{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T19:20:12Z","timestamp":1769282412762,"version":"3.49.0"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p>Inicialmente empregadas para mensura\u00e7\u00e3o de sintomas \u00e1lgicos, as escalas visuais anal\u00f3gicas (EVAs) podem ser tamb\u00e9m um instrumento \u00fatil para avalia\u00e7\u00e3o da saciedade. O agente antiobesidade sibutramina, ao contr\u00e1rio dos anorex\u00edgenos, parece exercer seu efeito de redu\u00e7\u00e3o de ingest\u00e3o alimentar principalmente por est\u00edmulo da saciedade. Com o objetivo de avaliar o efeito da sibutramina sobre a saciedade, utilizamos uma EVA em adolescentes obesos que participaram de um estudo duplo-cego randomizado, comparando sibutramina 10mg com placebo. Cada paciente recebeu 13 escalas para serem preenchidas em intervalos de uma hora, num \u00fanico dia, das 9 \u00e0s 21h. Uma dieta com d\u00e9ficit de 500kcal di\u00e1rias foi dividida em 3 refei\u00e7\u00f5es, com hor\u00e1rios previamente estipulados: 9:30h, 12:30h, 18:30h. A partir da pontua\u00e7\u00e3o obtida em cada uma das escalas, construiu-se um gr\u00e1fico de linha representativo da pontua\u00e7\u00e3o m\u00e9dia de saciedade ao longo do dia. Comparando-se a \u00e1rea sob a curva dos 2 grupos, encontramos 4.609 \u00b1 1.309 para o grupo tratado com sibutramina e 4.141 \u00b1 1.432 para o grupo placebo (p= NS). Desta forma, a sibutramina n\u00e3o parece apresentar efeito sobre a saciedade de adolescentes obesos, pelo menos quando avaliado atrav\u00e9s de uma EVA.<\/jats:p>","DOI":"10.1590\/s0004-27302005000200016","type":"journal-article","created":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T18:15:14Z","timestamp":1136830514000},"page":"286-290","source":"Crossref","is-referenced-by-count":7,"title":["Avalia\u00e7\u00e3o do efeito da sibutramina sobre a saciedade por escala visual anal\u00f3gica em adolescentes obesos"],"prefix":"10.1590","volume":"49","author":[{"given":"L\u00edvia L.","family":"Corr\u00eaa","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Jane"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique W.","family":"Platt","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de 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