{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:49:59Z","timestamp":1779889799311,"version":"3.53.1"},"reference-count":41,"publisher":"FapUNIFESP (SciELO)","issue":"5","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"DOI":"10.1590\/acb370505","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T13:21:10Z","timestamp":1660310470000},"source":"Crossref","is-referenced-by-count":9,"title":["The ethanol extract of Periplaneta Americana L. improves ulcerative colitis induced by a combination of chronic stress and TNBS in rats"],"prefix":"10.1590","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8614-7465","authenticated-orcid":false,"given":"Jing-na","family":"Zhang","sequence":"first","affiliation":[{"name":"Dali University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0862-5913","authenticated-orcid":false,"given":"Min-zhe","family":"Sun","sequence":"additional","affiliation":[{"name":"Dali University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-4985","authenticated-orcid":false,"given":"Heng","family":"Liu","sequence":"additional","affiliation":[{"name":"Dali University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0350-2906","authenticated-orcid":false,"given":"Han-chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dali University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3427-2197","authenticated-orcid":false,"given":"Huai","family":"Xiao","sequence":"additional","affiliation":[{"name":"Dali University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8607-8500","authenticated-orcid":false,"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Dali University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2691-5079","authenticated-orcid":false,"given":"Chenggui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dali University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0000-8136","authenticated-orcid":false,"given":"Hai-rong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Dali University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2022]]},"reference":[{"issue":"9853","key":"ref1","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Ord\u00e1s I","year":"2012","journal-title":"Lancet"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.immuni.2019.06.008","article-title":"Temporally distinct functions of the cytokines IL-12 and IL-23 drive chronic colon inflammation in response to intestinal barrier impairment","volume":"51","author":"Eftychi C","year":"2019","journal-title":"Immunity"},{"issue":"13","key":"ref3","article-title":"Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response","volume":"115","author":"Gao X","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1053\/j.gastro.2009.04.032","article-title":"Evidence for the role of the brain-gut axis in inflammatory bowel disease: depression as cause and effect?","volume":"136","author":"Tache Y","year":"2009","journal-title":"Gastroenterology"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"892","DOI":"10.2174\/1570159X14666160404124127","article-title":"Mechanisms by which stress affects the experimental and clinical inflammatory bowel disease (IBD): role of brain-gut axis","volume":"14","author":"Brzozowski B","year":"2016","journal-title":"Curr Neuropharmacol"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/19490976.2016.1273999","article-title":"Structural and functional alterations in the colonic microbiome of the rat in a model of stress induced irritable bowel syndrome","volume":"8","author":"Fourie NH","year":"2017","journal-title":"Gut Microbes"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.biopsych.2016.12.031","article-title":"Targeting the microbiota-gut-brain axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice","volume":"82","author":"Burokas A","year":"2017","journal-title":"Biol Psychiatry"},{"issue":"7","key":"ref8","first-page":"1507","article-title":"Research status of Periplaneta americana with analyses and prospects of key issues","volume":"43","author":"Li QJ","year":"2018","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.12659\/MSM.912980","article-title":"To explore the protective mechanism of PTEN-induced kinase 1 (PINK1)\/parkin mitophagy-mediated extract of Periplaneta Americana on lipopolysaccharide-induced cardiomyocyte injury","volume":"25","author":"Li J","year":"2019","journal-title":"Med Sci Monit"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/abbs\/gmy024","article-title":"Anti-fibrotic role and mechanism of Periplaneta americana extracts in CCl4-induced hepatic fibrosis in rats","volume":"50","author":"Li D","year":"2018","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"1-2","key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000488535","article-title":"Periplaneta Americana extract may attenuate renal fibrosis through inhibiting janus tyrosine kinase 2\/signal Transducer and activator of transcription 3 pathway","volume":"102","author":"Liu J","year":"2018","journal-title":"Pharmacology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1186\/s12906-017-1917-7","article-title":"Evidence based anti-osteoporosis effects of Periplaneta americana L on osteoblasts, osteoclasts, vascular endothelial cells and bone marrow derived mesenchymal stem cells","volume":"17","author":"Huang YF","year":"2017","journal-title":"BMC Complement Altern Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cbi.2017.06.007","article-title":"Mechanistic evaluation of gastroprotective effects of Kangfuxin on ethanol-induced gastric ulcer in mice","volume":"273","author":"Shen Y","year":"2017","journal-title":"Chem Biol Interact"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"108858","DOI":"10.1016\/j.biopha.2019.108858","article-title":"Periplaneta Americana L. as a novel therapeutics accelerates wound repair and regeneration","volume":"114","author":"Li LJ","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13020-019-0259-4","article-title":"The crude ethanol extract of Periplaneta americana L. stimulates wound healing in vitro & in vivo","volume":"14","author":"Li LJ","year":"2019","journal-title":"Chin Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"118707","DOI":"10.1016\/j.ijpharm.2019.118707","article-title":"A feasible biocompatible hydrogel film embedding Periplaneta americana extract for acute wound healing","volume":"571","author":"Chen Z","year":"2019","journal-title":"Int J Pharm"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3390\/molecules23010101","article-title":"Bioactivity-guided screening of wound-healing active constituents from american cockroach (Periplaneta americana)","volume":"23","author":"Zhu JJ","year":"2018","journal-title":"Molecules"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5821706","article-title":"Periplaneta americana extracts promote skin wound healing via nuclear factor kappa B canonical pathway and extracellular signal-regulated kinase signaling","volume":"2017","author":"Song Q","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.3109\/13880209.2016.1170862","article-title":"Protective effect of Periplaneta americana extract in ulcerative colitis rats induced by dinitrochlorobenzene and acetic acid","volume":"54","author":"Li N","year":"2016","journal-title":"Pharm Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3389\/fphar.2018.00944","article-title":"Periplaneta americana ameliorates dextran sulfate sodium-induced ulcerative colitis in rats by Keap1\/Nrf-2 activation, intestinal barrier function, and gut microbiota regulation","volume":"9","author":"Ma X","year":"2018","journal-title":"Front Pharmacol"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.7150\/thno.39241","article-title":"A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor \u03b1-dependent transcriptional activation and breast carcinogenesis","volume":"10","author":"Peng B-l","year":"2020","journal-title":"Theranostics"},{"issue":"10","key":"ref22","first-page":"1796","article-title":"Evaluation of depression models in rats of different age groups","volume":"31","author":"Dong H","year":"2011","journal-title":"Chin J Gerontol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/mp.2017.76","article-title":"Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs","volume":"23","author":"Li MX","year":"2018","journal-title":"Mol Psychiatry"},{"issue":"10","key":"ref24","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.intimp.2011.05.024","article-title":"Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis","volume":"11","author":"Wang YH","year":"2011","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1172\/JCI42917","article-title":"PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice","volume":"121","author":"Qiu W","year":"2011","journal-title":"J Clin Invest"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S2468-1253(18)30306-6","article-title":"A composite disease activity index for early drug development in ulcerative colitis: development and validation of the UC-100 score","volume":"4","author":"Jairath V","year":"2019","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/aps.2017.185","article-title":"Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis via suppressing neutrophils and macrophages","volume":"39","author":"Yan YX","year":"2018","journal-title":"Acta Pharmacol Sin"},{"issue":"9","key":"ref28","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1080\/003655298750027001","article-title":"An orally administered growth factor extract derived from bovine whey suppresses breath ethane in colitic rats","volume":"33","author":"Porter SN","year":"1998","journal-title":"Scand J Gastroenterol"},{"key":"ref29","article-title":"Influence of rosiglitazone on the expression of PPAR gamma, NF-kappaB, and TNF-alpha in rat model of ulcerative colitis","volume":"2012","author":"Mao JW","year":"2012","journal-title":"Gastroenterol Res Pract"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1136\/gut.39.3.407","article-title":"Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis","volume":"39","author":"Millar AD","year":"1996","journal-title":"Gut"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s42003-022-03024-5","article-title":"Vespakinin-M, a natural peptide from Vespa magnifica, promotes functional recovery in stroke mice","volume":"5","author":"Zhao H","year":"2022","journal-title":"Commun Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1056\/NEJMra0804647","article-title":"Inflammatory bowel disease","volume":"361","author":"Abraham C","year":"2009","journal-title":"N Engl J Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10208","article-title":"Intestinal homeostasis and its breakdown in inflammatory bowel disease","volume":"474","author":"Maloy KJ","year":"2011","journal-title":"Nature"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1146\/annurev-immunol-030409-101225","article-title":"Inflammatory bowel disease","volume":"28","author":"Kaser A","year":"2010","journal-title":"Annu Rev Immunol"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1002\/mnfr.200700515","article-title":"6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages","volume":"52","author":"Pan MH","year":"2008","journal-title":"Mol Nutr Food Res"},{"key":"ref36","article-title":"Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) expression in ulcerative colitis and Crohn\u2019s disease","volume":"4","author":"Fu S","year":"1996","journal-title":"Gastroenterology"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.intimp.2013.09.022","article-title":"Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-kappa B signal transduction pathways in rats with ulcerative colitis","volume":"17","author":"Sakthivel KM","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"ref38","article-title":"Periplanetols A-F, phenolic compounds from Periplaneta americana with potent COX-2 inhibitory activity","volume":"143","author":"Bai HF","year":"2020","journal-title":"Fitoterapia"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1056\/NEJMoa013136","article-title":"Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-sided ulcerative colitis or proctitis","volume":"349","author":"Sinha A","year":"2003","journal-title":"N Engl J Med"},{"issue":"9853","key":"ref40","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Ord\u00e1s I","year":"2012","journal-title":"Lancet"},{"issue":"6","key":"ref41","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1053\/j.gastro.2019.09.002","article-title":"Suppressive and gut-reparative functions of human Type 1 T regulatory cells","volume":"157","author":"Cook L","year":"2019","journal-title":"Gastroenterology"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502022000500204&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T13:22:12Z","timestamp":1660310532000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502022000500204&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022]]}},"alternative-id":["S0102-86502022000500204"],"URL":"https:\/\/doi.org\/10.1590\/acb370505","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e370505"}}