{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T14:59:38Z","timestamp":1763477978669,"version":"3.45.0"},"reference-count":46,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To examine the cardioprotective effects of myrrhone against isoproterenol (ISO)-induced myocardial injury in rats.  Methods: Myocardial injury was induced in the rats through subcutaneous administration of ISO (85 mg\/kg). The body weight, heart weight, electrocardiogram (ECG), cardiac, antioxidant, electrolyte, membrane-bound enzymes, antioxidant, cytokines, and inflammatory parameters were estimated. The mRNA expression of inflammatory parameters was estimated in the cardiac tissue.  Results: Myrrhone treatment significantly (p &lt; 0.001) altered ECG parameters, body weight, heart weight, and heart weight\/body weight ratio. Myrrhone significantly (p &lt; 0.001) improved the level of 5-hydroxytryptamine (5-HT) and suppressed the level of cardiac parameters like creatine kinase-MB, creatine kinase, lactate dehydrogenase, cardiac troponin I, and cardiac troponin T. It also suppressed the level of hepatic parameters such as aspartate aminotransferase, and alanine transaminase; altered the electrolyte, membrane-bound enzymes, and antioxidant parameters. Myrrhone treatment significantly (p &lt; 0.001) altered the level of cytokines such as tumor necrosis factor-\u03b1 (TNF-\u03b1), interleukin (IL)-10, IL-1\u03b2, IL-17, and IL-6; inflammatory parameters like cyclooxygenase-2, prostaglandin, inducible nitric oxide synthetase, nuclear factor kappa-light-chain enhancer of activated B cells; matrix metalloproteinases such as 2, and 9; apoptosis parameters viz., Bcl-2-associated X protein (Bax), B-cell lymphoma 2 protein (Bcl-2), and caspase-3 parameters. Myrrhone treatment significantly (p &lt; 0.001) altered the mRNA expression IL-6, IL-1\u03b2, IL-10, TNF-\u03b1, Bcl-2, caspase-3, Bax, and caspase-9.  Conclusion: Myrrhone exhibited the cardioprotective effect against ISO-induced myocardial injury in rats via alteration of kappa-light-chain enhancer of activated B cells (NF-\u03baB) and Bax\/Bcl-2\/caspase-3 signaling.<\/jats:p>","DOI":"10.1590\/acb408225","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T14:56:03Z","timestamp":1763477763000},"source":"Crossref","is-referenced-by-count":0,"title":["Myrrhone exert cardioprotective effect against isoproterenol-induced myocardial injury in rats via alteration of NF-\u03baB and Bax\/Bcl-2\/caspase-3 signaling"],"prefix":"10.1590","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0921-9336","authenticated-orcid":false,"given":"Lin","family":"Lin","sequence":"first","affiliation":[{"name":"Xi\u2019an No. 5 Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0030-2716","authenticated-orcid":false,"given":"Jinhua","family":"Shao","sequence":"additional","affiliation":[{"name":"Xi\u2019an No. 5 Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"55","key":"ref1","doi-asserted-by":"crossref","first-page":"34473","DOI":"10.1039\/C7RA00743D","article-title":"Protective effect and mechanistic evaluation of linalool against acute myocardial ischemia and reperfusion injury in rats","volume":"7","author":"Zheng XH","year":"2017","journal-title":"RSC Adv"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"100190","DOI":"10.1016\/j.phyplu.2021.100190","article-title":"Cardioprotective effect of hydroalcoholic extract of Brazilian red propolis against isoproterenol-induced myocardial infarction in 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