{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T15:05:31Z","timestamp":1762787131172,"version":"build-2065373602"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To evaluate the regenerative efficacy of an experimental biodegradable nerve conduit composed of polycaprolactone and a\u00e7a\u00ed-derived polyurethane, used for peripheral nerve repair, in comparison with different reconstructive techniques.  Methods: Wistar rats (n = 48) were allocated into six groups (n = 8): normality (NG), denervated (DG), burial (BG), nerve autograft (NAG), a\u00e7a\u00ed-based neurotube (ANG), and vein autograft (VAG). Sciatic functional index, electrophysiological parameters, and histomorphometry were assessed after 12 weeks.  Results: NAG and ANG showed significant functional recovery, with ANG being the only group to demonstrate progressive improvement (p = 0.009). Electrophysiological analysis revealed higher amplitude and lower latency in NAG, followed by ANG and VAG. Histomorphometric analysis showed increased axonal density in ANG and NAG compared to non-reconstructed groups (p = 0.004 and p = 0.007, respectively).  Conclusion: The polycaprolactone\/a\u00e7a\u00ed-based conduit demonstrated regenerative performance comparable to autologous nerve grafts.<\/jats:p>","DOI":"10.1590\/acb407725","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T15:01:57Z","timestamp":1762786917000},"source":"Crossref","is-referenced-by-count":0,"title":["Peripheral nerve regeneration using a biodegradable conduit from a\u00e7a\u00ed (Euterpe oleracea): a bio-based alternative to autografts"],"prefix":"10.1590","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4841-2894","authenticated-orcid":false,"given":"Rui Sergio Monteiro de","family":"Barros","sequence":"first","affiliation":[{"name":"Hospital Porto Dias,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-0359","authenticated-orcid":false,"given":"Deivid Ramos dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Hospital Porto Dias,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4872-1731","authenticated-orcid":false,"given":"Vitor Nagai","family":"Yamaki","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5079-297X","authenticated-orcid":false,"given":"Renan Kleber Costa","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Par\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8719-5530","authenticated-orcid":false,"given":"Andr\u00e9 Lopes","family":"Valente","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Par\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5842-8013","authenticated-orcid":false,"given":"Tiago 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