{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:04:09Z","timestamp":1782122649121,"version":"3.54.5"},"reference-count":52,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"DOI":"10.1590\/acb385123","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T14:47:05Z","timestamp":1701442025000},"source":"Crossref","is-referenced-by-count":6,"title":["Emodin inhibits bladder inflammation and fibrosis in mice with interstitial cystitis by regulating JMJD3"],"prefix":"10.1590","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8325-8765","authenticated-orcid":false,"given":"Junyu","family":"Lai","sequence":"first","affiliation":[{"name":"Southwest Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2544-2865","authenticated-orcid":false,"given":"Xing","family":"Liu","sequence":"additional","affiliation":[{"name":"Southwest Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5945-5435","authenticated-orcid":false,"given":"Hongwei","family":"Su","sequence":"additional","affiliation":[{"name":"Southwest Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1863-4881","authenticated-orcid":false,"given":"Yongsheng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Southwest Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1124-549X","authenticated-orcid":false,"given":"Ke","family":"Xin","sequence":"additional","affiliation":[{"name":"Southwest Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1600-422X","authenticated-orcid":false,"given":"Mingwei","family":"Huang","sequence":"additional","affiliation":[{"name":"Southwest Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0626-4551","authenticated-orcid":false,"given":"Songtao","family":"Luo","sequence":"additional","affiliation":[{"name":"Southwest Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3572-8156","authenticated-orcid":false,"given":"Hai","family":"Tang","sequence":"additional","affiliation":[{"name":"Southwest Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.jconrel.2022.06.045","article-title":"Superior therapeutic activity of TGF-\u03b2-induced extracellular vesicles against interstitial cystitis","volume":"348","author":"Song K","year":"2022","journal-title":"J Control Release"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2077039598","DOI":"10.1177\/1756287218818030","article-title":"Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis","volume":"11","author":"Tudrej KB","year":"2019","journal-title":"Ther Adv Urol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"111522","DOI":"10.1016\/j.biopha.2021.111522","article-title":"Therapeutic effect of modulating the NLRP3-regulated transforming growth factor-\u03b2 signaling pathway on interstitial cystitis\/bladder pain syndrome","volume":"138","author":"Shih HJ","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"ref4","series-title":"WHO International Agency for Research on Cancer Monograph Working Group. A review of human carcinogens--part C: metals, arsenic, dusts, and fibres","author":"Straif K","year":"2009"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"903834","DOI":"10.3389\/fimmu.2022.903834","article-title":"The NLRP3 Inflammasome Inhibitor Dapansutrile Attenuates Cyclophosphamide-Induced Interstitial Cystitis","volume":"13","author":"Kiran S","year":"2022","journal-title":"Front Immunol"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/iju.14229","article-title":"Interstitial cystitis\/bladder pain syndrome: The evolving landscape, animal models and future perspectives","volume":"27","author":"Akiyama Y","year":"2020","journal-title":"Int J Urol"},{"issue":"7203","key":"ref7","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov R.","year":"2008","journal-title":"Nature"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/his.13235","article-title":"Histopathological characteristics of interstitial cystitis\/bladder pain syndrome without Hunner lesion","volume":"71","author":"Kim A","year":"2017","journal-title":"Histopathology"},{"issue":"7411","key":"ref9","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nature11262","article-title":"A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response","volume":"488","author":"Kruidenier L","year":"2012","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.intimp.2018.03.027","article-title":"JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis","volume":"59","author":"Chen Y","year":"2018","journal-title":"Int Immunopharmacol"},{"issue":"14","key":"ref11","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1093\/cvr\/cvy176","article-title":"Critical role of histone demethylase Jumonji domain-containing protein 3 in the regulation of neointima formation following vascular injury","volume":"114","author":"Luo X","year":"2018","journal-title":"Cardiovasc Res"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1096\/fj.201701483R","article-title":"Histone demethylase JMJD3 regulates fibroblast-like synoviocyte-mediated proliferation and joint destruction in rheumatoid arthritis","volume":"32","author":"Jia W","year":"2018","journal-title":"Faseb J"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.juro.2008.10.145","article-title":"Epigenetic reprogramming: a possible etiological factor in bladder pain syndrome\/interstitial cystitis?","volume":"181","author":"Elgavish A.","year":"2009","journal-title":"J Uro"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"113555","DOI":"10.1016\/j.biopha.2022.113555","article-title":"Recent advances in the therapeutic potential of emodin for human health","volume":"154","author":"Sharifi-Rad J","year":"2022","journal-title":"Biomed Pharmacother"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.3390\/ijms19092532","article-title":"Targeting TGF-\u03b2 Signaling in Kidney Fibrosis","volume":"19","author":"Isaka Y.","year":"2018","journal-title":"Int J Mol Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2017.12.016","article-title":"Inflammation and renal fibrosis: Recent developments on key signaling molecules as potential therapeutic targets","volume":"820","author":"Lv W","year":"2018","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.bcp.2005.04.026","article-title":"Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway","volume":"70","author":"Su YT","year":"2005","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1159\/000492544","article-title":"Emodin and Its Combination with Cytarabine Induce Apoptosis in Resistant Acute Myeloid Leukemia Cells in Vitro and in Vivo","volume":"48","author":"Chen Y","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"102394","DOI":"10.1016\/j.pdpdt.2021.102394","article-title":"Effects of photodynamic therapy mediated by emodin in cervical carcinoma cells","volume":"35","author":"Galiardi-Campoy A","year":"2021","journal-title":"Photodiagn Photodyn"},{"issue":"11","key":"ref20","first-page":"1142","article-title":"Emodin induces leukemic HL-60 cells apoptosis probably by inhibiting Akt signal pathway","volume":"42","author":"Zheng HY","year":"2007","journal-title":"Yao Xue Xue Bao"},{"issue":"3","key":"ref21","first-page":"505","article-title":"Emodin inhibits extracellular matrix synthesis by suppressing p38 and ERK1\/2 pathways in TGF-\u03b21-stimulated NRK-49F cells","volume":"4","author":"Zhu B","year":"2011","journal-title":"Mol Med Rep"},{"key":"ref22","first-page":"41","article-title":"Regulatory effects of emodin on NF-kappaB activation and inflammatory cytokine expression in RAW 264.7 macrophages","volume":"11","author":"Li HL","year":"2005","journal-title":"Int J Mol Med"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.jep.2014.03.059","article-title":"Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages","volume":"153","author":"Hu B","year":"2014","journal-title":"J Ethnopharmacol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"903239","DOI":"10.3389\/fphar.2022.903239","article-title":"Research Status and Hotspots of Anticancer Natural Products Based on the Patent Literature and Scientific Articles","volume":"13","author":"Shen J","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.actbio.2015.02.030","article-title":"Hyaluronic acid decreases IL-6 and IL-8 secretion and permeability in an inflammatory model of interstitial cystitis","volume":"19","author":"Rooney P","year":"2015","journal-title":"Acta Biomater"},{"issue":"14","key":"ref26","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1111\/bph.13501","article-title":"F16357, a novel protease-activated receptor 1 antagonist, improves urodynamic parameters in a rat model of interstitial cystitis","volume":"173","author":"Monjotin N","year":"2016","journal-title":"Brit J Pharmacol"},{"issue":"21","key":"ref27","doi-asserted-by":"crossref","first-page":"12053","DOI":"10.3390\/ijms222112053","article-title":"B6 Mouse Strain: The Best Fit for LPS-Induced Interstitial Cystitis Model","volume":"22","author":"Chen CH","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"9","key":"ref28","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1016\/j.bbadis.2019.05.008","article-title":"Activation of NFKB-JMJD3 signaling promotes bladder fibrosis via boosting bladder smooth muscle cell proliferation and collagen accumulation","volume":"1865","author":"Lai J","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"909557","DOI":"10.3389\/fcell.2022.909557","article-title":"Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs","volume":"10","author":"Lee M","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s00432-018-2631-7","article-title":"Therapeutic potential of GSK-J4, a histone demethylase KDM6B\/JMJD3 inhibitor, for acute myeloid leukemia","volume":"144","author":"Li Y","year":"2018","journal-title":"J Cancer Res Clin Oncol"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/j.juro.2012.01.034","article-title":"Urinary chemokines as noninvasive predictors of ulcerative interstitial cystitis","volume":"187","author":"Tyagi P","year":"2012","journal-title":"J Urol"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/1756287211398255","article-title":"Role of inflammation in bladder function and interstitial cystitis","volume":"3","author":"Grover S","year":"2011","journal-title":"Ther Adv Urol"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/his.13235","article-title":"Histopathological characteristics of interstitial cystitis\/bladder pain syndrome without Hunner lesion","volume":"71","author":"Kim A","year":"2017","journal-title":"Histopathology"},{"issue":"10","key":"ref34","doi-asserted-by":"crossref","first-page":"566","DOI":"10.21037\/atm-22-1397","article-title":"Interference with connective tissue growth factor attenuated fibroblast-to-myofibroblast transition and pulmonary fibrosis","volume":"10","author":"Yang Z","year":"2022","journal-title":"Ann Transl Med"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"340","DOI":"10.21037\/cdt-21-724","article-title":"Downregulation of interleukin-1 beta via Jmjd3 inhibition improves post-myocardial infarction depression","volume":"12","author":"Tang X","year":"2022","journal-title":"Cardiovasc Diagn Ther"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41368-022-00190-4","article-title":"Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1","volume":"14","author":"Jin Y","year":"2022","journal-title":"Int J Oral Sci"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5213\/inj.1632522.261","article-title":"Update on the Pathology and Diagnosis of Interstitial Cystitis\/Bladder Pain Syndrome: A Review","volume":"20","author":"Kim HJ","year":"2016","journal-title":"Int Neurourol J"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"102381","DOI":"10.1016\/j.redox.2022.102381","article-title":"Nox4 promotes endothelial differentiation through chromatin remodeling","volume":"55","author":"Hahner F","year":"2022","journal-title":"Redox Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"115165","DOI":"10.1016\/j.bcp.2022.115165","article-title":"Novel pharmacological inhibition of JMJD3 improves necrotizing enterocolitis by attenuating the inflammatory response and ameliorating intestinal injury","volume":"203","author":"Ma S","year":"2022","journal-title":"Biochem Pharmacol"},{"issue":"9","key":"ref40","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1016\/j.bbadis.2019.05.008","article-title":"Activation of NFKB-JMJD3 signaling promotes bladder fibrosis via boosting bladder smooth muscle cell proliferation and collagen accumulation","volume":"1865","author":"Lai J","year":"2019","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"ref41","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201839","article-title":"Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms","volume":"218","author":"Davis FM","year":"2021","journal-title":"J Exp Med"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41389-021-00307-0","article-title":"Epigenetic regulation of TGF-\u03b2-induced EMT by JMJD3\/KDM6B histone H3K27 demethylase","volume":"10","author":"Lee SH","year":"2021","journal-title":"Oncogenesis"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-beta signaling from cell membrane to the nucleus","volume":"113","author":"Shi Y","year":"2003","journal-title":"Cell"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1083\/jcb.200403050","article-title":"Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse","volume":"166","author":"Liebner S","year":"2004","journal-title":"J Cell Biol"},{"issue":"4","key":"ref45","first-page":"577","article-title":"TGFbeta induces transdifferentiation of iBREC to alphaSMA-expressing cells","volume":"18","author":"Deissler H","year":"2006","journal-title":"Int J Mol Med"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1042\/BJ20101500","article-title":"Transforming growth factor-\u03b22 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling","volume":"437","author":"Medici D","year":"2011","journal-title":"Biochem J"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13020-018-0192-y","article-title":"Anticancer drug discovery from Chinese medicinal herbs","volume":"13","author":"Huang MY","year":"2018","journal-title":"Chin Med"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.synbio.2020.05.003","article-title":"An aurora of natural products-based drug discovery is coming","volume":"5","author":"Tong Y","year":"2020","journal-title":"Synth Syst Biotechnol"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3390\/antiox11061179","article-title":"Megalobrama amblycephala Protective Effects of Emodin on Oxidized Fish Oil-Induced Metabolic Disorder and Oxidative Stress through Notch-Nrf2 Crosstalk in the Liver of Teleost","volume":"11","author":"Song C","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"G383","DOI":"10.1152\/ajpgi.00303.2021","article-title":"Emodin reduces tumor burden by diminishing M2-like macrophages in colorectal cancer","volume":"322","author":"Sougiannis AT","year":"2022","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1038\/ncomms5696","article-title":"TSC1 controls macrophage polarization to prevent inflammatory disease","volume":"5","author":"Zhu L","year":"2014","journal-title":"Nat Commun"},{"issue":"11","key":"ref52","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1016\/j.immuni.2021.09.010","article-title":"IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation","volume":"54","author":"Faas M","year":"2021","journal-title":"Immunity"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502023000100247&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T15:30:39Z","timestamp":1702308639000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502023000100247&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":52,"alternative-id":["S0102-86502023000100247"],"URL":"https:\/\/doi.org\/10.1590\/acb385123","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"e385123"}}