{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:02:48Z","timestamp":1784901768108,"version":"3.55.0"},"reference-count":36,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To investigate the protective effects of syringic acid (SA) against testicular ischemia\u2013reperfusion (I\/R) injury during different reperfusion periods in an experimental rat model.  Methods: Forty-eight male Wistar albino rats were randomly assigned to six groups: control, sham, torsion\/detorsion (T\/D) 4 h, T\/D + SA 4 h, T\/D 24 h, and T\/D + SA 24 h. Testicular torsion was induced by 720\u00b0 rotation of the left testis for 2 h, followed by detorsion and 4 or 24 h reperfusion. SA (10 mg\/kg) was administered intraperitoneally 30 min before detorsion. Oxidative stress markers, histopathological alterations, and immunohistochemical expressions of apoptotic protease activating factor-1 (APAF-1) and inducible nitric oxide synthase were evaluated.  Results: T\/D significantly decreased total antioxidant status and glutathione levels while increasing myeloperoxidase activity and APAF-1\/inducible nitric oxide synthase (iNOS) expressions compared with controls (p &lt; 0.001). SA treatment restored antioxidant capacity and attenuated inflammatory and apoptotic responses (p &lt; 0.05). Histopathological analyses demonstrated lower Cosentino scores and higher Johnsen scores in SA-treated groups than in untreated T\/D groups (p &lt; 0.05). Malondialdehyde levels showed no significant intergroup differences.  Conclusion: SA attenuates testicular I\/R injury by reducing oxidative stress, inflammation, and apoptosis while preserving spermatogenic function and histological integrity.<\/jats:p>","DOI":"10.1590\/acb414226","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:14:36Z","timestamp":1784898876000},"source":"Crossref","is-referenced-by-count":0,"title":["Time-dependent protective effects of syringic acid following testicular torsion\u2013detorsion: an experimental rat model"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9906-8042","authenticated-orcid":false,"given":"Kenan","family":"Sabuncu","sequence":"first","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0879-9107","authenticated-orcid":false,"given":"Mehmet Ali","family":"Sezgin","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5254-2563","authenticated-orcid":false,"given":"Emre Can","family":"Polat","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6325-3297","authenticated-orcid":false,"given":"Erkan","family":"Merder","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0553-3012","authenticated-orcid":false,"given":"Alper","family":"\u00d6t\u00fcn\u00e7temur","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6042-3561","authenticated-orcid":false,"given":"Mustafa Baki","family":"\u00c7ekmen","sequence":"additional","affiliation":[{"name":"Istanbul Medeniyet University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4927-6625","authenticated-orcid":false,"given":"Saniye Ko\u00e7","family":"Ada","sequence":"additional","affiliation":[{"name":"Istanbul Medeniyet University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1083-7042","authenticated-orcid":false,"given":"Cem","family":"\u00c7omuno\u011flu","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8617-3639","authenticated-orcid":false,"given":"Levent","family":"\u00d6zcan","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","article-title":"Protective effect of oltipraz in testicular ischaemia\/reperfusion injury: An experimental study","volume":"54","author":"Can O","year":"2022","journal-title":"Andrologia"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jpurol.2019.10.006","article-title":"Protective effect of hydrogen sulfide on experimental testicular ischemia reperfusion in rats","volume":"16","author":"Bozkurt M","year":"2020","journal-title":"J Pediatr Urol"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1111\/and.14000","article-title":"Protective effect of liraglutide on experimental testicular ischaemia reperfusion in rats","volume":"53","author":"Degirmentepe RB","year":"2021","journal-title":"Andrologia"},{"issue":"3","key":"ref4","first-page":"265","article-title":"Ameliorative effect of Allium 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analysis of spermatogenesis after short-term testicular torsion in rats","volume":"94","author":"Katami H","year":"2023","journal-title":"Pediatr Res"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","DOI":"10.1111\/and.13922","article-title":"The effects of pirfenidone on ischaemia-reperfusion injury in testicular torsion-induced rat model","volume":"53","author":"Kolukcu E","year":"2021","journal-title":"Andrologia"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502026000100626&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:14:41Z","timestamp":1784898881000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502026000100626&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":36,"alternative-id":["S0102-86502026000100626"],"URL":"https:\/\/doi.org\/10.1590\/acb414226","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e414226"}}