{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T05:18:12Z","timestamp":1735795092495,"version":"3.32.0"},"reference-count":21,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>Mulher de 21 anos apresenta hist\u00f3ria de 2 anos de irregularidade menstrual, com per\u00edodos de amenorr\u00e9ia de at\u00e9 8 meses e ganho ponderal e h\u00e1 1 ano galactorr\u00e9ia e cefal\u00e9ia holocraniana. Exames da ocasi\u00e3o: TSH: 1192 mUI\/ml (0,27-4,2); T4T:1,0 mg\/dl (4,4-11,4) ; T3T: 0,41 ng\/ml (0,7-2,1); prolactina: 69,2 ng\/ml (3-20). Em servi\u00e7o de endocrinologia foi confirmado quadro de mixedema acompanhado de galactorr\u00e9ia. Resson\u00e2ncia magn\u00e9tica (RM) de hipot\u00e1lamo-hip\u00f3fise mostrou les\u00e3o expansiva intra e supra selar com 1,9 x 1,4 x 1,9 cm nos seus maiores di\u00e2metros, determinando compress\u00e3o e desvio do quiasma \u00f3ptico. Diante da possibilidade de hiperplasia das c\u00e9lulas produtoras de TSH, optamos por iniciar o tratamento do hipotireoidismo com levotiroxina. Ap\u00f3s 2 meses de tratamento e normaliza\u00e7\u00e3o dos n\u00edveis s\u00e9ricos dos horm\u00f4nios tireoidianos e do TSH, nova RM mostrou hip\u00f3fise de tamanho normal. A regress\u00e3o do volume hipofis\u00e1rio ap\u00f3s terapia com levotiroxina confirmou a hip\u00f3tese diagn\u00f3stica de hiperplasia hipofis\u00e1ria decorrente do hipotireoidismo prim\u00e1rio. Nossos achados refor\u00e7am a import\u00e2ncia da avalia\u00e7\u00e3o dos horm\u00f4nios tireoideanos e TSH na investiga\u00e7\u00e3o de aumento de volume hipofis\u00e1rio prevenindo uma cirurgia desnecess\u00e1ria.<\/jats:p>","DOI":"10.1590\/s0004-27302004000300016","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T20:04:20Z","timestamp":1115928260000},"page":"423-426","source":"Crossref","is-referenced-by-count":3,"title":["Hipotireoidismo prim\u00e1rio simulando volumoso macroadenoma hipofis\u00e1rio"],"prefix":"10.1590","volume":"48","author":[{"given":"Carolina C. R.","family":"Bet\u00f4nico","sequence":"first","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzan C. 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