{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:45:35Z","timestamp":1791805535341,"version":"4.3.4"},"reference-count":45,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["159,235\/2025-1"],"award-info":[{"award-number":["159,235\/2025-1"]}],"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["159,235\/2025-1"],"award-info":[{"award-number":["159,235\/2025-1"]}],"id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To evaluate bone repair in critical size calvarial defects (8 mm) in rats treated with Croton lechleri sap (dragon\u2019s blood sap, DBS) combined with Hemospon\u00ae and Alveolex\u00ae.  Methods: Seventy-two Wistar rats were divided into six groups: G1, Hemospon\u00ae; G2, Hemospon\u00ae + DBS; G3, Alveolex\u00ae; G4, Alveolex\u00ae + DBS; C\u2212, blood clot; and C+, LuminaCoat\u00ae membrane. At 30 and 60 days, specimens were submitted to histological and histomorphometric analysis, quantifying newly formed bone, residual biomaterial, and connective tissue.  Results: No statistically significant differences were observed among groups in new bone formation. At 30 days, G3 presented the highest mean of newly formed bone (18.6 \u00b1 6.8%), followed by G2 (16.0 \u00b1 4.8%). G4 presented the lowest mean (10.7 \u00b1 1.3%). At 60 days, C+ exhibited the greatest bone formation (29.5 \u00b1 21.0%). G2 showed the highest biomaterial persistence at 30 (19.4 \u00b1 0.6%) and 60 days (17.4 \u00b1 3.9%). G3 presented the lowest connective tissue density at 30 days (49.2 \u00b1 6.3%); C+ exhibited the lowest value at 60 days (38.9 \u00b1 18.1%).  Conclusion: Hemospon\u00ae associated with DBS proved to be the most promising osteoconductive system, favoring biomaterial persistence and reducing fibrogenesis, whereas the association with Alveolex\u00ae was less favorable. The DBS shows biotechnological potential, but its stabilizing effect on the scaffold requires further investigation.<\/jats:p>","DOI":"10.1590\/acb415926","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:57:04Z","timestamp":1791802624000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the osteoconductive potential of Croton lechleri sap associated with collagen or wax-based carriers in critical-size bone defects in rat calvaria"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3352-3097","authenticated-orcid":false,"given":"Diego Armando Leite","family":"Carvalho","sequence":"first","affiliation":[{"name":"Universidade Federal do Cear\u00e1","place":["Fortaleza, CE, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8764-1111","authenticated-orcid":false,"given":"Gustavo Sousa","family":"Marques","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1","place":["Sobral, CE, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0265-4878","authenticated-orcid":false,"given":"Yanna Ribeiro","family":"Mac\u00eado","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1","place":["Sobral, CE, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4815-6357","authenticated-orcid":false,"given":"Igor Iuco","family":"Castro-Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1","place":["Fortaleza, CE, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.msec.2018.10.022","article-title":"Investigating the 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