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Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To evaluate the effectiveness of polymer-based strategies for preventing intra-abdominal adhesions after small colon enterotomy and enterorrhaphy in a rabbit experimental model.  Methods: Twenty-four female New Zealand White rabbits were randomly allocated into four groups (n = 6): film composed of a blend of sodium carboxymethylcellulose and polyvinyl alcohol (NaCMC-PVA); NaCMC-PVA-streptokinase (STP) film; intra-abdominal STP infusion; and no treatment. Hematological parameters were assessed preoperatively and at three and seven days postoperatively. Macroscopic evaluation of intra-abdominal adhesions and histopathological analysis of the enterorrhaphy site were performed on postoperative day 7. Results were compared within and between experimental groups.  Results: Treated groups exhibited fewer hematological alterations compared with the control group. No statistically significant differences were observed among groups regarding adhesion severity or histopathological scores (p&gt; 0.05). The NaCMC\u2013PVA film showed the lowest absolute incidence of adhesions and did not impair intestinal remesothelialization.  Conclusion: Based on the biological findings from this study, the NaCMC\u2013PVA film exhibited acceptable handling characteristics and biological compatibility. These findings suggest its potential as a mechanical barrier for preventing abdominal adhesion. However, further studies with larger sample sizes and longer follow-up periods are required to confirm its effectiveness.<\/jats:p>","DOI":"10.1590\/acb415226","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:11:59Z","timestamp":1789132319000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of polymeric films and streptokinase for prevention of postoperative intra-abdominal adhesion in rabbits"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2037-8572","authenticated-orcid":false,"given":"Luisa Gouv\u00eaa","family":"Teixeira","sequence":"first","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0042-0040","authenticated-orcid":false,"given":"Helena Cristina Delgado","family":"Brito","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-6162","authenticated-orcid":false,"given":"Bruna Nunes","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-2566","authenticated-orcid":false,"given":"Julielton de Souza","family":"Barata","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2961-4588","authenticated-orcid":false,"given":"Rozana da Rocha","family":"Adams","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7107-6032","authenticated-orcid":false,"given":"Let\u00edcia Abrah\u00e3o","family":"Anai","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8718-1462","authenticated-orcid":false,"given":"Fernanda","family":"Martinato","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5131-9255","authenticated-orcid":false,"given":"Andresa","family":"Matsui","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0026-5431","authenticated-orcid":false,"given":"Rossana Mara da Silva Moreira","family":"Thir\u00e9","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4539-1802","authenticated-orcid":false,"given":"\u00c1ureo Evangelista","family":"Santana","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/00000658-200202000-00006","article-title":"Fewer intraperitoneal adhesions with use of hyaluronic acid-carboxymethylcellulose membrane: a randomized clinical trial","volume":"235","author":"Jeekel H","year":"2002","journal-title":"Ann Surg"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.cveq.2003.08.014","article-title":"Prevention and treatment of gastrointestinal adhesions","volume":"19","author":"Eggleston RB","year":"2003","journal-title":"Vet Clin North Am Equine Pract"},{"issue":"2","key":"ref3","first-page":"123","article-title":"Intra-abdominal adhesions in horses","volume":"8","author":"Palma MLM","year":"2005","journal-title":"Rev Educ Contin. 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