{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:10:41Z","timestamp":1786122641277,"version":"build-2736575974"},"reference-count":45,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Projects Coordination Unit of A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University","award":["TIP.24.012"],"award-info":[{"award-number":["TIP.24.012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To evaluate the protective effects of nicotinamide mononucleotide (NMN), a NAD+ precursor, on kidney tissue in rats with sepsis induced by cecal ligation and puncture model.  Methods: In this study, 28 female Sprague Dawley rats were randomly divided into four equal groups: control, sham, sepsis, and sepsis+NMN (500 mg\/kg, i.p.). Kidney tissues taken 24 hours after the sepsis model were histopathologically evaluated under light microscopy for tubular damage, glomerular congestion, and inflammatory infiltration parameters.  Results: Histopathological examination revealed severe tubular injury, marked glomerular congestion, and dense inflammatory cell infiltration in the kidney tissues of the sepsis group. In the group treated with NMN, a significant reduction in these pathological findings was observed, while the glomerular structure and tubular architecture were preserved. Semi-quantitative histopathological scoring confirmed significantly increased renal injury in the sepsis group and significant attenuation of tissue damage following NMN treatment.  Conclusion: The data obtained showed that NMN may play an important cytoprotective role in sepsis-induced acute kidney injury by preserving tissue architecture. More comprehensive molecular and biochemical studies are needed to fully elucidate the therapeutic potential and mechanisms of action of NMN.<\/jats:p>","DOI":"10.1590\/acb414926","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T10:43:49Z","timestamp":1786099429000},"source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the effects of nicotinamide mononucleotide on kidney damage in rats with cecal ligation and perforation sepsis model"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-7784","authenticated-orcid":false,"given":"Ayla","family":"Arslan","sequence":"first","affiliation":[{"name":"A\u011fri \u0130brahim \u00c7e\u00e7en University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4346-7474","authenticated-orcid":false,"given":"Dilek Vural","family":"Kele\u015f","sequence":"additional","affiliation":[{"name":"Kirklareli University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9577-986X","authenticated-orcid":false,"given":"Se\u00e7il Nazife","family":"Parlak","sequence":"additional","affiliation":[{"name":"A\u011fri \u0130brahim \u00c7e\u00e7en University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1673-5661","authenticated-orcid":false,"given":"Seda","family":"Yakut","sequence":"additional","affiliation":[{"name":"Burdur Mehmet Akif Ersoy University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6268-8594","authenticated-orcid":false,"given":"Habibe","family":"G\u00fcndo\u011fdu","sequence":"additional","affiliation":[{"name":"Atat\u00fcrk University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6151-4078","authenticated-orcid":false,"given":"\u0130rem","family":"Arslant\u00fcrk","sequence":"additional","affiliation":[{"name":"A\u011fri \u0130brahim \u00c7e\u00e7en University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4992-6915","authenticated-orcid":false,"given":"G\u00f6k\u00e7e Ba\u011fc\u0131","family":"Uzun","sequence":"additional","affiliation":[{"name":"Malatya Turgut \u00d6zal University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7187-1557","authenticated-orcid":false,"given":"Berna \u00d6zt\u00fcrk","family":"Karag\u00f6z","sequence":"additional","affiliation":[{"name":"A\u011fri \u0130brahim \u00c7e\u00e7en University,  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