{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T13:16:53Z","timestamp":1665407813092},"reference-count":36,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>Carcinoma de paratir\u00f3ide \u00e9 uma condi\u00e7\u00e3o rara, correspondendo na maior parte das casu\u00edsticas a menos de 1% dos casos de hiperparatiroidismo prim\u00e1rio (HPP). No entanto, pela sua gravidade, e com o progn\u00f3stico dependente do diagn\u00f3stico precoce e de uma conduta agressiva, \u00e9 fundamental que a suspeita cl\u00ednica seja feita pr\u00e9-operatoriamente. As caracter\u00edsticas cl\u00ednicas s\u00e3o compat\u00edveis com um caso de HPP grave, sintom\u00e1tico, com tumor cervical &gt;1,5cm, podendo ser palp\u00e1vel. A defini\u00e7\u00e3o an\u00e1tomo-patol\u00f3gica pode ser dif\u00edcil em muitos casos. Nossa casu\u00edstica (1983-2004) compreende 7 casos, todos sintom\u00e1ticos, com s\u00edndrome hipercalc\u00eamica e doen\u00e7a \u00f3ssea presente na maioria. Em 6\/7 o tumor era palp\u00e1vel, e todos apresentavam quadro bioqu\u00edmico compat\u00edvel. Tr\u00eas pacientes faleceram em quadro de hipercalcemia refrat\u00e1ria. Dados recentes apontam para uma muta\u00e7\u00e3o no gene HRPT2 como base molecular para o desenvolvimento destes tumores. A conduta \u00e9 cir\u00fargica e deve incluir hemitiroidectomia e explora\u00e7\u00e3o cervical ampliada, procurando focos metast\u00e1ticos. O p\u00f3s-operat\u00f3rio \u00e9 compat\u00edvel com a gravidade da altera\u00e7\u00e3o metab\u00f3lica pr\u00e9-existente, sendo comum a tend\u00eancia a hipocalcemia. O progn\u00f3stico de longo prazo depende do diagn\u00f3stico precoce, do sucesso cir\u00fargico e do controle da hipercalcemia. Novas possibilidades terap\u00eauticas, na forma de bisfosfonatos e drogas calcimim\u00e9ticas, bem como a possibilidade de diagn\u00f3stico gen\u00e9tico, tendem a melhorar o progn\u00f3stico desta grave condi\u00e7\u00e3o.<\/jats:p>","DOI":"10.1590\/s0004-27302005000500023","type":"journal-article","created":{"date-parts":[[2006,2,10]],"date-time":"2006-02-10T14:05:59Z","timestamp":1139580359000},"page":"811-815","source":"Crossref","is-referenced-by-count":7,"title":["Carcinoma de paratir\u00f3ide"],"prefix":"10.1590","volume":"49","author":[{"given":"Jos\u00e9 Gilberto H.","family":"Vieira","sequence":"first","affiliation":[{"name":"Escola Paulista de Medicina; Instituto Fleury"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique N.","family":"Ohe","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar M.","family":"Hauache","sequence":"additional","affiliation":[{"name":"Instituto Fleury"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulisses Maia de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janaina Martins","family":"Delana","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marise","family":"Lazaretti-Castro","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"26","key":"ref1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/hed.20049","article-title":"Parathyroid carcinoma: A 22-year experience","author":"Busaidy NL","year":"2004","journal-title":"Head Neck","ISSN":"http:\/\/id.crossref.org\/issn\/1043-3074","issn-type":"print"},{"issue":"86","key":"ref2","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/(SICI)1097-0142(19990801)86:3<538::AID-CNCR25>3.0.CO;2-K","article-title":"Two hundred eighty-six cases of parathyroid carcinoma treated in the US between 1985-1995: a National Cancer Data Base Report. 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