{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:09:52Z","timestamp":1778501392681,"version":"3.51.4"},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Industry-University-Research Collaborative Technological Innovation Project of Yunnan Circular Agriculture Industry Research Institute of Pu\u2019er University","award":["2025PEUXJ03"],"award-info":[{"award-number":["2025PEUXJ03"]}]},{"name":"Industry-University-Research Collaborative Technological Innovation Project of Yunnan Circular Agriculture Industry Research Institute of Pu\u2019er University","award":["00100110"],"award-info":[{"award-number":["00100110"]}]},{"name":"Higher Education of Pu\u2019er University","award":["2025PEUXJ03"],"award-info":[{"award-number":["2025PEUXJ03"]}]},{"name":"Higher Education of Pu\u2019er University","award":["00100110"],"award-info":[{"award-number":["00100110"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To investigate the effect and mechanism of Portulaca oleracea L. (POL) extract on acetic acid and alloantigen-induced chronic ulcerative colitis in rats.  Methods: Ulcerative colitis was induced in rats by sensitization with rabbit colon antigen and acetic acid. Rats received oral sulfasalazine, intestine-quieting tablet, or POL (high, medium, or low dose) for 14 days. Disease activity index (DAI), colonic mucosal damage index (CMDI), and histological score (HS) were assessed. Serum levels of interleukin (IL)-4, IL-8, IL-17, C-reactive protein (CRP), immunoglobulin G (IgG), and interferon-\u03b3 (IFN-\u03b3); colonic levels of myeloperoxidase (MPO), epidermal growth factor (EGF), and tumor necrosis factor (TNF)-\u03b1; serum hemolysin (by immunoturbidimetry); splenic T lymphocyte subsets (by flow cytometry); and serum IgG, IgM, IgA, C3, and C4 were measured.  Results: Compared with the model group, POL significantly reduced DAI, CMDI, and HS scores in a dose-dependent manner\u2014most markedly in the high-dose group (p &lt; 0.01). POL also significantly decreased serum IL-8, IL-17, CRP, IFN-\u03b3, and IgG, and colonic TNF-\u03b1 and MPO (p &lt; 0.05 or p &lt; 0.01), while increasing serum IL-4 and colonic EGF (p &lt; 0.01). All POL dosage groups significantly increased hemolysin, IgM, and CD4+CD25+\/CD4+ levels in rats (p &lt; 0.05 or p &lt; 0.01), while decreasing serum IgG, IgA, complement C3\/C4, CD4+\/CD8+, and IL-17+ CD4+ (p &lt; 0.05 or p &lt; 0.01).  Conclusion: The POL extract exerts therapeutic effects in chronic ulcerative colitis rats, likely by downregulating pro-inflammatory mediators\u2014including IL-8, IL-17, CRP, IFN-\u03b3, TNF-\u03b1, and MPO\u2014, as well as serum IgG, IgA, C3\/C4, CD4+\/CD8+, and IL-17+ CD4+; and by upregulating anti-inflammatory\/repair factors\u2014including IL-4, EGF, lysozyme, IgM, and CD4+CD25+\/CD4+. These findings support the clinical potential of POL for ulcerative colitis treatment.<\/jats:p>","DOI":"10.1590\/acb412126","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:29:05Z","timestamp":1778498945000},"source":"Crossref","is-referenced-by-count":0,"title":["Study on the effect of Portulaca oleracea L. extract on chronic ulcerative colitis in rats induced by allogeneic antigen and acetic acid"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3877-7820","authenticated-orcid":false,"given":"Yan","family":"Wu","sequence":"first","affiliation":[{"name":"Zhejiang Chinese Medical University,  China; Lishui Second People\u2019s Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3902-8857","authenticated-orcid":false,"given":"Fang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Pu\u2019er University,  China; Pu\u2019er University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8075-523X","authenticated-orcid":false,"given":"Juan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Pu\u2019er University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9181-2615","authenticated-orcid":false,"given":"Rong-Yao","family":"Ruan","sequence":"additional","affiliation":[{"name":"Qingyuan County Maternal and Child Health and Family Planning Service Center,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9708-9897","authenticated-orcid":false,"given":"Fei-Yan","family":"Wu","sequence":"additional","affiliation":[{"name":"Lishui Second People\u2019s Hospital,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-1080","authenticated-orcid":false,"given":"Yusheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Pu\u2019er University,  China; Pu\u2019er University,  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3389\/fimmu.2019.00486","article-title":"Gab2 and Gab3 redundantly suppress colitis by modulating macrophage and CD8+ T-Cell activation","volume":"10","author":"Wang Z","year":"2019","journal-title":"Front Immunol"},{"issue":"36","key":"ref2","doi-asserted-by":"crossref","first-page":"8234","DOI":"10.3748\/wjg.v22.i36.8234","article-title":"Diagnosis of colonic amebiasis and coexisting signet-ring cell carcinoma in intestinal biopsy","volume":"22","author":"Grosse A","year":"2016","journal-title":"World J Gastroenterol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"16677","DOI":"10.1038\/s41598-024-66940-y","article-title":"Inflammatory bowel disease and risk for hemorrhoids: a Mendelian randomization analysis","volume":"14","author":"Wang H","year":"2024","journal-title":"Sci Rep"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/BOR.0000000000001017","article-title":"Sacroiliitis in inflammatory bowel disease","volume":"36","author":"Malik F","year":"2024","journal-title":"Curr Opin Rheumatol"},{"issue":"46","key":"ref5","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.3748\/wjg.v30.i46.4904","article-title":"Real-world experience and long-term outcomes of a mandatory non-medical switch of adalimumab originator to biosimilars in inflammatory bowel disease","volume":"30","author":"Kiow JLC","year":"2024","journal-title":"World J Gastroenterol"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cgh.2024.07.033","article-title":"Comparative efficacy of biologics and small molecule in ulcerative colitis: a systematic review and network meta-analysis","volume":"23","author":"Shehab M","year":"2025","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1111\/jvim.15761","article-title":"Evaluation of novel serological markers and autoantibodies in dogs with inflammatory bowel disease","volume":"34","author":"Estruch JJ","year":"2020","journal-title":"J Vet Intern Med"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","DOI":"10.1038\/ctg.2014.4","article-title":"Propionyl-L-Carnitine is efficacious in ulcerative colitis through its action on the immune function and microvasculature","volume":"5","author":"Scioli MG","year":"2014","journal-title":"Clin Transl Gastroenterol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"924178","DOI":"10.3389\/fimmu.2022.924178","article-title":"Moringa oleifera Lam. 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