{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T01:45:55Z","timestamp":1779155155667,"version":"3.51.4"},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","issue":"7","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"DOI":"10.1590\/acb370703","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T12:11:43Z","timestamp":1668168703000},"source":"Crossref","is-referenced-by-count":7,"title":["Effects of dexmedetomidine on hemodynamic, oxygenation, microcirculation, and inflammatory markers in a porcine model of sepsis"],"prefix":"10.1590","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-0104","authenticated-orcid":false,"given":"Paulo","family":"Carnicelli","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7411-3898","authenticated-orcid":false,"given":"Denise Aya","family":"Otsuki","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-3717","authenticated-orcid":false,"given":"Adalberto","family":"Monteiro Filho","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Ufape,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1801-5633","authenticated-orcid":false,"given":"Marcia Aparecida Portela","family":"Kahvegian","sequence":"additional","affiliation":[{"name":"All Care Vet,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2200-4355","authenticated-orcid":false,"given":"Keila Kazue","family":"Ida","sequence":"additional","affiliation":[{"name":"Texas A&M University,  United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3919-1743","authenticated-orcid":false,"given":"Jos\u00e9 Otavio Costa","family":"Auler-Jr","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9092-4642","authenticated-orcid":false,"given":"Jean-Jacques","family":"Rouby","sequence":"additional","affiliation":[{"name":"Medicine Sorbonne University,  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8452-2038","authenticated-orcid":false,"given":"Denise Tabacchi","family":"Fantoni","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2022]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/ACO.0000000000000957","article-title":"Septic shock: a microcirculation disease","volume":"34","author":"De Backer D","year":"2021","journal-title":"Curr Opin Anesthesiol"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1097\/01.CCM.0000138558.16257.3F","article-title":"Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock","volume":"32","author":"Sakr Y","year":"2004","journal-title":"Crit Care Med"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2146\/ajhp050508","article-title":"Sedation and analgesia in the intensive care unit: evaluating the role of dexmedetomidine","volume":"64","author":"Szumita PM","year":"2007","journal-title":"Am J Health Syst Pharm"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1097\/ALN.0b013e31825681cb","article-title":"Effect of perioperative systemic alpha2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials","volume":"116","author":"Blaudszun G","year":"2012","journal-title":"Anesthesiology"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1097\/01.CCM.0000128579.84228.2A","article-title":"Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats","volume":"32","author":"Taniguchi T","year":"2004","journal-title":"Crit Care Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s12871-018-0625-2","article-title":"Immunomodulatory effects of intraoperative dexmedetomidine on T helper 1, T helper 2, T helper 17 and regulatory T cells cytokine levels and their balance: a prospective, randomised, double-blind, dose-response clinical study","volume":"18","author":"Lee JM","year":"2018","journal-title":"BMC Anesthesiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/00000542-200008000-00016","article-title":"The effects of increasing plasma concentrations of dexmedetomidine in humans","volume":"93","author":"Ebert TJ","year":"2000","journal-title":"Anesthesiology"},{"issue":"10054","key":"ref8","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/S0140-6736(16)30580-3","article-title":"Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial","volume":"388","author":"Su X","year":"2016","journal-title":"Lancet"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1164\/rccm.201710-1995OC","article-title":"Low-dose nocturnal dexmedetomidine prevents ICU delirium. A randomized, placebo-controlled trial","volume":"197","author":"Skrobik Y","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1590\/S0100-879X2005000600009","article-title":"Short-lasting systemic and regional benefits of early crystalloid infusion after intravenous inoculation of dogs with live Escherichia coli","volume":"38","author":"Garrido AG","year":"2005","journal-title":"Braz J Med Biol Res"},{"issue":"6","key":"ref11","first-page":"1205","article-title":"Fluid replacement with hypertonic or isotonic solutions guided by mixed venous oxygen saturation in experimental hypodynamic sepsis","volume":"67","author":"Rahal L","year":"2009","journal-title":"J Trauma"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/01.CCM.0000298158.12101.41","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock","volume":"36","author":"Dellinger RP","year":"2008","journal-title":"Crit Care Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1152\/ajplegacy.1968.215.3.704","article-title":"Ventricular volumes and body weight in mammals","volume":"215","author":"Holt JP","year":"1968","journal-title":"Am J Physiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2018.05.001","article-title":"Dexmedetomidine restores septic renal function via promoting inflammation resolution in a rat sepsis model","volume":"204","author":"Qiu R","year":"2018","journal-title":"Life Sci"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/ki.2015.306","article-title":"Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery","volume":"89","author":"Cho JS","year":"2016","journal-title":"Kidney Int"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12871-018-0472-1","article-title":"Dexmedetomidine prevents acute kidney injury after adult cardiac surgery: a meta-analysis of randomized controlled trials","volume":"18","author":"Liu Y","year":"2018","journal-title":"BMC Anesthesiol"},{"issue":"11","key":"ref17","first-page":"885","article-title":"A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice","volume":"44","author":"Sinclair MD","year":"2003","journal-title":"Can Vet J"},{"issue":"4","key":"ref18","first-page":"429","article-title":"Effects of dexmedetomidine on renal system and on vasopressin plasma levels. Experimental study in dogs","volume":"55","author":"Villela NR","year":"2005","journal-title":"Rev Bras Anestesiol"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","DOI":"10.1097\/CCM.0b013e3182986248","article-title":"Clonidine and dexmedetomidine increase the pressor response to norepinephrine in experimental sepsis: a pilot study","volume":"41","author":"Geloen A","year":"2013","journal-title":"Crit Care Med"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","DOI":"10.1097\/CCM.0000000000003520","article-title":"The effect of propofol and dexmedetomidine sedation on norepinephrine requirements in septic shock patients: a crossover trial","volume":"47","author":"Morelli A","year":"2019","journal-title":"Crit Care Med"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1177\/0885066618802269","article-title":"Effects from continuous infusions of dexmedetomidine and propofol on hemodynamic stability in critically Ill adult patients with septic shock","volume":"35","author":"Nelson KM","year":"2020","journal-title":"J Intensive Care Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/ALN.0000000000000491","article-title":"Dexmedetomidine attenuates the microcirculatory derangements evoked by experimental sepsis","volume":"122","author":"Miranda ML","year":"2015","journal-title":"Anesthesiology"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/SHK.0000000000001055","article-title":"Effect of dexmedetomidine on lactate clearance in patients with septic shock: a subanalysis of a multicenter randomized controlled trial","volume":"50","author":"Miyamoto K","year":"2018","journal-title":"Shock"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1056\/NEJM199510193331601","article-title":"A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group","volume":"333","author":"Gattinoni L","year":"1995","journal-title":"N Engl J Med"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/vaa.12220","article-title":"The cardiopulmonary effects of dexmedetomidine infusions in dogs during isoflurane anesthesia","volume":"42","author":"Pascoe PJ","year":"2015","journal-title":"Vet Anaesth Analg"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/bja\/aem017","article-title":"Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients","volume":"98","author":"Memi\u015f D","year":"2007","journal-title":"Br J Anaesth"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"162","DOI":"10.17305\/bjbms.2018.2400","article-title":"Dexmedetomidine reduces ventilator-induced lung injury (VILI) by inhibiting Toll-like receptor 4 (TLR4)\/nuclear factor (NF)-\u03baB signaling pathway","volume":"18","author":"Chen H","year":"2018","journal-title":"Bosn J Basic Med Sci"},{"issue":"2","key":"ref28","article-title":"Protective effects of dexmedetomidine-ketamine combination against ventilator-induced lung injury in endotoxemia rats","volume":"167","author":"Yang CL","year":"2011","journal-title":"J Surg Res"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1875-4597(09)60002-3","article-title":"Effects of dexmedetomidine on regulating pulmonary inflammation in a rat model of ventilator-induced lung injury","volume":"46","author":"Yang CL","year":"2008","journal-title":"Acta Anaesthesiol Taiwan"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/SHK.0000000000001134","article-title":"Effects of clonidine on the cardiovascular, renal, and Inflammatory responses to experimental bacteremia","volume":"51","author":"Calzavacca P","year":"2019","journal-title":"Shock"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1096\/fj.09-140798","article-title":"CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs","volume":"24","author":"Thorgersen EB","year":"2010","journal-title":"FASEB J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00540-008-0611-9","article-title":"Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats","volume":"22","author":"Taniguchi T","year":"2008","journal-title":"J Anesth"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1213\/00000539-199902000-00042","article-title":"The effects of clonidine and dexmedetomidine on human neutrophil functions","volume":"88","author":"Nishina K","year":"1999","journal-title":"Anesth Analg"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/bja\/86.5.650","article-title":"Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit","volume":"86","author":"Venn RM","year":"2001","journal-title":"Br J Anaesth"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502022000700201&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T12:12:06Z","timestamp":1668168726000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502022000700201&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022]]}},"alternative-id":["S0102-86502022000700201"],"URL":"https:\/\/doi.org\/10.1590\/acb370703","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e370703"}}