{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T19:50:06Z","timestamp":1776282606128,"version":"3.50.1"},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To evaluate the effects of maternal arginine-enriched diet during lactation, following gestational undernutrition, on offspring growth and wound healing.  Methods: Pregnant Wistar rats were divided into two groups during gestation: control (C; ad libitum diet) and undernourished (Und; 60% of control diet). After delivery, the undernourished mothers were reassigned to two subgroups: ad libitum + Impact\u00ae (Arg) and ad libitum + Nutren\u00ae (Hh). Evaluated parameters included offspring anthropometric measurements, serum albumin, tensile strength, and collagen morphometry at the surgical wound. Statistical analyses included analysis of variance (ANOVA) and Tukey\u2019s, Student\u2019s t-test, and Fisher\u2019s test.  Results: Maternal immunonutrition during lactation promoted recovery of offspring weight (C = 29.21 \u00b1 2.86 g; Arg = 36.08 \u00b1 5.38 g; p = 0.0009) and body length (C = 9.87 \u00b1 0.32 cm; Arg = 10.91 \u00b1 0.73 cm; p = 0.0008), shifting values from significantly lower at birth to higher than controls by weaning. Offspring healing parameters showed no significant differences compared with controls.  Conclusion: An arginine-enriched diet provided to lactating rats malnourished during gestation significantly improved offspring anthropometric growth and supported wound healing following surgery at weaning.<\/jats:p>","DOI":"10.1590\/acb411626","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:23:44Z","timestamp":1776277424000},"source":"Crossref","is-referenced-by-count":0,"title":["Effects of maternal arginine supplementation during lactation on offspring growth and wound healing in an experimental rat model of intrauterine malnutrition"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0417-859X","authenticated-orcid":false,"given":"Ayrton Alves","family":"Aranha Junior","sequence":"first","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil; Hospital Pequeno Pr\u00edncipe,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6377-8870","authenticated-orcid":false,"given":"Jorge Eduardo Fouto","family":"Matias","sequence":"additional","affiliation":[{"name":"Hospital Pequeno Pr\u00edncipe,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2504-6318","authenticated-orcid":false,"given":"Djanira Aparecida da Luz","family":"Veronez","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0310-7164","authenticated-orcid":false,"given":"Lucia de","family":"Noronha","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5329-3235","authenticated-orcid":false,"given":"Jo\u00e3o Carlos","family":"Repka","sequence":"additional","affiliation":[{"name":"Hospital Angelina Caron,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5121-2636","authenticated-orcid":false,"given":"Rafaella Toledo","family":"Aranha","sequence":"additional","affiliation":[{"name":"Universidade Positivo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-8380","authenticated-orcid":false,"given":"Ant\u00f4nio Carlos Ligocki","family":"Campos","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"suppl.1","key":"ref1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1365-3016.2012.01279.x","article-title":"Global policy and programme guidance on maternal nutrition: what exists, the mechanisms for providing it, and how to improve them?","volume":"26","author":"Shrimpton R","year":"2012","journal-title":"Paediatr Perinat Epidemiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"111565","DOI":"10.1016\/j.nut.2021.111565","article-title":"Determinants of malnutrition among children: A systematic review","volume":"96","author":"Katoch OR","year":"2022","journal-title":"Nutrition"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1186\/s12887-023-04419-x","article-title":"The prevalence of malnutrition among critically ill children: a systematic review and meta-analysis","volume":"23","author":"Abera EG","year":"2023","journal-title":"BMC Pediatr"},{"issue":"6101","key":"ref4","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1126\/science.1224616","article-title":"Fetal and early childhood undernutrition, mortality, and lifelong health","volume":"337","author":"Lutter CK","year":"2012","journal-title":"Science"},{"issue":"Suppl.3","key":"ref5","first-page":"17","article-title":"Adverse effects of nutritional programming during prenatal and early postnatal life, some aspects of regulation and potential prevention and treatments","volume":"60","author":"Guilloteau P","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1136\/bmj.303.6809.1019","article-title":"Fetal and infant growth and impaired glucose tolerance at age 64","volume":"303","author":"Hales CN","year":"1991","journal-title":"BMJ"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/BF00400248","article-title":"Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis","volume":"35","author":"Hales CN","year":"1992","journal-title":"Diabetologia"},{"issue":"5","key":"ref8","first-page":"593","article-title":"Maternal nutrition: effects on health in the next generation","volume":"130","author":"Fall C","year":"2009","journal-title":"Indian J Med Res"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/BF00399095","article-title":"Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidemia (syndrome X): relation to reduced fetal growth","volume":"36","author":"Barker DJ","year":"1993","journal-title":"Diabetologia"},{"issue":"21","key":"ref10","doi-asserted-by":"crossref","first-page":"7982","DOI":"10.3390\/ijerph17217982","article-title":"Maternal and early-life nutrition and health","volume":"17","author":"Huang LT","year":"2020","journal-title":"Int J Environ Res Public Health"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000514884","article-title":"Enviromental exposure during pregnancy: influence on prenatal development and early life: a comprehensive review","volume":"48","author":"Gomez-Roig MD","year":"2021","journal-title":"Fetal Diagn Ther"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.3390\/nu11071628","article-title":"Preconception and prenatal nutrition and neurodevelopmental disorders: a systematic review and meta-analysis","volume":"11","author":"Li M","year":"2019","journal-title":"Nutrients"},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/14767050902874105","article-title":"Early undernutrition attenuates the inflammatory response in adult rat offspring","volume":"22","author":"Desai M","year":"2009","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.22203\/eCM.v022a24","article-title":"Animal models of maternal nutrition and altered offspring bone structure \u2013 bone development across the lifecourse","volume":"22","author":"Lanham AS","year":"2011","journal-title":"Eur Cell Mater"},{"issue":"Suppl.6","key":"ref15","doi-asserted-by":"crossref","first-page":"S1824","DOI":"10.3945\/ajcn.110.000729","article-title":"Maternal malnutrition programs the endocrine pancreas in progeny","volume":"94","author":"Reusens B","year":"2011","journal-title":"Am J Clin Nutr"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.3390\/nu14091766","article-title":"Nutrition during pregnancy and lactation: epigenetics effects on infants\u2019 immune system in food allergy","volume":"14","author":"Costanzo MD","year":"2022","journal-title":"Nutrients"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/0148607104028004241","article-title":"In utero malnutrition influences wound healing of newborn rats as measured by tensile strength and collagen deposition","volume":"28","author":"Coelho-Lemos ICM","year":"2004","journal-title":"J Parenter Enteral Nutr"},{"issue":"3","key":"ref18","first-page":"281","article-title":"Assessment and nutritional aspects of wound healing","volume":"11","author":"Campos ACL","year":"2008","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.clindermatol.2021.10.002","article-title":"Nutrition and cutaneous wound healing","volume":"40","author":"Grada A","year":"2022","journal-title":"Clin Dermatol"},{"issue":"Suppl.5","key":"ref20","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.12968\/jowc.2022.31.Sup5.S14","article-title":"The role of macronutrients and micronutrients in wound healing: a narrative review","volume":"31","author":"Penny H","year":"2022","journal-title":"J Wound Care"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.3390\/nu13082498","article-title":"The effect of amino acids on wound healing: a systematic review and meta-analysis on arginine and glutamine","volume":"13","author":"Arribas-Lopez E","year":"2021","journal-title":"Nutrients"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.clnesp.2024.10.155","article-title":"Nutritional requirements in pregnancy and lactation","volume":"64","author":"Talebi S","year":"2024","journal-title":"Clin Nutr ESPEN"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1017\/S1368980012003576","article-title":"Impact of folic acid fortification of flour on neural tube defects: a systematic review","volume":"16","author":"Castillo-Lancellotti C","year":"2013","journal-title":"Public Health Nutr"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1136\/archdischild-2024-328115","article-title":"Blood folate level needed for fully effective fortification in the prevention of neural tube defects","volume":"110","author":"Wald NJ","year":"2025","journal-title":"Arch Dis Child"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"101617","DOI":"10.1016\/j.pmedr.2021.101617","article-title":"Maternal folic acid and multivitamin supplementation: International clinical evidence with considerations for the prevention of folate-sensitive birth defects","volume":"24","author":"Wilson RD","year":"2021","journal-title":"Prev Med Rep"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/14767050410001725280","article-title":"Ultrasound evaluation of intrauterine growth restriction therapy by a nitric oxide donor (L-arginine)","volume":"15","author":"Sieroszewski P","year":"2004","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijgo.2004.09.017","article-title":"L-arginine treatment for asymmetric fetal growth restriction","volume":"88","author":"Xiao XM","year":"2005","journal-title":"Int J Gynaecol Obstet"},{"issue":"9","key":"ref28","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1093\/jn\/134.9.2169","article-title":"Maternal nutrition and fetal development","volume":"134","author":"Wu G","year":"2004","journal-title":"J Nutr"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/jpn.12679","article-title":"Arginine for gestating sows and foetal development; a systematic review","volume":"102","author":"Palencia JYP","year":"2018","journal-title":"J Anim Physiol Anim Nutr"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/jpn.14031","article-title":"L-Arginine supplementation for pregnant and lactating sows may improve the performance of piglets: a systematic review","volume":"109","author":"Cruz FL","year":"2025","journal-title":"J Anim Physiol Anim Nutr (Berl)"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2527\/jas.2007-0371","article-title":"Effects of dietary arginine supplementation during gestation and lactation on the performance of lactating primiparous sows and nursing piglets","volume":"86","author":"Mateo RD","year":"2008","journal-title":"J Anim Sci"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502026000100610&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T19:01:09Z","timestamp":1776279669000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502026000100610&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":31,"alternative-id":["S0102-86502026000100610"],"URL":"https:\/\/doi.org\/10.1590\/acb411626","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e411626"}}