{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:14:56Z","timestamp":1760188496504},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>A gravidez associada \u00e0 s\u00edndrome de Cushing (SC) \u00e9 quadro raro e est\u00e1 relacionada com hipertens\u00e3o arterial severa em 64,6% dos casos, al\u00e9m de infertilidade e abortamento em 75% das pacientes com SC. Quando ocorre a gravidez, a causa mais freq\u00fcente do hipercortisolismo \u00e9 o adenoma adrenal produtor de cortisol. Uma das principais complica\u00e7\u00f5es da hipertens\u00e3o arterial na gravidez \u00e9 a HELLP s\u00edndrome. Os autores relatam dois casos de gesta\u00e7\u00e3o em paciente portadora de s\u00edndrome de Cushing, que evolu\u00edram com quadro s\u00fabito e severo de HELLP s\u00edndrome e conseq\u00fcente progress\u00e3o para o \u00f3bito fetal. O primeiro caso foi ocasionado por adenoma adrenal e o segundo, por um carcinoma de supra-renal. A gesta\u00e7\u00e3o associada \u00e0 s\u00edndrome de Cushing predisp\u00f5e a situa\u00e7\u00f5es amea\u00e7adoras \u00e0 vida, como a HELLP s\u00edndrome, devendo-se dar aten\u00e7\u00e3o especial \u00e0 paciente nesses casos. O diagn\u00f3stico precoce permite o tratamento espec\u00edfico em tempo h\u00e1bil, tentando reduzir a alta morbi-mortalidade nesses casos.<\/jats:p>","DOI":"10.1590\/s0004-27302004000300015","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T20:04:20Z","timestamp":1115928260000},"page":"419-422","source":"Crossref","is-referenced-by-count":2,"title":["HELLP s\u00edndrome associada \u00e0 s\u00edndrome de Cushing: relato de dois casos"],"prefix":"10.1590","volume":"48","author":[{"given":"Rodrigo F.","family":"Castro","sequence":"first","affiliation":[{"name":"Santa Casa de Belo Horizonte"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederico F.R.","family":"Maia","sequence":"additional","affiliation":[{"name":"Santa Casa de Belo Horizonte"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f4nio R.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Santa Casa de Belo Horizonte"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saulo","family":"Purisch","sequence":"additional","affiliation":[{"name":"Santa Casa de Belo Horizonte"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria R.","family":"Calsolari","sequence":"additional","affiliation":[{"name":"Santa Casa de Belo Horizonte"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia A.F.C.","family":"Menezes","sequence":"additional","affiliation":[{"name":"Santa Casa de Belo Horizonte"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana Maria N.","family":"Vict\u00f3ria","sequence":"additional","affiliation":[{"name":"Santa Casa de Belo Horizonte"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"130","article-title":"Cushing's syndrome in pregnancy","volume":"79","author":"Buescher MA","year":"1992","journal-title":"Obstet Gynecol","ISSN":"http:\/\/id.crossref.org\/issn\/0029-7844","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0889-8529(18)30088-4","article-title":"Cushing's syndrome and pregnancy","volume":"23","author":"Sheller LR","year":"1994","journal-title":"Endocrinol Metab Clin North Am","ISSN":"http:\/\/id.crossref.org\/issn\/0889-8529","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0889-8545(21)00184-4","article-title":"Complicated postpartum preeclampsia-eclampsia","volume":"22","author":"Magann EF","year":"1995","journal-title":"Obstet Gynecol Clin North Am","ISSN":"http:\/\/id.crossref.org\/issn\/0889-8545","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/0002-9378(93)90043-I","article-title":"Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP Syndrome)","volume":"169","author":"Sibai BM","year":"1993","journal-title":"Am J Obstet Gynecol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9378","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000009958","article-title":"Cushing's syndrome in pregnancy secondary to adrenal adenoma","volume":"45","author":"Lo KW","year":"1998","journal-title":"Gynecol Obstet Invest","ISSN":"http:\/\/id.crossref.org\/issn\/0378-7346","issn-type":"print"},{"key":"ref6","first-page":"201","article-title":"Gravidez na s\u00edndrome de Cushing: relato de casos","volume":"37","author":"Puiatti OW","year":"1993","journal-title":"Arq Bras Endocrinol Metab","ISSN":"http:\/\/id.crossref.org\/issn\/0004-2730","issn-type":"print"},{"key":"ref7","first-page":"15","article-title":"Pregnancy-induced Cushing's syndrome in multiple pregnancies","volume":"81","author":"Wallace C","year":"1996","journal-title":"J Clin Endocrinol Metab","ISSN":"http:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1056\/NEJM199607253350407","article-title":"Treatment of hypertension in pregnancy","volume":"335","author":"Sibai BM","year":"1996","journal-title":"N Eng J Med","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0889-8553(21)00606-3","article-title":"The syndrome of preeclampsia","volume":"21","author":"Barron W","year":"1992","journal-title":"Gastroenterol Clin North Am","ISSN":"http:\/\/id.crossref.org\/issn\/0889-8553","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0002-9378(95)90099-3","article-title":"Pregnancies complicated by HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): subsequent pregnancy outcome and long-term prognosis","volume":"172","author":"Sibai BM","year":"1995","journal-title":"Am J Obstet Gynecol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9378","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1056\/NEJM199608223350807","article-title":"Liver disease in pregnancy","volume":"335","author":"Tamsin AK","year":"1996","journal-title":"N Eng J Med","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1210\/jcem-51-3-466","article-title":"Diurnal patterns and regulation of cortisol secretion in pregnancy","volume":"51","author":"Nolten WE","year":"1980","journal-title":"J Clin Endocrinol Metab","ISSN":"http:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/0002-9378(94)90149-X","article-title":"Placental corticotrophin-releasing hormone and the hypercortisolism of pregnancy","volume":"171","author":"Goland M","year":"1994","journal-title":"Am J Obstet Gynecol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9378","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1172\/JCI113585","article-title":"Characterization and gestational regulation of corticotrophin-releasing hormone messenger RNA in human placenta","volume":"82","author":"Frim DM","year":"1988","journal-title":"J Clin Invest","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/00365517309082426","article-title":"Plasma and urinary cortisol in pregnancy and during estrogen-gestagen treatment","volume":"31","author":"Lindholm J","year":"1973","journal-title":"Scand J Clin Lab Invest","ISSN":"http:\/\/id.crossref.org\/issn\/0036-5513","issn-type":"print"}],"container-title":["Arquivos Brasileiros de Endocrinologia &amp; Metabologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abem\/v48n3\/a15v48n3.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T22:44:10Z","timestamp":1625957050000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-27302004000300015&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["S0004-27302004000300015"],"URL":"https:\/\/doi.org\/10.1590\/s0004-27302004000300015","relation":{},"ISSN":["0004-2730"],"issn-type":[{"value":"0004-2730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}