{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:02:39Z","timestamp":1784548959927,"version":"3.55.0"},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: Foreign body reaction is a tissue response in which excessive reactions may lead to complications such as chronic inflammation, mesh contraction, and impaired tissue integration. The present study aimed to evaluate the effects of steroid-impregnated polypropylene mesh on foreign body reaction and fibrosis in a rat abdominal wall model.  Methods: Forty adults female Wistar rats were randomly assigned into four groups (n = 10 each): polypropylene mesh in the acute period (group A), steroid-impregnated polypropylene mesh in the acute period (group AS), polypropylene mesh in the chronic period (group C), and steroid-impregnated polypropylene mesh in the chronic period (group CS). Standardized 1 \u00d7 1-cm meshes were implanted on the right rectus abdominis muscle. Acute groups were assessed at three days post-implantation, and chronic groups at nine weeks. Histopathological evaluation included grading of polymorphonuclear leukocyte infiltration, neovascularization, foreign-body giant cell reaction, muscle invasion, necrosis, and fibrosis. Immunohistochemical staining for CD15, CD68, CD3, and CD20 was performed to characterize inflammatory cell subtypes.  Results: The mean grading of polymorphonuclear leukocyte infiltration, neovascularization, foreign-body reaction, muscle invasion, and necrosis showed no difference among groups, in which fibrosis levels were significantly higher in group C and group CS compared to group A (p = 0.004, p = 0.004, respectively). The fibrosis levels were also elevated in group CS than in group AS (p = 0.001, p = 0.001, respectively).  Conclusion: Local corticosteroid impregnation of polypropylene mesh slightly attenuated early inflammatory responses but did not prevent chronic fibrosis.<\/jats:p>","DOI":"10.1590\/acb412926","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:16:15Z","timestamp":1784546175000},"source":"Crossref","is-referenced-by-count":0,"title":["The impact of steroid-impregnated polypropylene mesh on foreign body reaction in an experimental rat study"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3431-2072","authenticated-orcid":false,"given":"Hatice Yilmaz","family":"Dogru","sequence":"first","affiliation":[{"name":"Mersin City Training and Research Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7347-9003","authenticated-orcid":false,"given":"Akgul","family":"Arici","sequence":"additional","affiliation":[{"name":"Tokat Gaziosmanpa\u015fa University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10029-021-02396-7","article-title":"Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen","volume":"26","author":"Dievernich A","year":"2022","journal-title":"Hernia"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acsabm.1c00841","article-title":"Latest trends on the attenuation of systemic foreign body response and infectious complications of synthetic hernia meshes","volume":"5","author":"Xu D","year":"2022","journal-title":"ACS Appl Bio Mater"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.3390\/biomedicines10061294","article-title":"Ultra-fine polyethylene hernia meshes improve biocompatibility and reduce intraperitoneal adhesions in IPOM position in animal models","volume":"10","author":"Helmedag MJ","year":"2022","journal-title":"Biomedicines"},{"issue":"30","key":"ref4","doi-asserted-by":"crossref","first-page":"35456","DOI":"10.1021\/acsami.1c09089","article-title":"Synergistic anti-inflammatory coating \u201czipped up\u201d on polypropylene hernia mesh","volume":"13","author":"Huang L","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"022007","DOI":"10.1088\/1748-605X\/ac5574","article-title":"Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity","volume":"17","author":"Kyriakides TR","year":"2022","journal-title":"Biomed Mater"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s11255-014-0769-z","article-title":"The effect of pentoxifylline on penile cavernosal tissues in ischemic priapism-induced rat model","volume":"46","author":"Erdemir F","year":"2014","journal-title":"Int Urol Nephrol"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/jbm.a.33136","article-title":"Beneficial effects of hydrocortisone or spironolactone coating on foreign body response to mesh biomaterial in a mouse model","volume":"99A","author":"Brandt CJ","year":"2011","journal-title":"J Biomed Mater Res A"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/jbm.a.34671","article-title":"Polypropylene surgical mesh coated with extracellular matrix mitigates the host foreign body response","volume":"102","author":"Wolf MT","year":"2014","journal-title":"J Biomed Mater Res A"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s10029-024-02985-2","article-title":"Dexamethasone relieves the inflammatory response caused by inguinal hernia meshes through miR-155","volume":"28","author":"Li Y","year":"2024","journal-title":"Hernia"},{"issue":"9","key":"ref10","first-page":"1309","article-title":"The impact of corticosteroid administration at different time points on mucosal wound healing in rats: an experimental pilot in vivo study","volume":"11","author":"Weinberg E","year":"2022","journal-title":"Biology (Basel)"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1177\/03635465231153640","article-title":"Histological and biomechanical effects of local anesthetics and steroids on achilles tendon: a study in rats","volume":"51","author":"Kafa B","year":"2023","journal-title":"Am J Sports Med"},{"key":"ref12","article-title":"Pharmacological effects of triamcinolone associated with surgical glue on cutaneous wound healing in rats","volume":"39","author":"Doci RSA","year":"2024","journal-title":"Acta Cir Bras"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e24237","article-title":"Next generation meshes for hernia repair: Polypropylene meshes coated with antimicrobial benzalkonium chloride induced proliferative activity of fibroblasts","volume":"10","author":"Serrano-Aroca \u00c1","year":"2024","journal-title":"Heliyon"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1186\/s12951-024-02872-z","article-title":"Modification of transvaginal polypropylene mesh with co-axis electrospun nanofibrous membrane to alleviate complications following surgical implantation","volume":"22","author":"Guo T","year":"2024","journal-title":"J Nanobiotechnol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jss.2022.01.027","article-title":"Coated polypropylene mesh is associated with increased infection in abdominal wall reconstruction","volume":"275","author":"Ayuso SA","year":"2022","journal-title":"J Surg Res"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijmd1010001","article-title":"Advances in multifunctional hernia repair mesh to minimize post-surgical complications","volume":"1","author":"Wang Z","year":"2026","journal-title":"Int J Med Devices"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502026000100624&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:16:22Z","timestamp":1784546182000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502026000100624&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":16,"alternative-id":["S0102-86502026000100624"],"URL":"https:\/\/doi.org\/10.1590\/acb412926","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e412926"}}