{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:58:12Z","timestamp":1761742692923},"reference-count":21,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p>O teste da clonidina \u00e9 amplamente usado para avaliar a secre\u00e7\u00e3o do horm\u00f4nio do crescimento. Os efeitos colaterais s\u00e3o sonol\u00eancia (35%) e hipotens\u00e3o arterial (HA) (5%). Nossos objetivos foram avaliar a toler\u00e2ncia ao teste quanto \u00e0 queda da press\u00e3o arterial (PA), grau de seda\u00e7\u00e3o e efic\u00e1cia da expans\u00e3o vol\u00eamica para controle da HA. A PA foi medida nos tempos basal, 60 e 120 min. A seda\u00e7\u00e3o foi baseada na escala Ramsay. Os pacientes foram divididos em dois grupos: o Grupo 1 (n= 80) recebeu expans\u00e3o vol\u00eamica apenas com HA grave (queda da PA m\u00e9dia [PAM] &gt; 20% da PAM inicial) e\/ou hipotens\u00e3o postural; o Grupo 2 (n=100) recebeu expans\u00e3o vol\u00eamica desde o in\u00edcio do teste. Nos dois grupos, a PAM caiu significativamente e 75% apresentaram sonol\u00eancia aos 60 min. N\u00e3o houve correla\u00e7\u00e3o da queda da PAM com grau de seda\u00e7\u00e3o e dose administrada. O Grupo 1 apresentou mais hipotens\u00e3o (59% x 28%) e maior queda da PAM aos 60 min. Apenas um paciente apresentou broncoespasmo. Conclu\u00edmos que o efeito hipotensor da clonidina diminui com expans\u00e3o vol\u00eamica desde o in\u00edcio no teste. Este teste deve ser sempre feito com acompanhamento m\u00e9dico especializado para observa\u00e7\u00e3o estrita da PA e interven\u00e7\u00e3o precoce, se necess\u00e1ria.<\/jats:p>","DOI":"10.1590\/s0004-27302005000400007","type":"journal-article","created":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T17:34:43Z","timestamp":1136828083000},"page":"510-515","source":"Crossref","is-referenced-by-count":3,"title":["Toler\u00e2ncia ao teste da clonidina em 180 pacientes: estudo da efic\u00e1cia da expans\u00e3o vol\u00eamica para o controle de hipotens\u00e3o arterial"],"prefix":"10.1590","volume":"49","author":[{"given":"Suemi","family":"Marui","sequence":"first","affiliation":[{"name":"Fleury - Centro de Medicina Diagn\u00f3stica e Instituto Fleury; Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia H.M.C.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Fleury - Centro de Medicina Diagn\u00f3stica e Instituto Fleury"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00edlvia C.A.L.","family":"Souza","sequence":"additional","affiliation":[{"name":"Fleury - Centro de Medicina Diagn\u00f3stica e Instituto Fleury"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Berger","sequence":"additional","affiliation":[{"name":"Fleury - Centro de Medicina Diagn\u00f3stica e Instituto Fleury; Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Khawali","sequence":"additional","affiliation":[{"name":"Fleury - Centro de Medicina Diagn\u00f3stica e Instituto Fleury"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar M.","family":"Hauache","sequence":"additional","affiliation":[{"name":"Fleury - Centro de Medicina Diagn\u00f3stica e Instituto Fleury; Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui M.B.","family":"Maciel","sequence":"additional","affiliation":[{"name":"Fleury - Centro de Medicina Diagn\u00f3stica e Instituto Fleury; Universidade Federal de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Gilberto H.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Fleury - Centro de Medicina Diagn\u00f3stica e Instituto Fleury; Universidade Federal de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0140-6736(79)90293-9","article-title":"Oral clonidine as a growth hormone stimulation test.","volume":"2","author":"Gil-Ad I","year":"1979","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref2","series-title":"Williams\u2019 textbook of endocrinology","first-page":"1003","volume-title":"Normal and aberrant growth","author":"Reiter EO","year":"2003","edition":"10"},{"key":"ref3","first-page":"3990","article-title":"Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society","volume":"85","year":"2000","journal-title":"J Clin Endocrinol Metab","ISSN":"http:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1210\/endo-114-5-1950","article-title":"Evidence that opiatergic and alpha-adrenergic mechanisms stimulate rat growth hormone release via growth hormone-releasing factor (GRF).","volume":"114","author":"Miki N","year":"1984","journal-title":"Endocrinology","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1210\/jcem-73-2-251","article-title":"Evidence that alpha 2-adrenergic pathways play a major role in growth hormone (GH) neuroregulation: alpha 2-adrenergic agonism counteracts the inhibitory effect of muscarinic cholinergic receptor blockade on the GH response to GH-releasing hormone, while alpha 2-adrenergic blockade diminishes the potentiating effect of increased cholinergic tone on such stimulation in normal men.","volume":"73","author":"Devesa J","year":"1991","journal-title":"J Clin Endocrinol Metab","ISSN":"http:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref6","series-title":"Goodman and Gilman\u2019s the pharmacological basis of therapeutics.","first-page":"315","volume-title":"Catecholamines, sympathomimetic drugs, and adrenergic receptor antagonists","author":"Hoffman BB.","year":"2001","edition":"10"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/j.1552-4604.1989.tb03378.x","article-title":"Relationship of plasma clonidine to growth hormone concentrations in children and adolescents","volume":"29","author":"Hoffman WH","year":"1989","journal-title":"J Clin Pharmacol","ISSN":"http:\/\/id.crossref.org\/issn\/0091-2700","issn-type":"print"},{"key":"ref8","first-page":"3323","article-title":"Reliability of provocative tests to assess growth hormone secretory status.: Study in 472 normally growing children.","volume":"81","author":"Ghigo E","year":"1996","journal-title":"J Clin Endocrinol Metab","ISSN":"http:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1136\/bmj.2.5920.656","article-title":"Controlled sedation with alphaxalone-alphadolone.","volume":"2","author":"Ramsay MA","year":"1974","journal-title":"Br Med J","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1447","issn-type":"print"},{"key":"ref10","first-page":"293","article-title":"Monoclonal antibody-based immunoenzymometric assay for serum human growth hormone.","volume":"23","author":"Vieira JG","year":"1990","journal-title":"Braz J Med Biol Res","ISSN":"http:\/\/id.crossref.org\/issn\/0100-879X","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1046\/j.1440-1754.1998.t01-1-00217.x","article-title":"Clonidine poisoning - an emerging problem: epidemiology, clinical features, management and preventative strategies","volume":"34","author":"Erickson SJ","year":"1998","journal-title":"J Paediatr Child Health","ISSN":"http:\/\/id.crossref.org\/issn\/1034-4810","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1097\/00003246-199010000-00014","article-title":"Critical care for clonidine poisoning in toddlers","volume":"18","author":"Fiser DH","year":"1990","journal-title":"Crit Care Med","ISSN":"http:\/\/id.crossref.org\/issn\/0090-3493","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01061368","article-title":"Pharmacokinetic and pharmacodynamic studies of oral clonidine in normotensive subjects.","volume":"23","author":"Anavekar SN","year":"1982","journal-title":"Eur J Clin Pharmacol","ISSN":"http:\/\/id.crossref.org\/issn\/0031-6970","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF03349059","article-title":"Tolerance of the oral clonidine test in 75 pediatric patients.","volume":"11","author":"De Angelis R","year":"1988","journal-title":"J Endocrinol Invest","ISSN":"http:\/\/id.crossref.org\/issn\/0391-4097","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0022-3476(87)80123-3","article-title":"Low-dose oral clonidine: effective growth hormone releasing agent in children but not in adolescents.","volume":"111","author":"Batista MC","year":"1987","journal-title":"J Pediatr","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3476","issn-type":"print"},{"key":"ref16","first-page":"229","article-title":"GH values after clonidine stimulation measured by immunofluorometric assay in normal prepubertal children and GH-deficient patients.","volume":"59","author":"Silva EG","year":"2003","journal-title":"Horm Res","ISSN":"http:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1177\/000992289303201111","article-title":"Hypoglycemia due to sedation following clonidine test for growth hormone reserve","volume":"32","author":"Sridhar GR.","year":"1993","journal-title":"Clin Pediatr (Phila)","ISSN":"http:\/\/id.crossref.org\/issn\/0009-9228","issn-type":"print"},{"key":"ref18","first-page":"451","article-title":"Seizures following clonidine test for growth hormone reserve:unusual presentation of benign partial epilepsy.","volume":"13","author":"Scaramuzza A","year":"2000","journal-title":"J Pediatr Endocrinol Metab","ISSN":"http:\/\/id.crossref.org\/issn\/0334-018X","issn-type":"print"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1542\/peds.108.2.471","article-title":"A 1000-fold overdose of clonidine caused by a compounding error in a 5-year-old child with attention-deficit\/hyperactivity disorder.","volume":"108","author":"Romano MJ","year":"2001","journal-title":"Pediatrics","ISSN":"http:\/\/id.crossref.org\/issn\/0031-4005","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00006565-200208000-00014","article-title":"Pediatric clonidine poisoning as a result of pharmacy compounding error.","volume":"18","author":"Suchard JR","year":"2002","journal-title":"Pediatr Emerg Care","ISSN":"http:\/\/id.crossref.org\/issn\/0749-5161","issn-type":"print"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.1007\/BF00442460","article-title":"Asthmatic attack associated with oral clonidine test.","volume":"142","author":"Ashkenazi S","year":"1984","journal-title":"Eur J Pediatr","ISSN":"http:\/\/id.crossref.org\/issn\/0340-6199","issn-type":"print"}],"container-title":["Arquivos Brasileiros de Endocrinologia &amp; Metabologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abem\/v49n4\/a07v49n4.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T09:32:47Z","timestamp":1495704767000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-27302005000400007&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0004-27302005000400007"],"URL":"https:\/\/doi.org\/10.1590\/s0004-27302005000400007","relation":{},"ISSN":["0004-2730"],"issn-type":[{"value":"0004-2730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}