{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:00:40Z","timestamp":1789178440878,"version":"build-2803163510"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p>Complexo de Carney (CNC) pode ser definido como uma forma de neoplasia end\u00f3crina m\u00faltipla familial associada a altera\u00e7\u00e3o de pigmenta\u00e7\u00e3o cut\u00e2nea e de mucosa, doen\u00e7a nodular pigmentosa prim\u00e1ria das adrenais, mixomas card\u00edacos e cut\u00e2neos, adenomas hipofis\u00e1rios produtores de GH e PRL, neoplasia testicular, adenoma ou carcinoma de tire\u00f3ide, al\u00e9m de cistos ovarianos. CNC tem heran\u00e7a autoss\u00f4mica dominante e possui manifesta\u00e7\u00f5es cl\u00ednicas que s\u00e3o, em alguns aspectos, similares \u00e0s da s\u00edndrome de McCune-Albright. Recentemente, genes envolvidos na via de sinaliza\u00e7\u00e3o dependente de AMPc foram implicados na etiologia do CNC. Vamos apresentar, inicialmente, um caso de um paciente masculino de 17 anos com doen\u00e7a adrenal nodular pigmentosa, lentiginose facial e osteoporose severa. A seguir, procuramos analisar os aspectos cl\u00ednicos e a gen\u00e9tica molecular do CNC, assim como descrever os crit\u00e9rios diagn\u00f3sticos e recomenda\u00e7\u00f5es para o seguimento.<\/jats:p>","DOI":"10.1590\/s0004-27302004000400016","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T16:04:42Z","timestamp":1115913882000},"page":"544-554","source":"Crossref","is-referenced-by-count":7,"title":["Complexo de Carney: relato de um caso e revis\u00e3o da literatura"],"prefix":"10.1590","volume":"48","author":[{"given":"Madson Q. de","family":"Almeida","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C. B. 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