{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:40:26Z","timestamp":1792410026083,"version":"4.4.0"},"reference-count":27,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u00c7ukurova University \u2013 Scientific Research Projects Coordination Unit","award":["TTU-2021-14212"],"award-info":[{"award-number":["TTU-2021-14212"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cir. Bras."],"abstract":"<jats:p>ABSTRACT  Purpose: To evaluate the effects of intraperitoneal Hypericum perforatum oil (St. John\u2019s Wort oil, SJWO) on systemic inflammation and peritoneal histopathology in experimental peritonitis.  Methods: Forty-two male Wistar Albino rats were randomized into seven groups (n = 6): control, SJWO, olive oil, peritonitis, peritonitis + saline, peritonitis + SJWO, and peritonitis + olive oil. Peritonitis was induced with freshly prepared autologous fecal suspension, and treatments were administered intraperitoneally at 48 h. On day 5, plasma inflammatory markers, peritoneal thickness, and histopathological scores were assessed blinded.  Results: The greatest weight loss was seen in the peritonitis group (p = 0.002). SJWO did not consistently reduce systemic inflammatory markers. Compared with peritonitis + saline, peritonitis + SJWO showed lower parietal fibrosis and vascular proliferation scores (rank-biserial correlation for each outcome, r rb = -0.833; 95% confidence interval -1.000 to -0.500), but visceral fibrosis was not reduced.  Conclusion: Intraperitoneal SJWO did not suppress systemic inflammation. The lower early parietal fibrosis and vascular proliferation scores are exploratory because the effect was not observed in visceral tissue, and adhesion formation was not directly assessed.<\/jats:p>","DOI":"10.1590\/acb416026","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:48:00Z","timestamp":1792406880000},"source":"Crossref","is-referenced-by-count":0,"title":["The effect of intraperitoneal St. John\u2019s Wort oil (Hypericum perforatum) in an experimental peritonitis model"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8502-4367","authenticated-orcid":false,"given":"Yunus","family":"Kayci","sequence":"first","affiliation":[{"name":"University of Health Sciences","place":["Adana, Turkey"]},{"name":"\u00c7ukurova University","place":["Adana, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5262-0346","authenticated-orcid":false,"given":"Burak","family":"Yavuz","sequence":"additional","affiliation":[{"name":"\u00c7ukurova University","place":["Adana, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0313-5467","authenticated-orcid":false,"given":"Ahmet Onur","family":"Demirel","sequence":"additional","affiliation":[{"name":"\u00c7ukurova University","place":["Adana, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4918-191X","authenticated-orcid":false,"given":"Ibrahim","family":"\u00c7o\u011fal","sequence":"additional","affiliation":[{"name":"\u00c7ukurova University","place":["Adana, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2302-6475","authenticated-orcid":false,"given":"Z\u00fclfi","family":"Zahidli","sequence":"additional","affiliation":[{"name":"\u00c7ukurova University","place":["Adana, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4951-8703","authenticated-orcid":false,"given":"Kivilcim Eren","family":"Ate\u015f","sequence":"additional","affiliation":[{"name":"\u00c7ukurova University","place":["Adana, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1305-2056","authenticated-orcid":false,"given":"U\u011fur","family":"Topal","sequence":"additional","affiliation":[{"name":"\u00c7ukurova University","place":["Adana, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1560-7740","authenticated-orcid":false,"given":"Ismail Cem","family":"Eray","sequence":"additional","affiliation":[{"name":"\u00c7ukurova University","place":["Adana, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9500-4175","authenticated-orcid":false,"given":"Mustafa Yal\u00e7\u0131n","family":"Keke\u00e7","sequence":"additional","affiliation":[{"name":"\u00c7ukurova University","place":["Adana, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13017-018-0183-4","article-title":"Closed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (the COOL trial): study protocol for a randomized controlled trial","volume":"13","author":"Kirkpatrick AW","year":"2018","journal-title":"World J Emerg Surg"},{"issue":"6","key":"ref2","article-title":"Roles of IL-1 and TNF in the decreased ileal muscle contractility induced by lipopolysaccharide","volume":"276","author":"Lodato RF","year":"1999","journal-title":"Am J Physiol"},{"issue":"4","key":"ref3","first-page":"281","article-title":"Effects of peritoneal lavage and dry cleaning on bacterial translocation in a model of peritonitis developed using cecal ligation and puncture","volume":"24","author":"Ko\u00e7 TR","year":"2018","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"issue":"4","key":"ref4","first-page":"107","article-title":"Intraabdominal lavage of hypochlorous acid: a new paradigm for the septic and open abdomen","volume":"32","author":"Fern\u00e1ndez LG","year":"2020","journal-title":"Wounds"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.ijporl.2015.05.009","article-title":"The effect of Hypericum perforatum L. 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