{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:49:54Z","timestamp":1782730194349,"version":"3.54.5"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To evaluate the effect of Dermalix on anastomotic healing in a rat model of ischemic colon anastomosis.  Methods: Forty rats were divided into three groups: negative control (n = 10), control (n = 15), and experimental (n = 15). Only laparotomy was performed in the negative control group. In the control group, ischemia and end-to-end colon anastomosis were performed, while in the experimental group, Dermalix was applied circumferentially around the anastomosis. On postoperative day 7, anastomotic segments were evaluated for burst pressure, adhesion, and histopathological parameters.  Results: Abscess formation related to anastomotic leakage occurred in two rats in the control group and in one rat in the experimental group. Mean burst pressure was 134.7 mmHg in the control group and 194.7 mmHg in the experimental group (p = 0.005). No significant differences were observed in inflammation, epithelial regeneration, or granulation tissue formation. Neovascularization (p &lt; 0.001) and collagenization (p = 0.032) were significantly higher in the Dermalix group. There was no significant difference in adhesion or foreign body reaction.  Conclusion: Dermalix improved key histological and mechanical indicators of anastomotic healing under ischemic conditions, providing preliminary evidence of its potential as a bioactive adjunct. Further studies are warranted to confirm these findings and assess clinical relevance.<\/jats:p>","DOI":"10.1590\/acb413526","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:43:30Z","timestamp":1782729810000},"source":"Crossref","is-referenced-by-count":0,"title":["Dermalix enhances angiogenesis and collagen remodeling in an ischemic colon anastomosis rat model"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2618-3349","authenticated-orcid":false,"given":"Yasemin","family":"Keskin","sequence":"first","affiliation":[{"name":"Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4406-1019","authenticated-orcid":false,"given":"Alperen Ir\u015fat","family":"Keskin","sequence":"additional","affiliation":[{"name":"\u00dcnye State Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1824-8453","authenticated-orcid":false,"given":"Siyar","family":"Ersoz","sequence":"additional","affiliation":[{"name":"Ankara University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4961-6159","authenticated-orcid":false,"given":"Cevriye Cans\u0131z","family":"Ersoz","sequence":"additional","affiliation":[{"name":"Ankara University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7311-1807","authenticated-orcid":false,"given":"Ilknur","family":"Kepenekci Bayram","sequence":"additional","affiliation":[{"name":"Ankara University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9041-341X","authenticated-orcid":false,"given":"Ayhan B\u00fclent","family":"Erkek","sequence":"additional","affiliation":[{"name":"Ankara University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1479-666X(09)80064-4","article-title":"Managing anastomotic leaks from intestinal anastomoses","volume":"7","author":"Hyman NH","year":"2009","journal-title":"Surgeon"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.14744\/tjtes.2023.20194","article-title":"The effect of Dermalix\u00ae on colon anastomosis leakage: experimental study","volume":"29","author":"Ersoz S","year":"2023","journal-title":"Ulusal Travma ve Acil Cerrahi Derg"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/1534734620907773","article-title":"Comparative evaluation of clinical efficacy and safety of collagen laminin\u2013based dermal matrix combined with resveratrol microparticles (Dermalix) and standard wound care for diabetic foot ulcers","volume":"20","author":"\u00c7etinkalp \u015e","year":"2021","journal-title":"Int J Low Extrem Wounds"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.abb.2010.12.030","article-title":"The grape antioxidant resveratrol for skin disorders: Promise, prospects, and challenges","volume":"508","author":"Ndiaye M","year":"2011","journal-title":"Arch Biochem Biophys"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/ten.teb.2012.0437","article-title":"Three-dimensional scaffolds for tissue engineering applications: role of porosity and pore size","volume":"19","author":"Loh QL","year":"2013","journal-title":"Tissue Eng Part B Rev"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"585","DOI":"10.12968\/jowc.2016.25.10.585","article-title":"Effectiveness of hyaluronic acid and its derivatives on chronic wounds: a systematic review","volume":"25","author":"Shaharudin A","year":"2016","journal-title":"J Wound Care"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.colsurfb.2014.12.006","article-title":"Evaluation of characteristics and in vitro antioxidant properties of RSV loaded hyaluronic acid\u2013DPPC microparticles as a wound healing system","volume":"126","author":"Ero\u011flu I","year":"2015","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"1","key":"ref8","first-page":"7196","article-title":"Nanobiomaterials for vascular biology and wound management: A review","volume":"7","author":"Singh AV","year":"2018","journal-title":"Veins and Lymphatics"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1159\/000520676","article-title":"Ischemic conditioning in the right colon and terminal ileum: an experimental rat model","volume":"63","author":"Rodriguez-Leon G","year":"2022","journal-title":"Eur Surg Res"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/bjs.1800790617","article-title":"Effect of antibiotics in fibrin sealant on healing colonic anastomoses in the rat","volume":"79","author":"van der Ham AC","year":"1992","journal-title":"Br J Surg"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/SLA.0b013e318262a6cd","article-title":"Identifying important predictors for anastomotic leak after colon and rectal resection","volume":"257","author":"Trencheva K","year":"2013","journal-title":"Ann Surg"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0022-4804(88)90045-5","article-title":"The healing of colonic anastomoses after early intraperitoneal chemotherapy: An experimental study in rats","volume":"44","author":"Hillan K","year":"1988","journal-title":"J Surg Res"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/bjs.1800811140","article-title":"Experimental colonic healing in relation to timing of 5-fluorouracil therapy","volume":"81","author":"Weiber S","year":"1994","journal-title":"Br J Surg"},{"issue":"1","key":"ref14","first-page":"67","article-title":"Gastrointestinal sistemde yara iyile\u015fmesi","volume":"12","author":"K\u0131l\u0131\u00e7o\u011flu B","year":"2005","journal-title":"SD\u00dc T\u0131p Fak Derg"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.3906\/sag-1902-43","article-title":"The effect of carbon monoxide releasing molecule-2 (CORM-2) on healing of ischemic colon anastomosis in rats","volume":"51","author":"Kayap\u0131nar AK","year":"2021","journal-title":"Turk J Med Sci"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1159\/000008593","article-title":"Healing of colonic anastomoses after immediate and delayed administration of 5-fluorouracil plus folinic acid","volume":"30","author":"Kanellos I","year":"1998","journal-title":"Eur Surg Res"},{"key":"ref17","first-page":"1","article-title":"Healing of experimental colon anastomosis","volume":"566","author":"Brask\u00e9n P","year":"1991","journal-title":"Eur J Surg Suppl"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1091-255X(01)80052-4","article-title":"Effect of matrix metalloproteinase inhibition on colonic anastomotic healing in rats","volume":"5","author":"Kiyama T","year":"2001","journal-title":"J Gastrointest Surg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"100457","DOI":"10.1016\/j.tcam.2020.100457","article-title":"A review of normal intestinal healing, intestinal anastomosis, and the pathophysiology and treatment of intestinal dehiscence in foreign body obstructions in dogs","volume":"41","author":"Mullen KM","year":"2020","journal-title":"Top Companion Anim Med"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"206","DOI":"10.12968\/jowc.2019.28.4.206","article-title":"Effect of swim bladder matrix treated with hyaluronic acid on wound healing: an animal model evaluation","volume":"28","author":"Jalali S","year":"2019","journal-title":"J Wound Care"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1177\/1534734617714142","article-title":"Wound healing and anti-inflammatory effects of topical hyaluronic acid injection in surgical-site infection caused by Staphylococcus aureus","volume":"16","author":"Park JH","year":"2017","journal-title":"Int J Low Extrem Wounds"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1177\/039139889101401010","article-title":"TFE-plasma polymerized dermal sheep collagen for the repair of abdominal wall defects","volume":"14","author":"van der Laan JS","year":"1991","journal-title":"Int J Artif Organs"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/1097-4636(200102)54:2<305::AID-JBM18>3.0.CO;2-B","article-title":"A new type of surgical adhesive made from porcine collagen and polyglutamic acid","volume":"54","author":"Sekine T","year":"2001","journal-title":"J Biomed Mater Res"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s12664-020-01145-5","article-title":"Comparison of the efficacy of growth factor collagen and antibiotic collagen on colon anastomosis in experimental animals with peritonitis","volume":"40","author":"Y\u0131ld\u0131r\u0131m MA","year":"2021","journal-title":"Indian J Gastroenterol"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00384-016-2737-9","article-title":"Lack of evidence for tissue hypoxia as a contributing factor in anastomotic leak following colon anastomosis and segmental devascularization in rats","volume":"32","author":"Shakhsheer BA","year":"2017","journal-title":"Int J Colorectal Dis"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/DCR.0000000000001667","article-title":"Locally transplanted adipose stem cells reduce anastomotic leaks in ischemic colorectal anastomoses: a rat model","volume":"63","author":"Morgan A","year":"2020","journal-title":"Dis Colon Rectum"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.3390\/ijms20071523","article-title":"Resveratrol and its effects on the vascular system","volume":"20","author":"Breuss JM","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","DOI":"10.15190\/d.2021.8","article-title":"Healing of colonic anastomosis in rats under obstructive ileus conditions","volume":"9","author":"Despoudi K","year":"2020","journal-title":"Discoveries (Craiova)"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502026000100619&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:43:34Z","timestamp":1782729814000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502026000100619&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":28,"alternative-id":["S0102-86502026000100619"],"URL":"https:\/\/doi.org\/10.1590\/acb413526","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e413526"}}