{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:15:09Z","timestamp":1761822909112},"reference-count":44,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>A radioterapia resulta em endocrinopatias, osteoporose, obesidade e seq\u00fcelas neurol\u00f3gicas em pacientes tratados por c\u00e2ncer. A defici\u00eancia de GH \u00e9 a complica\u00e7\u00e3o mais freq\u00fcente no eixo hipot\u00e1lamo-hipofis\u00e1rio. A freq\u00fc\u00eancia, prazo de surgimento e gravidade da defici\u00eancia de GH dependem da dose recebida durante a irradia\u00e7\u00e3o craniana, mas idade \u00e0 radioterapia e fracionamento da dose tamb\u00e9m s\u00e3o vari\u00e1veis importantes. Outras anormalidades do eixo hipot\u00e1lamo-hipofis\u00e1rio s\u00e3o igualmente dose-dependentes. Baixas doses de irradia\u00e7\u00e3o induzem puberdade precoce ou avan\u00e7ada, enquanto altas doses provocam defici\u00eancia gonadotr\u00f3pica. Complica\u00e7\u00f5es end\u00f3crinas secund\u00e1rias \u00e0 irradia\u00e7\u00e3o perif\u00e9rica, como dist\u00farbios gonadais ou tireoidianos s\u00e3o descritos. Mesmo com secre\u00e7\u00e3o normal de GH, o crescimento pode ser comprometido por les\u00f5es \u00f3sseas ap\u00f3s irradia\u00e7\u00e3o corporal total ou cr\u00e2nio-espinhal. Resultados melhores sobre a estatura final t\u00eam sido obtidos com reposi\u00e7\u00e3o de GH em associa\u00e7\u00e3o com o tratamento da puberdade precoce ou avan\u00e7ada. O objetivo desta revis\u00e3o \u00e9 a abordagem das seq\u00fcelas end\u00f3crinas tardias da radioterapia.<\/jats:p>","DOI":"10.1590\/s0004-27302005000500025","type":"journal-article","created":{"date-parts":[[2006,2,10]],"date-time":"2006-02-10T14:05:59Z","timestamp":1139580359000},"page":"825-832","source":"Crossref","is-referenced-by-count":7,"title":["Seq\u00fcelas end\u00f3crinas da radioterapia no tratamento do c\u00e2ncer na inf\u00e2ncia e adolesc\u00eancia"],"prefix":"10.1590","volume":"49","author":[{"given":"Ana Cl\u00e1udia","family":"Couto-Silva","sequence":"first","affiliation":[{"name":"Universidade Federal da Bahia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Brauner","sequence":"additional","affiliation":[{"name":"Universidade Paris V, Fran\u00e7a"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds Fernando","family":"Adan","sequence":"additional","affiliation":[{"name":"Universidade Federal da 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