{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:15:20Z","timestamp":1783682120725,"version":"3.55.0"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To compare the effects of captopril and losartan on inflammatory response, angiogenesis, and fibroblast activity during the early phase of wound healing in hypertensive rats.  Methods: Twenty-seven paraffin-embedded skin wound samples from hypertensive rats were analyzed: control group (n = 8), losartan-treated group (n = 9), and captopril-treated group (n = 10). Histological and immunohistochemical analyses were performed on postoperative day 4. Hematoxylin-eosin staining was used to evaluate general wound structure, and immunohistochemistry with anti-leukocyte common antigen, anti-CD34, and anti-smooth muscle actin was performed to assess inflammatory cells, angiogenesis, and fibroblast activity, respectively.  Results: No significant differences were observed in angiogenesis (p &gt; 0.05) or fibroblast number (p &gt; 0.05) between groups. However, the inflammatory reaction was significantly higher in captopril-treated (p = 0.0459) and losartan-treated (p = 0.0452) groups compared with the control group, with no significant difference between the two treated groups.  Conclusion: Neither captopril nor losartan influenced angiogenesis or fibroblast proliferation in the early healing phase. However, both drugs increased inflammatory cell infiltration.<\/jats:p>","DOI":"10.1590\/acb413126","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:41:59Z","timestamp":1783680119000},"source":"Crossref","is-referenced-by-count":0,"title":["Effects of captopril and losartan on early wound healing in hypertensive rats"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4305-7672","authenticated-orcid":false,"given":"Anne Caroline","family":"Braz","sequence":"first","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0389-2013","authenticated-orcid":false,"given":"Bruna Carla","family":"Hendges","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-8142","authenticated-orcid":false,"given":"Maria de Lourdes Pessole Biondo","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7871-4463","authenticated-orcid":false,"given":"Sergio Ossamu","family":"Ioshii","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1590\/abd1806-4841.20164741","article-title":"Wound healing: A literature review","volume":"91","author":"Gonzalez ACO","year":"2016","journal-title":"An Bras Dermatol"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"200223","DOI":"10.1098\/rsob.200223","article-title":"Wound healing: cellular mechanisms and pathological outcomes","volume":"10","author":"Wilkinson HN","year":"2020","journal-title":"Open Biol"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound healing: a cellular perspective","volume":"99","author":"Rodrigues M","year":"2019","journal-title":"Physiol Rev"},{"issue":"6342","key":"ref4","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1126\/science.aam7928","article-title":"Inflammation and metabolism in tissue repair and regeneration","volume":"356","author":"Eming SA","year":"2017","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cellsig.2018.07.011","article-title":"Balance and circumstance: The renin angiotensin system in wound healing and fibrosis","volume":"51","author":"Bernasconi R","year":"2018","journal-title":"Cell Signal"},{"issue":"92","key":"ref6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.matbio.2020.04.005","article-title":"Targeting the renin-angiotensin-aldosterone system in fibrosis","volume":"91","author":"AlQudah M","year":"2020","journal-title":"Matrix Biol"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"516","DOI":"10.36660\/abc.20201238","article-title":"Diretrizes brasileiras de hipertens\u00e3o arterial \u2013 2020","volume":"116","author":"Barroso WKS","year":"2021","journal-title":"Arq Bras Cardiol"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1590\/S0100-69912006000200004","article-title":"Cicatriza\u00e7\u00e3o de feridas: estudo comparativo em ratos hipertensos n\u00e3o tratados e tratados com inibidor da enzima conversora da angiotensina","volume":"33","author":"Biondo-Sim\u00f5es MLP","year":"2006","journal-title":"Rev Col Bras Cir"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1590\/S0102-86502006000300005","article-title":"Influence of arterial hypertension treated with losartan on skin healing in rats","volume":"21","author":"Biondo-Sim\u00f5es MLP","year":"2006","journal-title":"Acta Cir Bras"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1600-0625.1995.tb00056.x","article-title":"The renin-angiotensin-system in the skin. Evidence for its presence and possible functional implications","volume":"4","author":"Steckelings UM","year":"1995","journal-title":"Exp Dermatol"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1161\/HYPERTENSIONAHA.109.147843","article-title":"Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB","volume":"55","author":"Rompe F","year":"2010","journal-title":"Hypertension"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1038\/s41598-018-21600-w","article-title":"Angiotensin-converting enzyme inhibitor reduces scar formation by inhibiting both canonical and noncanonical TGF-\u03b21 pathways","volume":"8","author":"Fang QQ","year":"2018","journal-title":"Sci Rep"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/wrr.12648","article-title":"Losartan ointment relieves hypertrophic scars and keloid: A pilot study","volume":"26","author":"Hedayatyanfard K","year":"2018","journal-title":"Wound Repair Regen"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/exd.14154","article-title":"The renin-angiotensin system in cutaneous hypertrophic scar and keloid formation","volume":"29","author":"Hedayatyanfard K","year":"2020","journal-title":"Exp Dermatol"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.burns.2017.08.008","article-title":"Early intervention by Captopril does not improve wound healing of partial thickness burn wounds in a rat model","volume":"44","author":"Akershoek JJJ","year":"2018","journal-title":"Burns"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502026000100621&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:42:01Z","timestamp":1783680121000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502026000100621&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":15,"alternative-id":["S0102-86502026000100621"],"URL":"https:\/\/doi.org\/10.1590\/acb413126","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e413126"}}