{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:37:41Z","timestamp":1764333461619,"version":"3.41.2"},"reference-count":45,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["304382\/2020-5"],"award-info":[{"award-number":["304382\/2020-5"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["401672\/2023-9"],"award-info":[{"award-number":["401672\/2023-9"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Conselho Nacional de Pesquisa e Desenvolvimento Cient\u00edfico","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Conselho Nacional de Pesquisa e Desenvolvimento Cient\u00edfico","award":["304382\/2020-5"],"award-info":[{"award-number":["304382\/2020-5"]}]},{"name":"Conselho Nacional de Pesquisa e Desenvolvimento Cient\u00edfico","award":["401672\/2023-9"],"award-info":[{"award-number":["401672\/2023-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: Bioactive molecules are relevant to fight cancer and associated conditions. Quinoxaline is a privileged N-heterocycle, notably as anticancer agents. Herein, we report the evaluation of the quinoxaline derivatives DEQX and OAQX as anticancer agents, as well as in function of their anti-inflammatory and analgesic activities.  Methods: Quinoxalines were synthesized and tested as anticancer agents based on cell viability and Annexin V-FITC apoptosis. Anti-inflammatory activity was evaluated from mouse carrageenan peritonitis and levels of interleukin (IL)-1\u03b2 and tumor necrosis factor (TNF)-alfa for enzyme-linked immunosorbent assay. Hot-plate and acetic acid-induced writing test were employed to investigate analgesia.  Results: Both reduced the Ht-29 cell viability in a dependent-concentration manner (p &lt; 0.001). Total apoptosis was detected for cells treated with 12.5 and 25 \u00b5g\/mL of both the compounds for 24 and 48 h (all doses, p &lt; 0.0001). DEQX (all doses, p &lt; 0.01) and OAQX (all doses, p &lt; 0.001) acted in leukocyte migration and decreased the IL-1\u03b2 and TNF-\u03b2 levels (p &lt; 0.05). DEQX (all doses, p &lt; 0.05) and OAQX (5mg\/kg, p &lt; 0.001) showed peripheral analgesic effect.  Conclusions: In-vitro and in-vivo results suggest that these quinoxalines are promising for application in pharmacological area due to their anticancer, anti-inflammatory, and peripheric analgesia.<\/jats:p>","DOI":"10.1590\/acb395124","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T10:57:02Z","timestamp":1723028222000},"source":"Crossref","is-referenced-by-count":3,"title":["Anticancer, anti-inflammatory and analgesic activities of aminoalcohol-based quinoxaline small molecules"],"prefix":"10.1590","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-1523","authenticated-orcid":false,"given":"Jannyely Moreira","family":"Neri","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4379-8256","authenticated-orcid":false,"given":"Paula Em\u00edlia Apol\u00f4nio","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8692-9352","authenticated-orcid":false,"given":"Ana Luiza Cabral de S\u00e1 Leit\u00e3o","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5514-5192","authenticated-orcid":false,"given":"Renata Mendon\u00e7a","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2349-2354","authenticated-orcid":false,"given":"Raimundo Fernandes de","family":"Ara\u00fajo J\u00fanior","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil; Universidade Federal do Rio Grande do Norte,  Brazil; Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6245-0742","authenticated-orcid":false,"given":"Agnes Andrade","family":"Martins","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7731-2867","authenticated-orcid":false,"given":"Isabelle de Lima","family":"Marques","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5123-0741","authenticated-orcid":false,"given":"Rafaela Alcindo","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9264-4695","authenticated-orcid":false,"given":"Aurigena Antunes de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil; Universidade Federal do Rio Grande do Norte,  Brazil; Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2153-1647","authenticated-orcid":false,"given":"Fabr\u00edcio Gava","family":"Menezes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1039\/c4an00296b","article-title":"The use of EEM fluorescence data and OPLS\/UPLS- DA algorithm to 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