{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:07:09Z","timestamp":1790615229840,"version":"4.1.0"},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","issue":"10","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"DOI":"10.1590\/acb371002","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T16:35:37Z","timestamp":1671467737000},"source":"Crossref","is-referenced-by-count":13,"title":["Licorice zinc suppresses melanogenesis via inhibiting the activation of P38MAPK and JNK signaling pathway in Balb\/c mice skin"],"prefix":"10.1590","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4954-1823","authenticated-orcid":false,"given":"Jing-yan","family":"Wang","sequence":"first","affiliation":[{"name":"Southwest Medical University,  People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1630-8355","authenticated-orcid":false,"given":"Xing-yu","family":"Xie","sequence":"additional","affiliation":[{"name":"Southwest Medical University,  People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0696-5244","authenticated-orcid":false,"given":"Ying","family":"Deng","sequence":"additional","affiliation":[{"name":"Southwest Medical University,  People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2162-2290","authenticated-orcid":false,"given":"Hong-qiu","family":"Yang","sequence":"additional","affiliation":[{"name":"Southwest Medical University,  People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-1421","authenticated-orcid":false,"given":"Xiao-shuang","family":"Du","sequence":"additional","affiliation":[{"name":"Southwest Medical University,  People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3953-909X","authenticated-orcid":false,"given":"Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical University,  People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7522-5744","authenticated-orcid":false,"given":"Yu","family":"Du","sequence":"additional","affiliation":[{"name":"Medical University,  People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2022]]},"reference":[{"issue":"12","key":"ref1","first-page":"946","article-title":"Adverse cutaneous reaction to oral contraceptives","volume":"81","author":"Baker H.","year":"1969","journal-title":"Br J Dermatol"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jaad.2010.12.046","article-title":"Melasma: A comprehensive update Part I.","volume":"65","author":"Sheth VM","year":"2011","journal-title":"J Am Academy Dermatol"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.3390\/ijms19061640","article-title":"Downregulation of alpha-melanocyte-stimulating hormone-induced activation of the Pax3-MITF-tyrosinase axis by sorghum ethanolic extract in B16F10 melanoma cells","volume":"19","author":"Lee DH","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/pcmr.12808","article-title":"Tyrosinase-catalyzed oxidation of resveratrol produces a highly reactive ortho-quinone: Implications for melanocyte toxicity","volume":"32","author":"Ito S","year":"2019","journal-title":"Pigment Cell Melanoma Res"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/pcmr.12269","article-title":"Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism","volume":"27","author":"Sasaki M","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3390\/plants10040727","article-title":"Oenothera laciniata hill extracts exhibits antioxidant effects and attenuates melanogenesis in B16-F10 cells via downregulating CREB\/MITF\/tyrosinase and upregulating p-ERK and p-JNK","volume":"10","author":"Ko HH","year":"2021","journal-title":"Plants (Basel)"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.envres.2016.07.009","article-title":"The effect of simultaneous exposure of HEMn-DP and HEMn-LP melanocytes to nicotine and UV-radiation on the cell viability and melanogenesis","volume":"151","author":"Delijewski M","year":"2016","journal-title":"Environ Res"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.3390\/molecules25061458","article-title":"Oligomeric procyanidin nanoliposomes prevent melanogenesis and UV radiation-induced skin epithelial cell (HFF-1) damage","volume":"25","author":"Chen Y","year":"2020","journal-title":"Molecules"},{"issue":"15","key":"ref9","doi-asserted-by":"crossref","first-page":"7814","DOI":"10.3390\/ijms22157814","article-title":"Inhibitory effect of avenanthramides (Avn) on tyrosinase activity and melanogenesis in alpha-MSH-activated SK-MEL-2 cells: in vitro and in silico analysis","volume":"22","author":"Park JY","year":"2021","journal-title":"Int J Mol Sci."},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3390\/biom9100596","article-title":"Flumequine-mediated upregulation of p38 MAPK and JNK results in melanogenesis in B16F10 cells and Zebrafish larvae","volume":"9","author":"Karunarathne W","year":"2019","journal-title":"Biomolecules"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"824","DOI":"10.5483\/BMBRep.2010.43.12.824","article-title":"Beta-carboline alkaloids harmaline and harmalol induce melanogenesis through p38 mitogen-activated protein kinase in B16F10 mouse melanoma cells","volume":"43","author":"Park SY","year":"2010","journal-title":"BMB Rep"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2165\/11209070-000000000-00000","article-title":"Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis","volume":"72","author":"McCormack PL.","year":"2012","journal-title":"Drugs"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.1111\/jocd.15305","article-title":"Evaluation of oral tranexamic acid as a novel treatment for melasma with a high benefit-risk ratio","author":"Simpson J","year":"2022","journal-title":"J Cosmet Dermatol"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/jdv.12209","article-title":"Treatment of melasma with oral administration of compound tranexamic acid: a preliminary clinical trial","volume":"28","author":"Li Y","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"51","key":"ref15","doi-asserted-by":"crossref","first-page":"11147","DOI":"10.1021\/acs.jafc.7b04470","article-title":"Perspective on biotransformation and de novo biosynthesis of licorice constituents","volume":"65","author":"Zhao Y","year":"2017","journal-title":"J Agric Food Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"126854","DOI":"10.1016\/j.foodchem.2020.126854","article-title":"Quality assessment of licorice (Glycyrrhiza glabra L.) from different sources by multiple fingerprint profiles combined with quantitative analysis, antioxidant activity and chemometric methods","volume":"324","author":"Yang F","year":"2020","journal-title":"Food Chem"},{"issue":"5","key":"ref17","first-page":"4956","article-title":"Multi-pathway integrated adjustment mechanism of licorice flavonoids presenting anti-inflammatory activity","volume":"18","author":"Yu X","year":"2019","journal-title":"Oncol Lett"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3390\/antiox8100445","article-title":"Glycerolic licorice extracts as active cosmeceutical ingredients: extraction optimization, chemical characterization, and biological activity","volume":"8","author":"Ciganovic P","year":"2019","journal-title":"Antioxidants (Basel)"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1248\/bpb.b13-00276","article-title":"Rhamnetin attenuates melanogenesis by suppressing oxidative stress and pro-inflammatory mediators","volume":"36","author":"Kim YJ","year":"2013","journal-title":"Biol Pharm Bull"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00204-011-0775-1","article-title":"Zinc and human health: an update","volume":"86","author":"Chasapis CT","year":"2012","journal-title":"Arch Toxicol"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.aninu.2021.01.003","article-title":"Zinc alleviates the heat stress of primary cultured hepatocytes of broiler embryos via enhancing the antioxidant ability and attenuating the heat shock responses","volume":"7","author":"Li T","year":"2021","journal-title":"Anim Nutr"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1186\/s13063-020-04923-w","article-title":"Evaluation of the effect of curcumin and zinc co-supplementation on glycemic measurements, lipid profiles, and inflammatory and antioxidant biomarkers in overweight or obese prediabetic patients: a study protocol for a randomized double-blind placebo-controlled phase 2 clinical trial","volume":"21","author":"Karandish M","year":"2020","journal-title":"Trials"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1089\/jir.2020.0209","article-title":"The effects of zinc supplementation on C-reactive protein and inflammatory cytokines: a meta-analysis and systematical review","volume":"41","author":"Ceylan MN","year":"2021","journal-title":"J Interferon Cytokine Res"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3892\/etm.2020.9588","article-title":"DUOX2 participates in skin aging induced by UVB in HSF2 cells by activating NF-kappaB signaling","volume":"21","author":"Xiao X","year":"2021","journal-title":"Exp Ther Med"},{"key":"ref25","first-page":"2905362","article-title":"Protection against UVB-induced photoaging by Nypa fruticans via inhibition of MAPK\/AP-1\/MMP-1 signaling","volume":"2020","author":"Choi HJ","year":"2020","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4062\/biomolther.2016.276","article-title":"YJI-7 suppresses ROS production and expression of inflammatory mediators via modulation of p38MAPK and JNK signaling in RAW 264.7 macrophages","volume":"26","author":"Oh HJ","year":"2018","journal-title":"Biomol Ther (Seoul)"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.yjmcc.2011.10.013","article-title":"Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway","volume":"52","author":"Tian XY","year":"2012","journal-title":"J Mol Cell Cardiol"},{"issue":"9","key":"ref28","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.3390\/molecules22091480","article-title":"Anti-melanogenic effects of flavonoid glycosides from limonium tetragonum (Thunb.) bullock via inhibition of tyrosinase and tyrosinase-related proteins","volume":"22","author":"Lee SG","year":"2017","journal-title":"Molecules"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/exd.12248","article-title":"A novel adamantyl benzylbenzamide derivative, AP736, suppresses melanogenesis through the inhibition of cAMP-PKA-CREB-activated microphthalmia-associated transcription factor and tyrosinase expression","volume":"22","author":"Lee CS","year":"2013","journal-title":"Exp Dermatol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cbi.2016.06.010","article-title":"Afzelin positively regulates melanogenesis through the p38 MAPK pathway","volume":"254","author":"Jung E","year":"2016","journal-title":"Chem Biol Interact"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.lfs.2007.05.009","article-title":"Diosgenin inhibits melanogenesis through the activation of phosphatidylinositol-3-kinase pathway (PI3K) signaling","volume":"81","author":"Lee J","year":"2007","journal-title":"Life Sci"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502022001000201&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T15:13:10Z","timestamp":1683040390000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502022001000201&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":31,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022]]}},"alternative-id":["S0102-86502022001000201"],"URL":"https:\/\/doi.org\/10.1590\/acb371002","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e371002"}}