-articular ozone injections on pain in knee osteoarthritis","volume":"132","author":"Oliviero A","year":"2019","journal-title":"Br Med Bull"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00167-016-4110-5","article-title":"Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options","volume":"25","author":"Duymus TM","year":"2017","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2147\/JPR.S142755","article-title":"Intra-articular ozone or hyaluronic acid injection: which one is superior in patients with knee osteoarthritis? A 6-month randomized clinical trial","volume":"11","author":"Raeissadat SA","year":"2018","journal-title":"J Pain Res"},{"key":"ref33","first-page":"59","article-title":"Is medical ozone safe when injected intra-articularly? A comparative histological study in rat","volume":"7","author":"Iliakis E","year":"2008","journal-title":"Int. J. Ozone Ther"},{"issue":"2","key":"ref34","first-page":"621","article-title":"Comparison between intrarticular injection of hyaluronic acid, oxygen ozone, and the combination of both in the treatment of knee osteoarthrosis","volume":"30","author":"Giombini A","year":"2016","journal-title":"J Biol Regul Homeost Agents"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ctim.2018.11.023","article-title":"Intra-articular ozone therapy efficiently attenuates pain in knee osteoarthritic subjects: a systematic review and meta-analysis","volume":"42","author":"Noori-Zadeh A","year":"2019","journal-title":"Complement Ther Med"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.arthro.2019.05.043","article-title":"Oxygen-ozone therapy for the treatment of knee osteoarthritis: a systematic review of randomized controlled trials","volume":"36","author":"Sconza C","year":"2020","journal-title":"Arthroscopy"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/acb\/v36n12\/1678-2674-acb-36-12-e361201.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T17:40:33Z","timestamp":1639762833000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502021001200200&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":36,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021]]}},"alternative-id":["S0102-86502021001200200"],"URL":"https:\/\/doi.org\/10.1590\/acb361201","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"article-number":"e361201"}}