{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:36:14Z","timestamp":1754159774654,"version":"3.41.2"},"reference-count":33,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science & Technology Development Fund of Tianjin Education Commission for Higher Education","award":["2020KJ192"],"award-info":[{"award-number":["2020KJ192"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: We builted a orthotopic autologous liver transplantation (OALT) model in rats to evaluate the possible mechanisms of berberine against lung injury.  Methods: Forty clean grade Sprague-Dawley rats (male, healthy, 250\u2013280 g) were divided into five groups (n = 8): sham-operated group (group S), orthotopic autologous liver transplantation group (group T), berberine group (group B), peroxisome proliferator-activated receptor gamma (PPAR\u03b3) inhibitor GW9662 group (group G), and berberine + GW9662 group (group B+G). In group S, the relevant tissues around the liver were dissociated only. Orthotopic autologous liver transplantation was used in other groups, berberine 200 mg\/kg\/day was given one week before surgery in group B and group B+G. GW9662 1 mg\/kg was intraperitoneally injected in group G and group B+G 4 hours before surgery. Blood samples were obtained for detecting PaO2 and the concentration of serum clam cell protein (CC16), surfactant protein-D (SP-D), interleukin (IL)-1\u03b2 and IL-18. The immunohistochemical method detects the expression of PPAR\u03b3 and nuclear factor-kappa B (NF-\u03baB) in lung tissues. The expression of PPAR\u03b3, NF-\u03baBand pyroptosis-related proteins were analysed by western blotting.  Results: Rats exhibited increased histological lung injury following OALT. Liver transplantation caused upregulated CC16, SP-D, IL-18 and IL-1\u03b2 levels, reduced PaO2 and the PPAR\u03b3 expression, upregulated the NF-\u03baB and pyroptosis-related protein expressions. BBR pretreatment greatly alleviates these lung damages induced by OALT. However, administration of GW9662 partially reversed the beneficial effects of BBR on lung injury.  Conclusion: Berberine may play protective capacities against lung injury by upregulating PPAR\u03b3 to downregulate the NF-\u03baB-mediated pyroptosis pathway.<\/jats:p>","DOI":"10.1590\/acb404925","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T01:24:34Z","timestamp":1753493074000},"source":"Crossref","is-referenced-by-count":0,"title":["Berberine protects against lung injury induced by liver transplantation through upregulating PPAR\u03b3 and suppressing NF-\u03baB-mediated pyroptosis pathway"],"prefix":"10.1590","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8654-5463","authenticated-orcid":false,"given":"Wenna","family":"Liu","sequence":"first","affiliation":[{"name":"Tianjin Medical University,  China; Tianjin Institute of Endocrinology,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1432-2572","authenticated-orcid":false,"given":"Xiaohui","family":"Liang","sequence":"additional","affiliation":[{"name":"Tianjin Medical University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6882-4261","authenticated-orcid":false,"given":"Mingxia","family":"Huo","sequence":"additional","affiliation":[{"name":"Tianjin Medical University,  China; Tianjin Institute of Endocrinology,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1281-9107","authenticated-orcid":false,"given":"Yongwang","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guilin Medical University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8682-5743","authenticated-orcid":false,"given":"Guanghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Medical University,  China; Tianjin Institute of Endocrinology,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3949\/ccjm.81a.14018","article-title":"Acute respiratory distress syndrome: Implications of recent studies","volume":"81","author":"Duggal A","year":"2014","journal-title":"Cleve Clin J Med"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1016\/j.transproceed.2006.08.090","article-title":"Pulmonary complications following adult liver transplantation","volume":"38","author":"Hong SK","year":"2006","journal-title":"Transplant 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acute respiratory distress syndrome phenotypes predict 90-day mortality: a reanalysis of the fluids and catheter treatment trial","volume":"4","author":"Chase A","year":"2022","journal-title":"Crit Care Explor"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1007\/s00068-022-01997-w","article-title":"Club cell protein (CC)16 as potential lung injury marker in a porcine 72 h polytrauma model","volume":"48","author":"Greven J","year":"2022","journal-title":"Eur J Trauma Emerg Surg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"9281605","DOI":"10.1155\/2019\/9281605","article-title":"Surfactant protein D is altered in experimental malaria-associated acute lung injury\/acute respiratory distress syndrome","volume":"2019","author":"Punsawad C","year":"2019","journal-title":"J Trop Med"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/ppul.25776","article-title":"Surfactant protein D is a biomarker 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Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502025000100233&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T01:24:39Z","timestamp":1753493079000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502025000100233&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":33,"alternative-id":["S0102-86502025000100233"],"URL":"https:\/\/doi.org\/10.1590\/acb404925","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"type":"electronic","value":"1678-2674"},{"type":"print","value":"0102-8650"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e404925"}}