{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:02:33Z","timestamp":1777968153155,"version":"3.51.4"},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2017\/05585-8"],"award-info":[{"award-number":["2017\/05585-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To verify the differences in the reversibility of renal function and damage in rats of different ages with unilateral ureteral obstruction (UUO).  Methods: Sixty rats were divided into three different groups, newborns, young, and adults. Twenty-one were sham operated. After UUO, the animals were subdivided into four groups: obstruction (two weeks and sacrifice O2); UUO two weeks, obstruction release for two weeks and sacrifice (R2); UUO for four weeks and sacrifice (O4); and UUO for four weeks, obstruction release for two weeks and sacrifice (R4). Urine was collected for creatinine, urea, total protein, and albumin dosages, and kidneys for morphological studies.  Results: Younger rats presented more extensive destruction of renal parenchyma, with some remaining normal tissue healthier in comparison to older rats. The protein excretion by older rats was not different between the groups obstructed for different periods, albuminuria was progressively higher in rats obstructed for longer periods, and after relief of obstruction, there was no difference between newborn rats obstructed for different periods. The younger pyelostomized rats presented higher albumin excretion. Creatinine excretion was worsened in rats after obstruction.  Conclusion: Shorter obstruction periods lead to better prognosis, and younger rats showed better recovery after relief of obstruction than older ones.<\/jats:p>","DOI":"10.1590\/acb408325","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:16:12Z","timestamp":1762859772000},"source":"Crossref","is-referenced-by-count":1,"title":["Study of hydronephrosis and renal function reversibility on different development stages of rats that underwent unilateral ureteral obstruction, followed by its release through pyelostomy"],"prefix":"10.1590","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5481-032X","authenticated-orcid":false,"given":"Ana Cristina Aoun","family":"Tannuri","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-9185","authenticated-orcid":false,"given":"Victor Kenji Utino","family":"Kitahara","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7026-3717","authenticated-orcid":false,"given":"Alexandre Amatruda","family":"Marum","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0720-9256","authenticated-orcid":false,"given":"Bruno","family":"Mola","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9412-6661","authenticated-orcid":false,"given":"Daniel Felipe Marcelino","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4378-5237","authenticated-orcid":false,"given":"Lucas Menon","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8752-5624","authenticated-orcid":false,"given":"Vitor Ribeiro","family":"Paes","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2615-7730","authenticated-orcid":false,"given":"Katia Ramos Moreira","family":"Leite","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5853-5743","authenticated-orcid":false,"given":"Suellen","family":"Serafini","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5402-6455","authenticated-orcid":false,"given":"Josiane de Oliveira","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-3298","authenticated-orcid":false,"given":"Uenis","family":"Tannuri","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11934-015-0539-1","article-title":"Surgical approaches to pediatric ureteropelvic junction obstruction","volume":"16","author":"Tubre RW","year":"2015","journal-title":"Curr Urol Rep"},{"issue":"4","key":"ref2","first-page":"328","article-title":"Chronic renal insufficiency in children and adolescents: the 1996 annual report of NAPRTCS","volume":"12","author":"Fivush BA","year":"1998","journal-title":"North American Pediatric Renal Transplant Cooperative Study. Pediatr Nephrol"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s004670050132","article-title":"The 1994 annual report of the North American Pediatric Renal Transplant Cooperative Study","volume":"10","author":"Kohaut EC","year":"1996","journal-title":"Pediatr Nephrol"},{"issue":"4","key":"ref4","first-page":"328","article-title":"Chronic renal insufficiency in children and adolescents: the 1996 annual report of NAPRTCS","volume":"12","author":"Fivush BA","year":"1998","journal-title":"North American Pediatric Renal Transplant Cooperative Study. Pediatr Nephrol"},{"key":"ref5","series-title":"Kidney development. Methods in molecular biology","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/978-1-61779-851-1_33","volume-title":"Variable partial unilateral ureteral obstruction and its release in the neonatal and adult mouse","volume":"886","author":"Thornhill BA","year":"2012"},{"issue":"4 Pt 2","key":"ref6","first-page":"F854","article-title":"In situ localization of renin and its mRNA in neonatal ureteral obstruction","volume":"258","author":"el-Dahr SS","year":"1990","journal-title":"Am J Physiol"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S0022-5347(01)66407-3","article-title":"Arrested development of the neonatal kidney following chronic ureteral obstruction","volume":"155","author":"Chung KH","year":"1996","journal-title":"J Urol"},{"issue":"1","key":"ref8","first-page":"80","article-title":"Description of a disposable individual-mouse urine collection apparatus","volume":"31","author":"Smith CR","year":"1981","journal-title":"Lab Anim Sci"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1258\/0023677041958945","article-title":"Experimental animal urine collection: a review","volume":"38","author":"Kurien BT","year":"2004","journal-title":"Lab Anim"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"9314","DOI":"10.1038\/srep09314","article-title":"Urinary candidate biomarker discovery in a rat unilateral ureteral obstruction model","volume":"5","author":"Yuan Y","year":"2015","journal-title":"Sci Rep"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/S0022-5347(01)62614-4","article-title":"Experimental partial unilateral ureter obstruction. I. Pressure flow relationship in a rat model with mild and severe acute ureter obstruction","volume":"160","author":"Wen JG","year":"1998","journal-title":"J Urol"},{"issue":"1&#8211;4","key":"ref12","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000363721","article-title":"Renal functional reserve and renal recovery after acute kidney injury","volume":"127","author":"Sharma A","year":"2014","journal-title":"Nephron Clin Pract"},{"issue":"3","key":"ref13","first-page":"341","article-title":"The influence of age on the response to renal parenchymal loss","volume":"51","author":"Aschinberg LC","year":"1978","journal-title":"Yale J Biol Med"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1046\/j.1523-1755.1999.055003793.x","article-title":"Recovery following relief of unilateral ureteral obstruction in the neonatal rat","volume":"55","author":"Chevalier RL","year":"1999","journal-title":"Kidney Int"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1046\/j.1523-1755.2002.00359.x","article-title":"Recovery from release of ureteral obstruction in the rat: Relationship to nephrogenesis","volume":"61","author":"Chevalier R","year":"2002","journal-title":"Kidney Int"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/labinvest.2013.90","article-title":"Urinary tract obstruction in the mouse: the kinetics of distal nephron injury","volume":"93","author":"Hiatt MJ","year":"2013","journal-title":"Lab Invest"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1523-1755.2005.00052.x","article-title":"Variable chronic partial ureteral obstruction in the neonatal rat: a new model of ureteropelvic junction obstruction","volume":"67","author":"Thornhill BA","year":"2005","journal-title":"Kidney Int"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"F1087","DOI":"10.1152\/ajprenal.00201.2003","article-title":"Early release of neonatal ureteral obstruction preserves renal function","volume":"286","author":"Shi Y","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"issue":"6 Pt 2","key":"ref19","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1097\/01.ju.0000144286.53562.95","article-title":"Pathophysiology of unilateral ureteral obstruction: studies from Charlottesville to New York","volume":"172","author":"Vaughan Jr ED","year":"2004","journal-title":"J Urol"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ki.2009.86","article-title":"Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy","volume":"75","author":"Chevalier RL","year":"2009","journal-title":"Kidney Int"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502025000100256&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:16:16Z","timestamp":1762859776000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502025000100256&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":20,"alternative-id":["S0102-86502025000100256"],"URL":"https:\/\/doi.org\/10.1590\/acb408325","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e408325"}}