{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:30:56Z","timestamp":1787959856296,"version":"build-2784847793"},"reference-count":119,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p>Na mulher, os androg\u00eanios decrescem lenta e progressivamente a partir da quarta d\u00e9cada e por toda a vida. O decl\u00ednio dos androg\u00eanios pode gerar um estado de defici\u00eancia que se manifesta insidiosamente por diminui\u00e7\u00e3o da fun\u00e7\u00e3o sexual, bem estar e energia, altera\u00e7\u00f5es na composi\u00e7\u00e3o corporal e perda de massa \u00f3ssea. Se h\u00e1 hist\u00f3ria de ooforectomia bilateral, pan-hipopituitarismo, supress\u00e3o da androg\u00eanese adrenal e\/ou os n\u00edveis s\u00e9ricos de testosterona biodispon\u00edvel se encontram reduzidos, \u00e9 prov\u00e1vel que estes sinais e sintomas sejam aliviados pela administra\u00e7\u00e3o criteriosa de androg\u00eanios, cuja pr\u00e1tica tem se difundido. Nas doses atualmente preconizadas, parece que os benef\u00edcios sobre massa \u00f3ssea, sexualidade e qualidade de vida s\u00e3o alcan\u00e7ados sem importantes efeitos colaterais de viriliza\u00e7\u00e3o. Entretanto, trabalhos bem controlados s\u00e3o necess\u00e1rios para validar a hip\u00f3tese de que a administra\u00e7\u00e3o terap\u00eautica de androg\u00eanios em mulheres n\u00e3o tem, a longo prazo, repercuss\u00f5es significativas na incid\u00eancia sobre c\u00e2ncer de mama ou conseq\u00fc\u00eancias metab\u00f3licas indesej\u00e1veis.<\/jats:p>","DOI":"10.1590\/s0004-27302005000200006","type":"journal-article","created":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T13:15:14Z","timestamp":1136812514000},"page":"205-216","source":"Crossref","is-referenced-by-count":3,"title":["Insufici\u00eancia androg\u00eanica na mulher e potenciais riscos da reposi\u00e7\u00e3o terap\u00eautica"],"prefix":"10.1590","volume":"49","author":[{"given":"Lenora M.C.S.M.","family":"Le\u00e3o","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro; Universidade Federal do Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica 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