{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:10:33Z","timestamp":1778501433782,"version":"3.51.4"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To investigate the biochemical and histopathological efficacy of agmatine as a protective agent in experimental rat contrast-induced nephropathy (CIN) model.  Methods: Twenty-eight male Sprague Dawley rats were randomized into four groups: sham (no intervention), contrast agent (single dose 10 mL\/kg iohexol iv), contrast agent + agmatine (single dose 10 mL\/kg iohexol iv + 20 mg\/kg po agmatine three days) and contrast agent + placebo (single dose 10 mL\/kg iohexol iv + 1 mL of 0.9% saline ip). Biochemical and histopathological evaluations were accomplished on the fourth day, including measurements of cystatin-C, malondialdehyde (MDA), glutathione peroxidase (GPx), interleukin (IL)-1 \u03b2, superoxide dismutase (SOD), and tumor necrosis factor (TNF)-\u03b1.  Results: The contrast agent group exhibited elevated cystatin-C, IL-1\u03b2, TNF-\u03b1, and MDA levels, with decreased SOD and GPx levels. The agmatine treatment group showed decrease in cystatin-C, IL-1\u03b2, TNF-\u03b1, and MDA, along with increased GPx and SOD levels. Histopathological evaluation revealed nephrotoxic effects in the contrast agent and placebo groups, whereas agmatine-treated rats displayed a significant reduction in tubular damage.  Conclusion: Agmatine administration along side contrast exposure demonstrated protective effects against CIN, evidenced by biochemical and histopathological improvements.<\/jats:p>","DOI":"10.1590\/acb412426","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:29:19Z","timestamp":1778498959000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of agmatine efficacy in contrast-induced nephropathy: experimental evidence in rat model"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3046-5784","authenticated-orcid":false,"given":"Murat","family":"Yeni\u00e7eri","sequence":"first","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-445X","authenticated-orcid":false,"given":"S\u00fcleyman","family":"Ba\u015f","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1977-5127","authenticated-orcid":false,"given":"Mustafa Can","family":"\u015eenoymak","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5050-531X","authenticated-orcid":false,"given":"Musa","family":"Salmano\u011flu","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7477-6640","authenticated-orcid":false,"given":"Alpaslan","family":"Tano\u011flu","sequence":"additional","affiliation":[{"name":"Bah\u00e7e\u015fehir University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pharmthera.2017.06.009","article-title":"Contrast-induced nephropathy: basic concepts, pathophysiological implications and prevention strategies","volume":"180","author":"Mamoulakis C","year":"2017","journal-title":"Pharmacol Ther"},{"issue":"6","key":"ref2","first-page":"826","article-title":"The incidence and associated risk factors of contrast-induced nephropathy after contrast-enhanced computed tomography in the emergency setting: a systematic review","volume":"12","author":"Ong MY","year":"2022","journal-title":"Life (Basel)"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"118379","DOI":"10.1016\/j.lfs.2020.118379","article-title":"Advances in the pathogenesis and prevention of contrast-induced nephropathy","volume":"259","author":"Zhang 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Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502026000100614&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:29:23Z","timestamp":1778498963000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502026000100614&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":26,"alternative-id":["S0102-86502026000100614"],"URL":"https:\/\/doi.org\/10.1590\/acb412426","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e412426"}}