{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:22:12Z","timestamp":1762860132364,"version":"build-2065373602"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To investigate the protective effect of trans-anethole in experimental traumatic brain injury (TBI) in mice.  Methods: Thirty-five adult mice were divided into five groups (control, TBI, TBI+A40, TBI+A80, and TBI+A160). No treatment was performed in the control group. The treated groups (TBI+A40, TBI+A80, and TBI+A160) received 40, 80 or 160 mg\/kg trans-anethole treatment, respectively. At the end of the experiment, the brains of the sacrificed animals were removed, and laboratory analyses were performed.  Results: Malondialdehyde (MDA) levels in brain tissue of TBI and TBI+A40 were significantly increased, while MDA levels of TBI+A80 and TBI were similar. TBI+A160 and control tissue MDA levels were similar (p &gt; 0.05), significantly different from TBI (p &lt; 0.01). Immunodensity analyses showed that there was a significant difference between the control and TBI in terms of Bax, caspase 3, tumor necrosis factor-\u03b1 (TNF-\u03b1) and interleukin- (IL)-1\u03b2 immunoexpression. TBI+A40 immunoexpression was similar to TBI (p &gt; 0.05), significantly different from the control groups (p &lt; 0.05). In TBI+A80 and TBI+A160, pro-apoptotic Bax and caspase 3, pro-inflammatory TNF-\u03b1 and IL-1\u03b2 levels were also significantly improved. Immunoexpression levels of TBI+A160 and control were similar (p &gt; 0.05).  Conclusion: in our study, trans-anethole treatment had a dose-dependent neuroprotective potential against trauma-induced neurodegeneration.<\/jats:p>","DOI":"10.1590\/acb408525","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:17:12Z","timestamp":1762859832000},"source":"Crossref","is-referenced-by-count":0,"title":["Dose-dependent protective profile of trans-anethole in experimental traumatic brain injury in mice via modulation of apoptotic and inflammatory protein expression, and oxidative stress"],"prefix":"10.1590","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9804-3992","authenticated-orcid":false,"given":"Aziz","family":"\u00c7evik","sequence":"first","affiliation":[{"name":"Dicle University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4895-0916","authenticated-orcid":false,"given":"Burak","family":"Atlas","sequence":"additional","affiliation":[{"name":"Dicle University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5854-8517","authenticated-orcid":false,"given":"Gamze","family":"Erdo\u011fan","sequence":"additional","affiliation":[{"name":"Dicle University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6445-876X","authenticated-orcid":false,"given":"Mehmet Salih","family":"Atama","sequence":"additional","affiliation":[{"name":"Genesis Private Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2727-1025","authenticated-orcid":false,"given":"Bar\u0131\u015f","family":"Altun","sequence":"additional","affiliation":[{"name":"Nusaybin State Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1444-3246","authenticated-orcid":false,"given":"Tevfik","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Dicle University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"Suppl.10","key":"ref1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1528-1157.44.s10.3.x","article-title":"The epidemiology of traumatic brain injury: a review","volume":"44","author":"Bruns Jr. J","year":"2003","journal-title":"Epilepsia"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3389\/fncel.2019.00528","article-title":"Traumatic brain injuries: pathophysiology and potential therapeutic targets","volume":"13","author":"Ng SY","year":"2019","journal-title":"Front Cell 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