{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:29:22Z","timestamp":1792524562951,"version":"4.5.0"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p>O hiperparatireoidismo prim\u00e1rio (HPP) \u00e9 uma doen\u00e7a metab\u00f3lica que resulta da secre\u00e7\u00e3o anormal do horm\u00f4nio da paratire\u00f3ide (PTH), sendo uma das causas mais comuns de hipercalcemia na popula\u00e7\u00e3o geral. Apresentamos o caso de uma paciente de 47 anos, com diagn\u00f3stico pr\u00e9vio de l\u00fapus eritematoso sist\u00eamico (LES) h\u00e1 dois anos, que apresentou manifesta\u00e7\u00f5es cl\u00ednicas (dor \u00f3ssea difusa, labilidade emocional, tumora\u00e7\u00e3o em ramo mandibular esquerdo) e laboratoriais (c\u00e1lcio s\u00e9rico= 13,5mg\/dL, fosfato= 1,8mg\/dL, fosfatase alcalina= 3.028U\/L, PTH intacto= 1472pg\/dL) que culminaram com o diagn\u00f3stico de HPP, complementado pelo estudo an\u00e1tomo-patol\u00f3gico, que evidenciou adenoma de paratire\u00f3ide. Ap\u00f3s o tratamento com calcitonina nasal 400UI\/dia, pamidronato 90mg IV\/semana e, por fim, a paratireoidectomia subtotal, a paciente apresentou melhora do quadro cl\u00ednico e normaliza\u00e7\u00e3o dos exames laboratoriais. A presente descri\u00e7\u00e3o se constitui no segundo caso relatado na literatura, com tal associa\u00e7\u00e3o de doen\u00e7as. Embora os mecanismos etiopatog\u00eanicos do HPP em LES n\u00e3o estejam ainda definidos, essa associa\u00e7\u00e3o deve ser sempre lembrada, uma vez que a estrat\u00e9gia terap\u00eautica tende a mudar completamente.<\/jats:p>","DOI":"10.1590\/s0004-27302004000400017","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T20:04:42Z","timestamp":1115928282000},"page":"555-558","source":"Crossref","is-referenced-by-count":11,"title":["Hiperparatireoidismo prim\u00e1rio em paciente com l\u00fapus eritematoso sist\u00eamico"],"prefix":"10.1590","volume":"48","author":[{"given":"Liliana D.","family":"Galr\u00e3o","sequence":"first","affiliation":[{"name":"Hospital Santa Izabel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella V.","family":"Lima","sequence":"additional","affiliation":[{"name":"Hospital Santa Izabel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza","family":"Santos","sequence":"additional","affiliation":[{"name":"Hospital Santa Izabel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mittermayer B.","family":"Santiago","sequence":"additional","affiliation":[{"name":"Hospital Santa Izabel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"302","key":"ref1","first-page":"189","article-title":"Primary hyperparathyroidism","volume":"24","author":"Heath H 3rd","year":"1980","journal-title":"Incidence, morbidity, and economic impact in a community. 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