{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:35:46Z","timestamp":1790742946915,"version":"4.1.0"},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2011\/51873-9"],"award-info":[{"award-number":["2011\/51873-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To establish a profile of the inflammatory response in the preoperative and postoperative period of pulmonary resection of patients without postoperative complications, in order to trace the inflammatory profile of lung resection surgery.  Methods: Six collections of arterial and venous blood were performed for data analysis, one sample in the preoperative, immediate postoperative, 4, 8, 24, and 48 hours after surgery. Twenty-seven patients with a median age of 63 years old, ranging from 29 to 80 years old, were included.  Results: The leukocyte count showed a significant increase in the times: immediate postoperative and 4 hours after surgery, in relation to the preoperative period. Concomitantly, there was an increase in lactate, heart rate, interleukin (IL)-6 and IL-8 after 4 hours of surgery. The platelet count showed a significant decrease in 48 h, associated with an increase in IL-1\u03b2 and tumor necrosis factor-\u03b1. A significant increase in IL-10 was observed in the immediate postoperative.  Conclusion: The study may contribute to the search for more specific and adequate alternatives for controlling the inflammatory response. In this way, the intervention would be specific to that cytokine that causes the greatest harm to the patient, as well as to the moment of the intervention.<\/jats:p>","DOI":"10.1590\/acb401625","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T11:30:40Z","timestamp":1738582240000},"source":"Crossref","is-referenced-by-count":1,"title":["Acute inflammatory profile of patients submitted to pulmonary resection"],"prefix":"10.1590","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5666-4937","authenticated-orcid":false,"given":"Andrea Pelicia Roso de","family":"Souza","sequence":"first","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7445-0907","authenticated-orcid":false,"given":"Raquel","family":"Palhares","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0073-0287","authenticated-orcid":false,"given":"Let\u00edcia","family":"Baltieri","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1953-2202","authenticated-orcid":false,"given":"Ricardo Kalaf","family":"Mussi","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2201-8247","authenticated-orcid":false,"given":"Edson","family":"Antunes","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9468-6108","authenticated-orcid":false,"given":"Glaucia Coelho de","family":"Mello","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.soc.2016.02.001","article-title":"Epidemiology of lung cancer","volume":"25","author":"Mao Y","year":"2016","journal-title":"Surg Oncol Clin N Am"},{"issue":"13","key":"ref2","article-title":"Risk factors of postoperative acute lung injury following lobectomy for nonsmall cell lung cancer","volume":"98","author":"Kim HJ","year":"2019","journal-title":"Medicine"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/resp.12662","article-title":"Systemic inflammation and oxidative stress post-lung resection: effect of pretreatment with N-acetylcysteine","volume":"21","author":"Bastin A","year":"2016","journal-title":"Respirology"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/10623320601061862","article-title":"The endothelium and inflammation","volume":"13","author":"Trepels T","year":"2006","journal-title":"Endothelium"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1183\/09031936.00015607","article-title":"Exercise training reduces pulmonar yischaemia-reperfusion-induced inflammatory responses","volume":"31","author":"Mussi RK","year":"2008","journal-title":"Eur Respirat J"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0003-4975(00)01258-3","article-title":"VATS lobectomy reduces cytokine responses compared with conventional surgery","volume":"70","author":"Yim AP","year":"2000","journal-title":"Ann Thorac Surg"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1136\/thx.2009.123083","article-title":"Postoperative pulmonary complications following thoracic surgery: are there any modifiable risk factors?","volume":"65","author":"Agostini P","year":"2010","journal-title":"Thorax"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1053\/j.jvca.2011.09.028","article-title":"Characterization of pulmonary and systemic inflammatory responses produced by lung re-expansion after one-lung ventilation","volume":"26","author":"Leite CF","year":"2012","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.ejcts.2004.07.015","article-title":"Preoperative chemotherapy increases cytokine production after lung cancer surgery","volume":"26","author":"Endo S","year":"2004","journal-title":"Eur J Cardiothorac Surg"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/0885066610384188","article-title":"Interleukin-6 in surgery, trauma, and critical care part: p II, In: Clinical implications","volume":"26","author":"Jawa RS","year":"2011","journal-title":"J Intensive Care Med"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/bja\/aei143","article-title":"Procalcitonin, interleukin 6 and systemic inflammatory response syndrome: early markers of postoperative sepsis after major surgery","volume":"94","author":"Mokard D","year":"2005","journal-title":"Br J Anaesth"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199807","article-title":"Perioperative cytokine profile during lung surgery predicts patients at risk for postoperative complications-A prospective, clinical study","volume":"13","author":"Kaufmann KB","year":"2018","journal-title":"PLoS One"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/ejcts\/ezu395","article-title":"Role of cytokine pro\ufb01le in the differential diagnosis between acute lung rejection and pulmonary infections after lung transplantation","volume":"47","author":"Patella M","year":"2015","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/820304","article-title":"Development and validation of protein microarray technology for simultaneous inflammatory mediator detection in human sera","author":"Selvarajah S","year":"2014","journal-title":"Mediators In\ufb02amm"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/icvts\/ivv206","article-title":"Elevated inflammatory parameters and inflammation scores are associated with poor prognosis in patients under going pulmonary metastasectomy for colorectal cancer","volume":"21","author":"Ghanim B","year":"2015","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079207","article-title":"Cytokines and signaling molecules predict clinical outcomes in sepsis","volume":"8","author":"Fjell CD","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jcrc.2005.07.001","article-title":"Systemic inflammatory response syndrome and surgical stress in thoracic surgery","volume":"21","author":"Takenaka K","year":"2006","journal-title":"J Crit Care"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/resp.12662","article-title":"Systemic inflammation and oxidative stress post-lung resection: Effect of pretreatment with N-acetylcysteine","volume":"21","author":"Bastin AJ","year":"2016","journal-title":"Respirology"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.surg.2016.04.004","article-title":"Clinical impact of interleukin 6 as a predictive biomarker in the early diagnosis of postoperative systemic inflammatory responde syndrome after major thoracic surgery: a prospective clinical trial","volume":"160","author":"Fink-Neuboeck N","year":"2016","journal-title":"Surgery"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.bjan.2018.12.009","article-title":"Valor preditivo das citocinas plasm\u00e1ticas para les\u00e3o renal aguda ap\u00f3s cirurgia de ressec\u00e7\u00e3o pulmonar: estudo observacional prospectivo","volume":"69","author":"Matesanz MC","year":"2019","journal-title":"Rev Bras Anestesiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1476-9255-8-32","article-title":"Cytokine & chemokine response in the lungs, pleural fluid and serum in thoracic surgery using one-lung ventilation","volume":"8","author":"Breunig A","year":"2011","journal-title":"J Inflamm (Lond)"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1097\/EJA.0000000000000233","article-title":"Systemic and alveolar inflammatory response in the dependent and nondependent lung in patients undergoing lung resection surgery: A prospective observational study","volume":"32","author":"de la Gala F","year":"2015","journal-title":"Eur J Anaesthesiol"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s00540-011-1100-0","article-title":"The effect of one-lung ventilation upon pulmonary inflammatory responses during lung resection","volume":"25","author":"Sugasawa Y","year":"2011","journal-title":"J Anesth"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502025000100802&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T11:30:49Z","timestamp":1738582249000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502025000100802&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":23,"alternative-id":["S0102-86502025000100802"],"URL":"https:\/\/doi.org\/10.1590\/acb401625","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e401625"}}