{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:47:21Z","timestamp":1770500841847,"version":"3.49.0"},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p>Glucocorticoid-remediable aldosteronism (GRA) is a monogenic form of human hypertension that predisposes to cerebral hemorrhage. As a result of a chimeric gene duplication, aldosterone is ectopically synthesized in the cortisol-secreting zona fasciculata of the adrenal gland under the control of adrenocorticotropin (ACTH). Hypertension frequently has its onset during childhood and is usually refractory to standard anti-hypertensives such as ACE inhibitors and beta-blockers. Hypokalemia can develop in those treated with a potassium-wasting diuretic, but random potassium levels are usually normal. Diagnosis has been facilitated by the availability of a genetic test. Suppression of ACTH release with exogenous dexamethasone is a useful diagnostic and therapeutic strategy. Treatment with the mineralocorticoid receptor antagonists spironolactone and epleronone is also efficacious. The diagnosis of GRA facilitates directed therapies and screening of at-risk individuals and kindreds.<\/jats:p>","DOI":"10.1590\/s0004-27302004000500014","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T16:04:58Z","timestamp":1115913898000},"page":"682-686","source":"Crossref","is-referenced-by-count":15,"title":["Glucocorticoid-remediable aldosteronism"],"prefix":"10.1590","volume":"48","author":[{"given":"Graham T.","family":"McMahon","sequence":"first","affiliation":[{"name":"Brigham & Women's Hospital; Harvard,  USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Dluhy","sequence":"additional","affiliation":[{"name":"Brigham & Women's Hospital; Harvard,  USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"1109","article-title":"Hypertension, increased aldosterone secretion and low plasma renin activity relieved by 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