{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:30:55Z","timestamp":1786710655571,"version":"build-2736575974"},"reference-count":18,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To evaluate through histological analysis the application of starch-melamine film and bixin (Bixa orellana L.) in wound healing in Wistar rats.  Methods: Eighteen male Wistar rats were randomly assigned to three groups (n = 6 per group): Group 1 (control), cutaneous wound without topical treatment; Group 2, cutaneous wound treated with a bixin-free film; and Group 3, cutaneous wound treated with a film containing bixin. Wound healing progression was monitored by photographic documentation and histological analysis on postoperative days 3, 7, and 14.  Results: At the end of three days, the three groups showed similar histological aspects with incipient re-epithelialization and edematous extracellular matrix (ECM). After seven days, the edema decreased, and the ECM appeared much more compact. After 14 days, the newly formed epidermis extended toward the wound center, but re-epithelialization was not complete in any group. Fibroblast proliferation and maturation were accentuated in all three groups. Group 3 (bixin group) exhibited wounds with a dense matrix, increased collagen deposition, and a minimal inflammatory cell infiltrate.  Conclusion: The starch-melamine composite associated with bixin demonstrated potential to enhance tissue repair and modulate the inflammatory response.<\/jats:p>","DOI":"10.1590\/acb414826","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:36:09Z","timestamp":1786707369000},"source":"Crossref","is-referenced-by-count":0,"title":["Application of melamine-starch and bixin film (Bixa orellana L.) in wound healing"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1475-6805","authenticated-orcid":false,"given":"L\u00facia Rosa Reis de Ara\u00fajo","family":"Carvalho","sequence":"first","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8330-3247","authenticated-orcid":false,"given":"Maria do Amparo Veloso","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Centro de Tecnologia Educacional em Biotecnologia,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6184-8003","authenticated-orcid":false,"given":"Ant\u00f4nio Luiz Martins","family":"Maia","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Piau\u00ed,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8485-6222","authenticated-orcid":false,"given":"Luciano Reis de Araujo","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3911-717X","authenticated-orcid":false,"given":"Isabella Mousinho Marinho dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Hospital S\u00e3o Marcos,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8766-8593","authenticated-orcid":false,"given":"Lucielma Salmito Soares","family":"Pinto","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7117-8784","authenticated-orcid":false,"given":"Jos\u00e9 Figueredo","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Piau\u00ed,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9877-1994","authenticated-orcid":false,"given":"Jose Zilton Lima Verde","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Piau\u00ed,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-2020","authenticated-orcid":false,"given":"Jos\u00e9 Ribeiro dos","family":"Santos J\u00fanior","sequence":"additional","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"200223","DOI":"10.1098\/rsob.200223","article-title":"Wound healing: Cellular mechanisms and pathological outcomes","volume":"10","author":"Wilkinson HN","year":"2020","journal-title":"Open Biol"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.3390\/polym14102023","article-title":"Modified starch-based adhesives: A review","volume":"14","author":"Watcharakitti J","year":"2022","journal-title":"Polymers"},{"issue":"4","key":"ref3","first-page":"393","article-title":"Wound healing: current concepts and auxiliary resources - Part I","volume":"78","author":"Mandelbaum SH","year":"2003","journal-title":"An Bras Dermatol"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0002-9610(02)00813-9","article-title":"Principles and practices for treatment of cutaneous wounds with cultured skin substitutes","volume":"183","author":"Boyce ST","year":"2002","journal-title":"Am J Surg"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.progpolymsci.2011.06.003","article-title":"Alginate: Properties and biomedical applications","volume":"37","author":"Lee KY","year":"2012","journal-title":"Prog Polym Sci"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3390\/agronomy11050813","article-title":"Polysaccharides as edible films and coatings: Characteristics and influence on fruit and vegetable quality\u2014A review","volume":"11","author":"Kocira A","year":"2021","journal-title":"Agronomy"},{"issue":"19","key":"ref7","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.3390\/ijms21197011","article-title":"A review of starch biosynthesis in relation to the building block-backbone model","volume":"21","author":"Tetlow IJ","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"114961","DOI":"10.1016\/j.jep.2021.114961","article-title":"Bixa orellana L. (Achiote, Annatto) as an antimicrobial agent: A scoping review of its efficiency and technological prospecting","volume":"287","author":"Santos DC","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"ref9","article-title":"An efficient and mild recycling of waste melamine formaldehyde foams by alkaline hydrolysis","author":"Wu S","year":"2022","journal-title":"SSRN Electron J"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1089\/pho.2007.2052","article-title":"Comparative study of the effects of laser photobiomodulation on the healing of third-degree burns \u2013 histological study in rats","volume":"26","author":"Meirelles GC","year":"2008","journal-title":"Photomed Laser Surg"},{"issue":"6","key":"ref11","article-title":"Evaluation of a composite (starch-melamine) in film form with bixin to be applied as a healing product","volume":"22","author":"Carvalho LRRA","year":"2025","journal-title":"Cad Pedag\u00f3gico"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"124386","DOI":"10.1016\/j.ijbiomac.2023.124386","article-title":"Structural characterization and anti-inflammatory activity of polysaccharides from Astragalus membranaceus","volume":"241","author":"Chen G","year":"2023","journal-title":"Int J Biol Macromol"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","DOI":"10.33448\/rsd-v10i6.15331","article-title":"Cellulose (Mangifera indica) modified by melamine-silica applied in the treatment of effluents with chemically assisted precipitation","volume":"10","author":"Mesquita J\u00fanior JS","year":"2021","journal-title":"Res Soc Dev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"130499","DOI":"10.1016\/j.molstruc.2021.130499","article-title":"Physical-chemical characterization, controlled release, and toxicological potential of galactomannan-bixin microparticles","volume":"1239","author":"Pascoal KLL","year":"2021","journal-title":"J Mol Struct"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"103465","DOI":"10.1016\/j.fbio.2023.103465","article-title":"Utilization of a portable Raman spectrometer combined with a PCA-SVM model for starch type differentiation","volume":"57","author":"Liu T","year":"2024","journal-title":"Food Biosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"103404","DOI":"10.1016\/j.ijadhadh.2023.103404","article-title":"Preparation optimization by response surface and performance characterization of PEG-urea-dialdehyde starch adhesive","volume":"125","author":"Chen Q","year":"2023","journal-title":"Int J Adhes Adhes"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3390\/antiox9060505","article-title":"Carotenoids and chlorophylls as antioxidants","volume":"9","author":"P\u00e9rez-G\u00e1lvez A","year":"2020","journal-title":"Antioxidants (Basel)"},{"issue":"6342","key":"ref18","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1126\/science.aam7928","article-title":"Inflammation and metabolism in tissue repair and regeneration","volume":"356","author":"Eming SA","year":"2017","journal-title":"Science"}],"container-title":["Acta Cir\u00fargica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0102-86502026000100629&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:36:12Z","timestamp":1786707372000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-86502026000100629&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":18,"alternative-id":["S0102-86502026000100629"],"URL":"https:\/\/doi.org\/10.1590\/acb414826","relation":{},"ISSN":["1678-2674","0102-8650"],"issn-type":[{"value":"1678-2674","type":"electronic"},{"value":"0102-8650","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e414826"}}