{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T17:07:27Z","timestamp":1761239247920,"version":"3.41.2"},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["21bk0104094h0003"],"award-info":[{"award-number":["21bk0104094h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To detail a technique to implant a double-lumen catheter to remove anti-pig antibodies. We transplanted fetal pig kidneys into cynomolgus monkeys using a double filtration plasma exchange (DFPP) protocol.  Methods: Two approaches for double-lumen catheter insertion in monkeys (3\u20139.2 kg) were developed. DFPP was performed using hydroxyethyl starch (6%) as a replacement fluid. We transplanted fetal porcine kidneys, administered immunosuppressive agents, and evaluated the grafts.  Results: The catheter insertion site was large, with postoperative hemostasis similar to blind subcutaneous puncture. Monkeys tolerated DFPP well, maintaining stable blood pressure. The technique reduced anti-pig antibodies by 67%, though acute rejection was not fully suppressed.  Conclusion: A safe technique for double-lumen catheter placement in cynomolgus monkeys was developed, along with a DFPP protocol for reducing anti-pig antibodies.<\/jats:p>","DOI":"10.1590\/acb405125","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T15:32:24Z","timestamp":1753198344000},"source":"Crossref","is-referenced-by-count":1,"title":["Application of double filtration plasmapheresis to cynomolgus monkeys: surgical techniques and a pilot study of pig fetal kidney transplantation"],"prefix":"10.1590","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2488-5719","authenticated-orcid":false,"given":"Genki","family":"Watanabe","sequence":"first","affiliation":[{"name":"The Jikei University,  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1125-0384","authenticated-orcid":false,"given":"Maiko","family":"Horikawa","sequence":"additional","affiliation":[{"name":"The Jikei University,  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9856-0852","authenticated-orcid":false,"given":"Izumi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"The Jikei University,  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4361-649X","authenticated-orcid":false,"given":"Tomohisa","family":"Endo","sequence":"additional","affiliation":[{"name":"The Jikei University,  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8431-141X","authenticated-orcid":false,"given":"Takashi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"The Jikei University,  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1241-2765","authenticated-orcid":false,"given":"Akinori","family":"Hiratsuka","sequence":"additional","affiliation":[{"name":"The Jikei University,  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8128-4006","authenticated-orcid":false,"given":"Tsuyoshi","family":"Takamura","sequence":"additional","affiliation":[{"name":"The Jikei University,  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2897-2285","authenticated-orcid":false,"given":"Kenji","family":"Matsui","sequence":"additional","affiliation":[{"name":"The Jikei University,  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2498-8055","authenticated-orcid":false,"given":"Naoto","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"The Jikei University,  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-9527","authenticated-orcid":false,"given":"Yatsumu","family":"Saito","sequence":"additional","affiliation":[{"name":"The Jikei University,  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-9923","authenticated-orcid":false,"given":"Hiroshi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"The Jikei University,  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4509-2346","authenticated-orcid":false,"given":"Akihiko","family":"Kiyoshi","sequence":"additional","affiliation":[{"name":"Sumitomo Pharma Co. 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