{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:26:25Z","timestamp":1790508385062,"version":"4.1.0"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"crossref","award":["ORF-2025-371"],"award-info":[{"award-number":["ORF-2025-371"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To investigate the potential protective effects of ononin on cecal ligation puncture (CLP) induced sepsis rat model.  Methods: CLP was used to induce sepsis in rats and then treated with ononin at doses of 25 and 50 mg\/kg intraperitoneally for seven days. The daily assessment included measurements of food and water intake, as well as body weight in the different rat groups. The study also examined the effects of ononin on survival rates, level of tumor necrosis factor (TNF)-\u03b1, interleukin (IL)-16, IL-6, C-reactive protein in the serum, and markers of oxidative stress in tissue homogenates of rats. The weight of spleen and lung tissue were also estimated in ononin-treated sepsis group. Additionally, histopathological examinations of lung and liver tissues were conducted in sepsis rats using hematoxylin and eosin staining.  Results: The ononin-treated group showed significant improvements in food and water intake, as well as body weight, compared to the sepsis group of rats. Survival rate was also improved in the ononin-treated group. Ononin ameliorates oxidative stress and inflammatory mediators in sepsis rats. Histopathological changes (liver and lung tissue) were observed to be ameliorated in the group of rats treated with ononin versus the sepsis group.  Conclusion: Ononin enhances survival rate in sepsis in rats by reducing inflammation and oxidative stress.<\/jats:p>","DOI":"10.1590\/acb407825","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:17:14Z","timestamp":1762859834000},"source":"Crossref","is-referenced-by-count":2,"title":["Ononin promotes survival rate in cecal ligation puncture-induced sepsis rat model by regulating inflammatory pathway"],"prefix":"10.1590","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2960-4046","authenticated-orcid":false,"given":"Bo","family":"Liu","sequence":"first","affiliation":[{"name":"Xianyang Central Hospital,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8673-742X","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Shaanxi University of Traditional Chinese Medicine,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0256-6058","authenticated-orcid":false,"given":"Ying","family":"Duan","sequence":"additional","affiliation":[{"name":"Xianyang Central Hospital,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6389-9146","authenticated-orcid":false,"given":"Shaik Althaf","family":"Hussain","sequence":"additional","affiliation":[{"name":"King Saud University,  Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7070-4933","authenticated-orcid":false,"given":"Alok Shiomurti","family":"Tripathi","sequence":"additional","affiliation":[{"name":"ERA University,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9499-6859","authenticated-orcid":false,"given":"Kang","family":"Li","sequence":"additional","affiliation":[{"name":"Xianyang Central Hospital,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.45","article-title":"Sepsis and septic shock","volume":"2","author":"Hotchkiss RS","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1038\/s41467-019-11147-3","article-title":"IFN-\u03b3 selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation","volume":"10","author":"Kang K","year":"2019","journal-title":"Nat Commun"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"105493","DOI":"10.1016\/j.micpath.2022.105493","article-title":"Protective effect of vanillin on the management of cecal ligation and puncture induced sepsis rat model","volume":"165","author":"Tripathi AS","year":"2022","journal-title":"Microb Pathog"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/13510002.2021.1891808","article-title":"Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome","volume":"26","author":"Toro-P\u00e9rez J","year":"2021","journal-title":"Redox Rep"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans L","year":"2021","journal-title":"Intensive Care Med"},{"issue":"18","key":"ref6","doi-asserted-by":"crossref","first-page":"10394","DOI":"10.3390\/ijms231810394","article-title":"Therapeutic potential and mechanisms of novel simple o-substituted isoflavones against cerebral ischemia reperfusion","volume":"23","author":"Yang SE","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/13880209.2021.1874028","article-title":"A review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents","volume":"59","author":"Marefati N","year":"2021","journal-title":"Pharm Biol"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11306-019-1614-2","article-title":"The anti-inflammatory effects of formononetin and ononin on lipopolysaccharide-induced zebrafish models based on lipidomics and targeted transcriptomics","volume":"15","author":"Luo L","year":"2019","journal-title":"Metabolomics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"104248","DOI":"10.1016\/j.phrs.2019.04.032","article-title":"Ononin, sec-O-\u03b2-d-glucosylhamaudol and astragaloside I: antiviral lead compounds identified via high throughput screening and biological validation from traditional Chinese medicine Zhongjing formulary","volume":"145","author":"Yu Y","year":"2019","journal-title":"Pharmacol Res"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12906-022-03504-5","article-title":"Ononin ameliorates inflammation and cartilage degradation in rat chondrocytes with IL-1\u03b2-induced osteoarthritis by downregulating the MAPK and NF-\u03baB pathways","volume":"22","author":"Xu F","year":"2022","journal-title":"BMC Complement Med Ther"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1016\/j.sjbs.2021.06.031","article-title":"Neuroprotective effects of ononin against the aluminium chloride-induced Alzheimer\u2019s disease in rats","volume":"28","author":"Chen X","year":"2021","journal-title":"Saudi J Biol Sci"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.3390\/ijms24032899","article-title":"Inflammation and obesity: the pharmacological role of flavonoids in the zebrafish model","volume":"24","author":"Russo C","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"106112","DOI":"10.1016\/j.micpath.2023.106112","article-title":"Rhoifolin protects cecal ligation and puncture induced sepsis mice model by regulating inflammatory pathway","volume":"180","author":"Wen S","year":"2023","journal-title":"Microb Pathog"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa H","year":"1979","journal-title":"Anal Biochem"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra HP","year":"1972","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0076-6879(02)47011-5","article-title":"Estimation of individual types of glutathione peroxidases","volume":"347","author":"Brigelius-Floh\u00e9 R","year":"2002","journal-title":"Methods Enzymol"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00942-19","article-title":"Can the cecal ligation and puncture model be repurposed to better inform therapy in human sepsis?","volume":"88","author":"Alverdy JC","year":"2020","journal-title":"Infect Immun"},{"issue":"Suppl.1","key":"ref18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40635-020-00350-y","article-title":"Comparison of direct and indirect models of early induced acute lung injury","volume":"8","author":"Chimenti L","year":"2020","journal-title":"Intensive Care Med Exp"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1038\/s41591-022-01894-0","article-title":"Prospective, multi-site study of patient outcomes after implementation of the TREWS machine learning-based early warning system for sepsis","volume":"28","author":"Adams R","year":"2022","journal-title":"Nat Med"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s44231-022-00019-y","article-title":"Effect of fluid resuscitation strategies for obese patients with sepsis and septic shock: a systematic review","volume":"3","author":"Zhang Y","year":"2023","journal-title":"Intensive Care Res"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/SHK.0000000000002096","article-title":"A modified surgical sepsis model satisfying sepsis-3 and having high consistency of mortality","volume":"59","author":"Wang J","year":"2023","journal-title":"Shock"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"7159","DOI":"10.2147\/IJGM.S328419","article-title":"Multiple organ dysfunction syndrome caused by sepsis: risk factor analysis","volume":"14","author":"Sun GD","year":"2021","journal-title":"Int J Gen Med"},{"issue":"4","key":"ref23","first-page":"285","article-title":"The relationship between lipid profile and severity of liver damage in cirrhotic patients","volume":"10","author":"Ghadir MR","year":"2010","journal-title":"Hepat Mon"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3109\/08830185.2014.889129","article-title":"The role of the liver in sepsis","volume":"33","author":"Yan J","year":"2014","journal-title":"Int Rev Immunol"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.immuni.2013.10.010","article-title":"The spleen in local and systemic regulation of immunity","volume":"39","author":"Bronte V","year":"2013","journal-title":"Immunity"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/joim.12104","article-title":"HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6C(high) inflammatory monocytes in murine sepsis survivors","volume":"274","author":"Vald\u00e9s-Ferrer SI","year":"2013","journal-title":"J Intern Med"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.59566\/IJBS.2008.4089","article-title":"Free radicals, antioxidants in disease and health","volume":"4","author":"Pham-Huy LA","year":"2008","journal-title":"Int J Biomed Sci"},{"issue":"Pt B","key":"ref28","doi-asserted-by":"crossref","first-page":"107087","DOI":"10.1016\/j.intimp.2020.107087","article-title":"Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets","volume":"89","author":"Kumar V.","year":"2020","journal-title":"Int Immunopharmacol"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502025000100255&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:17:17Z","timestamp":1762859837000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502025000100255&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":28,"alternative-id":["S0102-86502025000100255"],"URL":"https:\/\/doi.org\/10.1590\/acb407825","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e407825"}}