{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T01:22:42Z","timestamp":1770427362621,"version":"3.49.0"},"reference-count":18,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2020\/03925-9"],"award-info":[{"award-number":["2020\/03925-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To evaluate the effects of direct and remote ischemic preconditioning and postconditioning on kidney ischemia\u2013reperfusion injury in young rats.  Methods: This study was divided into two experimental phases: preconditioning and postconditioning. In each phase, 78 rats were randomly assigned to four groups: control (CG), ischemia-reperfusion (IRG), direct ischemic pre\/postconditioning (DIPG), and remote ischemic pre\/postconditioning (RIPG). Animals were euthanized at 0- or 24-hours post-procedure, and samples were collected for histological and biochemical analyses.  Results: The sum of the histological findings revealed no significant differences among the pre\/postconditioning groups. However, serum calcium levels were significantly higher in preconditioning, DIPG compared to the control group (p = 0.002), and in postconditioning, DIPG and RIPG compared to the control group (p = 0.028 and p = 0.005, respectively). In postconditioning, the chlorine levels were higher in IRG compared to the DIPG group (p = 0.029).  Conclusion: In our findings, ischemic preconditioning and ischemic postconditioning no provided significant protection of renal tissue.<\/jats:p>","DOI":"10.1590\/acb410726","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T13:00:32Z","timestamp":1770382832000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparison of the effects of direct and remote ischemic post and preconditioning in the kidney of young rats: histological and laboratory evaluation"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9386-8591","authenticated-orcid":false,"given":"Arthur Henrique de Almeida","family":"Oliveira","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-3476","authenticated-orcid":false,"given":"Daniel Meirelles de","family":"Paula","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5853-5743","authenticated-orcid":false,"given":"Suellen","family":"Serafini","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-3298","authenticated-orcid":false,"given":"Uenis","family":"Tannuri","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5481-032X","authenticated-orcid":false,"given":"Ana Cristina Aoun","family":"Tannuri","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1007\/s00467-021-05099-4","article-title":"Growth in children on kidney replacement therapy: a review of data from patient registries","volume":"36","author":"Bonthuis M","year":"2021","journal-title":"Pediatr Nephrol"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1053\/j.ackd.2017.09.009","article-title":"Special considerations in pediatric kidney transplantation","volume":"24","author":"Hebert SA","year":"2017","journal-title":"Adv Chronic Kidney Dis"},{"issue":"6","key":"ref3","first-page":"529","article-title":"Protective effect of remote ischemic per-conditioning in the ischemia and reperfusion-induced renal injury in rats","volume":"39","author":"Yamaki VN","year":"2012","journal-title":"Rev Col Bras Cir"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"11186","DOI":"10.34119\/bjhrv5n3-268","article-title":"Kidney transplantation and its relation with growth in the pediatric age group: a bibliographic review","volume":"5","author":"Faro BL","year":"2022","journal-title":"Braz J Health Rev"},{"issue":"3","key":"ref5","first-page":"462","article-title":"Topography of focal proximal tubular necrosis after ischemia with reflow in the rat kidney","volume":"122","author":"Shanley PF","year":"1986","journal-title":"Am J Pathol"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1681\/ASN.2019010068","article-title":"Tubular GM-CSF promotes late MCP-1\/CCR2-mediated fibrosis and inflammation after ischemia\/reperfusion injury","volume":"30","author":"Xu L","year":"2019","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1590\/S1676-24442002000400009","article-title":"Achados histol\u00f3gicos em 48 pacientes transplantados do f\u00edgado: bi\u00f3psias do enxerto p\u00f3s-reperfus\u00e3o (tempo zero) e de tr\u00eas a 15 dias p\u00f3s-transplante","volume":"38","author":"Castro AF","year":"2002","journal-title":"J Bras Patol Med Lab"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.transproceed.2006.01.014","article-title":"Renal transplantation in children","volume":"38","author":"S\u00f6zen H","year":"2006","journal-title":"Transplant Proc"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"8345","DOI":"10.3390\/ijms24098345","article-title":"Is renal ischemic preconditioning an alternative to ameliorate the short- and long-term consequences of acute kidney injury?","volume":"24","author":"Ortega-Trejo JA","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150863","article-title":"Preclinical evidence for the efficacy of ischemic postconditioning against renal ischemia-reperfusion injury, a systematic review and meta-analysis","volume":"11","author":"Jonker SJ","year":"2016","journal-title":"PLoS One"},{"issue":"6","key":"ref11","first-page":"586","article-title":"Preconditioning and postconditioning reduce hepatic ischemia-reperfusion injury in rats","volume":"8","author":"Zhang WX","year":"2009","journal-title":"Hepatobiliary Pancreat Dis Int"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032296","article-title":"Ischemic preconditioning in the animal kidney, a systematic review and meta-analysis","volume":"7","author":"Wever KE","year":"2012","journal-title":"PLoS One"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1097\/TP.0b013e318281b934","article-title":"Protection against renal ischemia-reperfusion injury by ischemic postconditioning","volume":"95","author":"van den Akker EK","year":"2013","journal-title":"Transplantation"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/1074248417702480","article-title":"Remote ischemic conditioning and renal protection","volume":"22","author":"Giannopoulos G","year":"2017","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris T","year":"2012","journal-title":"Int Rev Cell Mol Biol"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/08860229909066978","article-title":"Ischemic preconditioning attenuates functional, metabolic, and morphologic injury from ischemic acute renal failure in the rat","volume":"21","author":"Cochrane J","year":"1999","journal-title":"Ren Fail"},{"key":"ref17","doi-asserted-by":"crossref","DOI":"10.1038\/srep44430","article-title":"The age-associated loss of ischemic preconditioning in the kidney is accompanied by mitochondrial dysfunction, increased protein acetylation and decreased autophagy","volume":"7","author":"Jankauskas SS","year":"2017","journal-title":"Sci Rep"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2174\/1874375700903010018","article-title":"Postconditioning does not improve renal function or attenuate tubular damage in ischemia\/reperfusion-induced acute kidney injury in mice","volume":"3","author":"Zhuang S","year":"2009","journal-title":"Open Pathol J"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502026000100604&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T13:00:36Z","timestamp":1770382836000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502026000100604&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":18,"alternative-id":["S0102-86502026000100604"],"URL":"https:\/\/doi.org\/10.1590\/acb410726","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e410726"}}