{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:10:01Z","timestamp":1778501401695,"version":"3.51.4"},"reference-count":39,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: Glaucocalyxin A (GLA), a diterpenoid with antioxidative and anti-inflammatory properties, has shown vascular protective effects in preclinical models. This study aimed to evaluate whether GLA improves colonic anastomotic integrity following ischemia\u2013reperfusion (I\/R) injury.  Methods: Twenty-four female Sprague Dawley rats were randomized into three groups (n = 8): control + GLA, I\/R, and I\/R + GLA. I\/R was induced by 60-minute superior mesenteric artery occlusion and 60-minute reperfusion before end-to-end colonic anastomosis. GLA (10 mg\/kg) was administered intraperitoneally. On postoperative day 7, anastomotic bursting pressure, adhesion scores, hydroxyproline, oxidative stress markers (total oxidative status, total antioxidant capacity, ischemia-modified albumin), and histopathology were evaluated.  Results: The I\/R + GLA group demonstrated significantly higher bursting pressure compared with the I\/R group (126 versus 40 mmHg; p &lt; 0.005). Tissue TOS levels were significantly lower in the I\/R + GLA group compared with both other groups (p &lt; 0.005). No significant differences were found in hydroxyproline levels, IMA values, or histopathological healing scores.  Conclusion: GLA may support colonic anastomotic healing after I\/R injury by reducing oxidative stress and could serve as a potential protective agent against anastomotic compromise.<\/jats:p>","DOI":"10.1590\/acb412526","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:29:31Z","timestamp":1778498971000},"source":"Crossref","is-referenced-by-count":0,"title":["Glaucocalyxin A enhances colonic anastomotic healing after ischemia\u2013reperfusion: experimental findings"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4277-8446","authenticated-orcid":false,"given":"Mehmet","family":"Alg\u00fcl","sequence":"first","affiliation":[{"name":"Eskisehir Osmangazi University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0879-8988","authenticated-orcid":false,"given":"Bari\u015f Rafet","family":"Karaka\u015f","sequence":"additional","affiliation":[{"name":"Antalya Research and Training Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0726-3968","authenticated-orcid":false,"given":"O\u011fuzhan Fatih","family":"Ay","sequence":"additional","affiliation":[{"name":"Eskisehir Osmangazi University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7849-6531","authenticated-orcid":false,"given":"Sadika Halide","family":"Akba\u015f","sequence":"additional","affiliation":[{"name":"Akdeniz University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7246-7182","authenticated-orcid":false,"given":"Arzu","family":"Karaveli","sequence":"additional","affiliation":[{"name":"Antalya Research and Training Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7073-8786","authenticated-orcid":false,"given":"Kadir","family":"Balaban","sequence":"additional","affiliation":[{"name":"Antalya Training and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"5","key":"ref1","article-title":"Anastomotic leak after manual circular stapled left-sided bowel surgery: analysis of technology-, disease-, and patient-related factors","volume":"8","year":"2024","journal-title":"BJS Open"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","DOI":"10.1111\/codi.12125","article-title":"The economic impact of anastomotic leakage after anterior resections in E nglish NHS hospitals: Are we adequately remunerating them?","volume":"15","author":"Ashraf SQ","year":"2013","journal-title":"Colorectal 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