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Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To evaluate the renal morphology after isolated and combined administration of dutasteride and tamsulosin in rats.  Methods: Forty male rats were divided in groups: control group; D, receiving 0.5 mg\/kg\/day of dutasteride; T, receiving 0.4 mg\/kg\/day of tamsulosin; and D+T, receiving both dutasteride and tamsulosin. The drugs were given by gavage for 40 days. The animals were killed, and kidneys were collected for stereological analyses of kidney volume, cortical volume, volumetric density of glomeruli, mean glomerular volume, and number of glomeruli per kidney. Data was compared by analysis of variance followed by Bonferroni\u2019s post-hoc test.  Results: Kidney weight, kidney volume, cortical volume, and glomerular volumetric density were reduced in all treated groups, in comparison to control group. The mean glomerular volume was reduced in groups D and D+T, in comparison to control rats, but in group T this parameter was not altered. Finally, the number of glomeruli per kidney was reduced by 37.9% in the group D, by 25.7% in group T, and by 33.07% in group D+T, in comparison to control group.  Conclusion: The use of dutasteride and tamsulosin (isolated or in combination) promoted kidney damage with nephron losses in the rodent model. Animals that received dutasteride showed more severe renal modifications than those that received tamsulosin and combined therapy.<\/jats:p>","DOI":"10.1590\/acb410826","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:15:09Z","timestamp":1773054909000},"source":"Crossref","is-referenced-by-count":0,"title":["The effects of dutasteride and tamsulosin, alone or in association, in the kidney morphology: experimental study in rats"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2722-9759","authenticated-orcid":false,"given":"Marcello Henrique Araujo da","family":"Silva","sequence":"first","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9532-2182","authenticated-orcid":false,"given":"Simone Gomes","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7284-0362","authenticated-orcid":false,"given":"Bianca Martins","family":"Greg\u00f3rio","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9087-9319","authenticated-orcid":false,"given":"Francisco Jos\u00e9","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3456-5029","authenticated-orcid":false,"given":"Diogo Benchimol de","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ucl.2016.04.001","article-title":"The epidemiology of benign prostatic hyperplasia associated with lower urinary tract symptoms: prevalence and incident rates","volume":"43","author":"Egan KB","year":"2016","journal-title":"Urol Clin North Am"},{"key":"ref2","first-page":"1","article-title":"Current evidence for the involvement of sex steroid receptors and sex hormones in benign prostatic hyperplasia","volume":"11","author":"Da Silva MHA","year":"2019","journal-title":"Res Rep Urol"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.eururo.2014.12.038","article-title":"EAU Guidelines on the assessment of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction","volume":"67","author":"Gratzke C","year":"2015","journal-title":"Eur Urol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/smrj.3","article-title":"Side effects of 5-alpha reductase inhibitors: a comprehensive review","volume":"1","author":"Trost L","year":"2013","journal-title":"Sex Med Rev"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4103\/aja.aja_28_18","article-title":"The corpus cavernosum after treatment with dutasteride or finasteride: A histomorphometric study in a benign prostatic hyperplasia rodent model","volume":"20","author":"Da Silva MHA","year":"2018","journal-title":"Asian J Androl"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1080\/13685538.2019.1653839","article-title":"Effects of the dutasteride and sildenafil association in the penis of a benign prostatic hyperplasia animal model","volume":"23","author":"Da Silva MHA","year":"2020","journal-title":"Aging Male"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1111\/j.1743-6109.2011.02425.x","article-title":"The effects of chronic 5-alpha-reductase inhibitor (dutasteride) treatment on rat erectile function","volume":"8","author":"Pinsky MR","year":"2011","journal-title":"J Sex Med"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"240","DOI":"10.5534\/wjmh.180082","article-title":"Persistent erectile dysfunction after discontinuation of 5-alpha reductase inhibitor therapy in rats depending on the duration of treatment","volume":"37","author":"Sung HH","year":"2019","journal-title":"World J Mens Health"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.3390\/ijerph16101726","article-title":"Finasteride-induced inhibition of 5\u03b1-reductase type 2 could lead to kidney damage-animal, experimental study","volume":"16","author":"Baig MS","year":"2019","journal-title":"Int J Environ Res Public Health"},{"issue":"7","key":"ref10","article-title":"Does treatment with dutasteride or finasteride has impact on renal morphology? 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