{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T19:47:21Z","timestamp":1776282441838,"version":"3.50.1"},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["303915\/2023-4"],"award-info":[{"award-number":["303915\/2023-4"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["401672\/2023-9"],"award-info":[{"award-number":["401672\/2023-9"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["406264\/2022-8"],"award-info":[{"award-number":["406264\/2022-8"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["303915\/2023-4"],"award-info":[{"award-number":["303915\/2023-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["401672\/2023-9"],"award-info":[{"award-number":["401672\/2023-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["406264\/2022-8"],"award-info":[{"award-number":["406264\/2022-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: This study aimed to evaluate the effect of oral administration of a hydroethanolic extract of Commiphora leptophloeos leaves (CLF) on the progression of 5-fluorouracil (5-FU)-induced intestinal mucositis.  Methods: Female Swiss mice were orally administered CLF at doses of 10, 100, or 300 mg\/kg, or saline (negative control, NC), starting 30 minutes before intraperitoneal injection of 5-FU. A positive control (PC) group received 5-FU without CLF treatment. Treatment continued until euthanasia, three days after 5-FU injection. Body weight was monitored throughout the experiment. On day 4, small intestine tissue samples were collected for histopathological analysis. Duodenal tissue was also assessed for Muc-2 immunostaining.  Results: In the CLF 10, 100 and 300 mg\/kg groups, the duodenum histopathological score was 1 (1\u20131.5) p &lt; 0.001, 1 (1\u20131.5) p &lt; 0.01; 1 (1\u20131.25) p &lt; 0.01, while the PC group score was 2 (2\u20132.75). Immunostaining analysis for Muc-2 revealed a score of 3 (3\u20133) in the CLF 10 group, compared to score 1.2 (0.8\u20131.6) in the PC group (p &lt; 0.001), indicating that CLF 10 increased Muc-2 expression.  Conclusion: The oral administration of a hydroethanolic extract of CLF protected the duodenal segment of Swiss mice from 5-FU-induced intestinal mucositis, likely by increasing mucin production.<\/jats:p>","DOI":"10.1590\/acb411526","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:19:37Z","timestamp":1776277177000},"source":"Crossref","is-referenced-by-count":0,"title":["The beneficial effects of leave extract of Commiphora leptophloeos on intestinal mucositis induced by 5-fluorouracil in mice"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6727-6816","authenticated-orcid":false,"given":"Amanda Silveira da","family":"Silva","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8774-9254","authenticated-orcid":false,"given":"Stephannie Jamyla de Ara\u00fajo","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5209-8239","authenticated-orcid":false,"given":"Susana Barbosa","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil; Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5832-3854","authenticated-orcid":false,"given":"Lucas Vinicius Souza de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4019-7050","authenticated-orcid":false,"given":"Rafaela Torres Dantas da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-8116","authenticated-orcid":false,"given":"Gerlane Coelho Bernardo","family":"Guerra","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2349-2354","authenticated-orcid":false,"given":"Raimundo Fernandes de","family":"Ara\u00fajo J\u00fanior","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil; Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4209-2984","authenticated-orcid":false,"given":"Nizyara Costa da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4196-4263","authenticated-orcid":false,"given":"Raphael Victor Silva","family":"Andrade","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9169-6562","authenticated-orcid":false,"given":"Gabrielle Marques de","family":"Paiva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2768-0793","authenticated-orcid":false,"given":"Silvana Maria Zucolotto","family":"Langassner","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2208-7808","authenticated-orcid":false,"given":"Renato","family":"Dantas-Medeiros","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5123-0741","authenticated-orcid":false,"given":"Rafaela Alcindo Silva de Sousa","family":"F\u00e9","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1394-6420","authenticated-orcid":false,"given":"Maria Laura de Souza","family":"Lima","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9264-4695","authenticated-orcid":false,"given":"Aurigena Antunes de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte,  Brazil; Universidade Federal do Rio Grande do Norte,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrc1074","article-title":"5-fluorouracil: mechanisms of action and clinical strategies","volume":"3","author":"Longley DB","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"154791","DOI":"10.1016\/j.cyto.2019.154791","article-title":"Modulation of 5-fluorouracil activation of toll-like\/MyD88\/NF-\u03baB\/MAPK pathway by Saccharomyces boulardii CNCM I-745 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