{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:42:03Z","timestamp":1793216523929,"version":"4.5.0"},"reference-count":8,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p>A S\u00edndrome de Cushing compreende os sinais e sintomas associados com uma exposi\u00e7\u00e3o prolongada a n\u00edveis impropriamente elevados de glicocortic\u00f3ide livre no plasma. Exclu\u00eddas as causas iatrog\u00eanicas, a causa mais comum da S\u00edndrome de Cushing \u00e9 a Doen\u00e7a de Cushing, acometendo cerca de 70% dos casos. Apresentamos o caso de um paciente de 20 anos, masculino, com obesidade centr\u00edpeta, face de \"lua-cheia\" e estrias p\u00farpuricas, cuja investiga\u00e7\u00e3o diagn\u00f3stica demostrou tratar-se de macroadenoma hipofis\u00e1rio. O paciente foi submetido \u00e0 hipofisectomia transesfenoidal, entretanto evoluiu com recidiva precoce do quadro cl\u00ednico, sendo submetido a novo procedimento cir\u00fargico seguido de radioterapia. O paciente encontra-se atualmente em remiss\u00e3o cl\u00ednico-laboratorial.<\/jats:p>","DOI":"10.1590\/s0004-27302004000600020","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T20:05:13Z","timestamp":1115928313000},"page":"909-912","source":"Crossref","is-referenced-by-count":2,"title":["Doen\u00e7a de Cushing por macroadenoma hipofis\u00e1rio"],"prefix":"10.1590","volume":"48","author":[{"given":"Ant\u00f4nio C.","family":"Rubatino Jr","sequence":"first","affiliation":[{"name":"Hospital dos Servidores do Estado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Ferreira","family":"Pereira","sequence":"additional","affiliation":[{"name":"Hospital dos Servidores do Estado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Benchimol","sequence":"additional","affiliation":[{"name":"Hospital dos Servidores do Estado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg Christa","family":"Laun","sequence":"additional","affiliation":[{"name":"Hospital dos Servidores do Estado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Endocrinologia cl\u00ednica","first-page":"363","volume-title":"Diagn\u00f3stico e diagn\u00f3stico diferencial da S\u00edndrome de Cushing","author":"Vilar L","year":"1999"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1056\/NEJM199503233321207","article-title":"Cushing's syndrome","volume":"332","author":"Orth D","year":"1995","journal-title":"N Engl J Med","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0889-8529(05)70280-2","article-title":"Clinical and biochemical evaluation of Cushing's syndrome","volume":"26","author":"Meier CA","year":"1997","journal-title":"Endocrinol Metab Clin North Am","ISSN":"https:\/\/id.crossref.org\/issn\/0889-8529","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1365-2265.1995.tb02918.x","article-title":"A single sleeping midnight cortisol has 100% sensitivity for the diagnosis of Cushing's syndrome","volume":"43","author":"Newell-Price J","year":"1995","journal-title":"Clin Endocrinol (Oxf)","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"key":"ref5","article-title":"Establishing the cause of Cushing's syndrome II","author":"Orth D","year":"2002","journal-title":"Up To Date"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1590\/S0004-27302000000600004","article-title":"Tratamento medicamentoso dos tumores hipofis\u00e1rios Parte II: Adenomas secretores de ACTH, TSH e clinicamente n\u00e3o funcionantes","volume":"44","author":"Vilar L","year":"2000","journal-title":"Arq Bras Endocrinol Metab"},{"key":"ref7","article-title":"Primary therapy of Cushing's disease: transsphenoidal surgery and pituitary irradiation","author":"Orth D","year":"2002","journal-title":"Up To Date"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1056\/NEJM199701163360303","article-title":"The long-term outcome of pituitary irradiation after unsuccessful transsphenoidal surgery in Cushing's disease","volume":"336","author":"Estrada J","year":"1997","journal-title":"N Engl J Med","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"}],"container-title":["Arquivos Brasileiros de Endocrinologia &amp; Metabologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abem\/v48n6\/a20v48n6.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T06:17:02Z","timestamp":1495693022000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-27302004000600020&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S0004-27302004000600020"],"URL":"https:\/\/doi.org\/10.1590\/s0004-27302004000600020","relation":{},"ISSN":["0004-2730"],"issn-type":[{"value":"0004-2730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}