{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:16:23Z","timestamp":1753888583850,"version":"3.41.2"},"reference-count":44,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"DOI":"10.1590\/acb370403","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T12:18:27Z","timestamp":1657887507000},"source":"Crossref","is-referenced-by-count":3,"title":["The effects of valproic acid on skin healing: experimental study in rats"],"prefix":"10.1590","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2129-3848","authenticated-orcid":false,"given":"Rachel","family":"Biondo-Sim\u00f5es","sequence":"first","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-8142","authenticated-orcid":false,"given":"Maria de Lourdes Pessole","family":"Biondo-Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7871-4463","authenticated-orcid":false,"given":"S\u00e9rgio Ossamu","family":"Ioshii","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3598-6370","authenticated-orcid":false,"given":"Rog\u00e9rio Ribeiro","family":"Robes","sequence":"additional","affiliation":[{"name":"Pontificia Universidade Cat\u00f3lica do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4937-1801","authenticated-orcid":false,"given":"Moacir de Oliveira","family":"Dall\u2019Antonia","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2022]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ctrv.2007.11.003","article-title":"Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors","volume":"34","author":"Ala MJ","year":"2008","journal-title":"Cancer Treat Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejphar.2018.07.057","article-title":"Valproic acid as an adjunctive therapeutic agent for the treatment of breast cancer","volume":"835","author":"Heers H","year":"2018","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.psym.2014.02.007","article-title":"Valproic acid-induced thrombocytopenia may cause wound nonhealing in individuals with schizophrenia","volume":"56","author":"Tseng Y-T","year":"2015","journal-title":"Psychosomatics"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1124\/mol.65.3.520","article-title":"Valproic acid inhibits angiogenesis in vitro and in vivo","volume":"65","author":"Michaelis M","year":"2004","journal-title":"Mol Pharmacol"},{"issue":"11","key":"ref5","article-title":"Valproic acid induces cutaneous wound healing in vivo and enhances keratinocyte motility","volume":"7","author":"Lee S","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/MBC.0000000000000626","article-title":"Valproic acid modulates platelet and coagulation function ex vivo","volume":"28","author":"Bambakidis T","year":"2017","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0074-7696(07)57004-X","article-title":"Fibroblast differentiation in wound healing and fibrosis","volume":"257","author":"Darby IA","year":"2007","journal-title":"Int Rev Cytol"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jss.2019.09.036","article-title":"Sodium valproate improves skin flap survival via gamma-aminobutyric acid and histone deacetylase inhibitory system","volume":"246","author":"Ala M","year":"2020","journal-title":"J Surg Res"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.canlet.2009.02.045","article-title":"Differential effects of valproic acid on growth, proliferation and metastasis in HTB5 and HTB9 bladder cancer cell lines","volume":"281","author":"Byun SS","year":"2009","journal-title":"Cancer Lett"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2176\/nmc.52.186","article-title":"Valproic acid inhibits angiogenesis in vitro and glioma angiogenesis in vivo in the brain","volume":"52","author":"Osuka S","year":"2012","journal-title":"Neurol Med Chir"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.3390\/ijms18071414","article-title":"Histone deacetylase inhibitors as anticancer drugs","volume":"18","author":"Eckschlager T","year":"2017","journal-title":"Int J Mol Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.critrevonc.2017.01.020","article-title":"Epigenetic control of gene expression: Potential implications for cancer treatment","volume":"111","author":"Perri F","year":"2017","journal-title":"Crit Rev Oncol Hematol"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3892\/or.2013.2913","article-title":"Epigenetic regulation and cancer (review)","volume":"31","author":"Chen QW","year":"2014","journal-title":"Oncol Rep"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/apm.12906","article-title":"Epigenetic therapy in hematological cancers","volume":"127","author":"Dimopoulos K","year":"2019","journal-title":"APMIS"},{"issue":"3","key":"ref15","first-page":"1431","article-title":"Predicting resistance to endocrine therapy in breast cancer: it\u2019s time for epigenetic biomarkers (Review)","volume":"41","author":"Fontes-Sousa M","year":"2019","journal-title":"Oncol Rep"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.breast.2018.12.001","article-title":"The role of histone deacetylase inhibitors in metastatic breast cancer","volume":"43","author":"Zucchetti B","year":"2019","journal-title":"Breast"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3390\/ijms20020297","article-title":"Epigenetic mechanisms influencing epithelial to mesenchymal transition in bladder cancer","volume":"20","author":"Monteiro-Reis S","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13148-017-0398-3","article-title":"Histone code and long non-coding RNAs (lncRNAs) aberrations in lung cancer: implications in the therapy response","volume":"9","author":"Herrera-Solorio AM","year":"2017","journal-title":"Clin Epigenetics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.semcancer.2017.09.005","article-title":"Lung cancer epigenetics: from knowledge to applications","volume":"51","author":"Duruisseaux M","year":"2018","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12902-019-0356-5","article-title":"Genetic and epigenetic characteristics in ovarian tissues from polycystic ovary syndrome patients with irregular menstruation resemble those of ovarian cancer","volume":"19","author":"Jiao J","year":"2019","journal-title":"BMC Endocr Disord"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.3892\/or.2017.5972","article-title":"DNA methylation and histone modifications as epigenetic regulation in prostate cancer (Review)","volume":"38","author":"Nowacka-Zawisza M","year":"2017","journal-title":"Oncol Rep"},{"issue":"4","key":"ref22","first-page":"303","article-title":"DNA methylation patterns as molecular biomarkers: an overview in colorectal cancer","volume":"22","author":"Gonz\u00e1lez-Flores E","year":"2018","journal-title":"Eur J Anat"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.3390\/ijms19123978","article-title":"The epigenetic regulation of HCC metastasis","volume":"19","author":"Han T-S","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/phar.1408","article-title":"Epigenetics and oncology","volume":"34","author":"Mummanemi P","year":"2014","journal-title":"Pharmacotherapy"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1528-1167.2007.01429.x","article-title":"Valproate-induced thrombocytopenia: a prospective monotherapy study","volume":"49","author":"Nasreddine W","year":"2008","journal-title":"Epilepsia"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/JCP.0b013e3181db2684","article-title":"Hematological effects of valproate in psychiatric patients: what are the risk factors?","volume":"30","author":"Vasudev K","year":"2010","journal-title":"J Clin Psychopharmacol"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.surg.2014.09.031","article-title":"Combined intraoperative administration of a histone deacetylase inhibitor and a neurokinin-1 receptor antagonist synergistically reduces intra-abdominal adhesion formation in a rat model","volume":"157","author":"Cassidy MR","year":"2015","journal-title":"Surgery"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jpba.2018.09.010","article-title":"Pharmacokinetics and tissue distribution of N-(2-hydroxyphenyl)-2-propylpentanamide in Wistar Rats and its binding properties to human serum albumin","volume":"162","author":"Correa-Basurtoa AM","year":"2019","journal-title":"J Pharm Biomed Anal"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1590\/S1676-24442003000200009","article-title":"Influ\u00eancia da cisplatina administrada no pr\u00e9 e no p\u00f3s-operat\u00f3rio sobre a cicatriza\u00e7\u00e3o de anastomoses col\u00f4nicas em ratos","volume":"39","author":"Vizzotto Junior AO","year":"2003","journal-title":"J Bras Patol Med Lab"},{"issue":"Suppl. 3","key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0074-02761991000700002","article-title":"The use of the picrosirius-polarization method for the study of the biopathology of collagen","volume":"86","author":"Montes GS","year":"1991","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref31","series-title":"Fribrosis: methods in molecular biology","first-page":"395","volume-title":"Method for picrosirius red-polarization detection of collagen fibers in tissue sections","volume":"1627","author":"Ritti\u00e9 L","year":"2017"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures","volume":"29","author":"Hsu SM","year":"1981","journal-title":"J Histochem Cytochem"},{"issue":"265","key":"ref33","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: mechanisms, signaling, and translation","volume":"6","author":"Eming SA","year":"2014","journal-title":"Sci Transl Med"},{"issue":"8","key":"ref34","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/exd.14325","article-title":"Epigenetic regulation of cellular functions in wound healing","volume":"30","author":"Pastar I","year":"2021","journal-title":"Exp Dermatol"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/wrr.12838","article-title":"A review of epigenetic regulation in wound healing: Implications for the future of wound care","volume":"28","author":"Lewis CJ","year":"2020","journal-title":"Wound Repair Regen"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nrm3382","article-title":"New insights into necleosome and chromatin structure: an ordered state or a disordered affair?","volume":"13","author":"Luger K","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.15252\/embr.201540945","article-title":"The interplay of histone modifications - writers that read","volume":"16","author":"Zhang T","year":"2015","journal-title":"EMBO Rep"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/wound.2014.0561","article-title":"Extracellular matrix and dermal fibroblast function in the healing wound","volume":"5","author":"Tracy LE","year":"2016","journal-title":"Adv Wound Care"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.retram.2016.09.003","article-title":"The role of myofibroblasts in wound healing","volume":"64","author":"Hinz B","year":"2016","journal-title":"Curr Res Transl Med"},{"issue":"25","key":"ref40","doi-asserted-by":"crossref","first-page":"22491","DOI":"10.1074\/jbc.M100206200","article-title":"Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts","volume":"276","author":"Brinkmann H","year":"2001","journal-title":"J Biol Chem"},{"issue":"16","key":"ref41","doi-asserted-by":"crossref","first-page":"11004","DOI":"10.1074\/jbc.M112.441816","article-title":"A nitric oxide-dependent cross-talk between class I and III histone deacetylases accelerates skin repair","volume":"288","author":"Spallotta F","year":"2013","journal-title":"J Biol Chem"},{"issue":"9","key":"ref42","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/01.RES.0000037983.07158.B1","article-title":"Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis","volume":"91","author":"R\u00f6ssig L","year":"2002","journal-title":"Cir Res"},{"issue":"6736","key":"ref43","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/21218","article-title":"Regulation of endothelium-derived nitric oxide production by the protein kinase Akt","volume":"399","author":"Fulton D","year":"1999","journal-title":"Nature"},{"issue":"12","key":"ref44","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1172\/JCI119868","article-title":"Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells","volume":"100","author":"Papapetropoulos A","year":"1997","journal-title":"J Clin Invest"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502022000400205&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T16:29:22Z","timestamp":1659544162000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502022000400205&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":44,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022]]}},"alternative-id":["S0102-86502022000400205"],"URL":"https:\/\/doi.org\/10.1590\/acb370403","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"type":"electronic","value":"1678-2674"},{"type":"print","value":"0102-8650"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e370403"}}