{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:08:38Z","timestamp":1777622918591,"version":"3.51.4"},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p>O magn\u00e9sio \u00e9 um \u00edon predominantemente intra-celular, que participa como co-fator de mais de 300 rea\u00e7\u00f5es enzim\u00e1ticas, dentre elas na atividade da tirosino-cinase. Sua defici\u00eancia pode aumentar a resist\u00eancia perif\u00e9rica \u00e0 insulina, especialmente em pacientes com s\u00edndrome metab\u00f3lica e diabetes mellitus tipo 2 (DM2). Este trabalho avaliou, em 27 pacientes com DM2 descompensado, o conte\u00fado intra-celular de magn\u00e9sio, correlacionando-o com \u00edndices laboratoriais de resist\u00eancia insul\u00ednica e controle glic\u00eamico. Hipomagnesemia foi encontrada em 75% dos pacientes e d\u00e9ficit intra-celular em 30,8%. Houve correla\u00e7\u00e3o negativa do Mg intra-celular (Mg IC) com HbA1 e com IMC. 59,2% dos pacientes apresentaram HOMA IR &gt; 3,5, e tend\u00eancia para correla\u00e7\u00e3o negativa com o Mg IC, por\u00e9m sem signific\u00e2ncia estat\u00edstica. Apesar do n\u00famero pequeno de pacientes, ressalta-se que uma vez que defici\u00eancia de magn\u00e9sio \u00e9 comum em pacientes com diabetes, sua rela\u00e7\u00e3o com resist\u00eancia insul\u00ednica deve ser mais estudada.<\/jats:p>","DOI":"10.1590\/s0004-27302005000600016","type":"journal-article","created":{"date-parts":[[2006,4,19]],"date-time":"2006-04-19T13:59:50Z","timestamp":1145455190000},"page":"959-963","source":"Crossref","is-referenced-by-count":12,"title":["Defici\u00eancia de magn\u00e9sio e resist\u00eancia \u00e0 insulina em pacientes com diabetes mellitus tipo 2"],"prefix":"10.1590","volume":"49","author":[{"given":"Maria de Lourdes","family":"Lima","sequence":"first","affiliation":[{"name":"Universidade Federal da Bahia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Pousada","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynara","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomaz","family":"Cruz","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"464","article-title":"Selected vitamins and minerals in diabetes","volume":"17","author":"Mooradian A","year":"1994","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0098-2997(02)00090-0","article-title":"Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X","volume":"24","author":"Barbagallo M","year":"2003","journal-title":"Mol Aspec Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2337\/diacare.26.4.1147","article-title":"Oral Magnesium Supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects","volume":"26","author":"Rodriguez-Moran M","year":"2003","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0009-8981(79)90364-4","article-title":"Hypomagnesemia in diabetes","volume":"95","author":"Mather H","year":"1979","journal-title":"Clin Chem Acta"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF00251280","article-title":"Tissue magnesium status in diabetes mellitu","volume":"21","author":"Levin G","year":"1981","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-2362.1982.tb00942.x","article-title":"Renal hypomagnesemia in human diabetes mellitus: its relation to glucose homeostasis","volume":"12","author":"McNair P","year":"1982","journal-title":"Eur J Clin Invest","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2972","issn-type":"print"},{"key":"ref7","first-page":"173","article-title":"Trastorno electivo en transporte tubular renal de magnesio en la diabetes mellitus","volume":"169","author":"Herrera Pombo J","year":"1983","journal-title":"Rev Clin Espan"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF02590769","article-title":"Serum and erythrocyte magnesium level in type I and type II diabetics","volume":"22","author":"Vanroelen L","year":"1985","journal-title":"Acta Diabetol","ISSN":"https:\/\/id.crossref.org\/issn\/0940-5429","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/BF00401149","article-title":"Intracellular and extracellular magnesium depletion in type 2 (non-insulin dependent) diabetes mellitus","volume":"36","author":"Resnick L","year":"1993","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"key":"ref10","author":"Lima ML","year":"1995"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"682","DOI":"10.2337\/diacare.21.5.682","article-title":"The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes","volume":"21","author":"Lima ML","year":"1998","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1001\/archinte.159.18.2151","article-title":"Serum and dietary magnesium and the risk of type 2 diabetes mellitus and atherosclerose risk in community study","volume":"159","author":"Kao WH","year":"1999","journal-title":"Arch Intern Med","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9926","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2337\/diacare.27.1.59","article-title":"Dietary Magnesium Intake in relation to plasma insulin levels and risk of type 2 diabetes in Women","volume":"27","author":"Song Y","year":"2004","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1136\/bmj.327.7406.61","article-title":"The Metabolic Syndrome","volume":"327","author":"Meigs JB","year":"2003","journal-title":"BMJ","ISSN":"https:\/\/id.crossref.org\/issn\/0959-8138","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"602","DOI":"10.2337\/diacare.27.2.602","article-title":"The 1st World Congress on the Insulin Resistance Syndrome","volume":"27","author":"Bloomgarden Z","year":"2004","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/sj.ejcn.1601350","article-title":"Insulin resistance and the metabolic syndrome: a challenge of the new millennium","volume":"56","author":"Hauner H","year":"2002","journal-title":"Eur J Clin Nutr","ISSN":"https:\/\/id.crossref.org\/issn\/0954-3007","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.2337\/diacare.26.11.3180","article-title":"The coming of age of the metabolic syndrome","volume":"26","author":"Alexander C","year":"2003","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s005920200036","article-title":"Low serum magnesium levels and metabolic syndrome","volume":"39","author":"Guerrero-Romero F","year":"2002","journal-title":"Acta Diabetologica","ISSN":"https:\/\/id.crossref.org\/issn\/0940-5429","issn-type":"print"},{"key":"ref19","series-title":"Sponsored workshop on human B and T cell","volume-title":"Identification, enumeration and isolation of B and T lymphocytes from human peripheral blood","year":"1974"},{"key":"ref20","first-page":"1","article-title":"Modifica\u00e7\u00e3o do m\u00e9todo de Lowry para a quantifica\u00e7\u00e3o de prote\u00ednas","volume":"25","author":"Rodrigues LEA","year":"1989","journal-title":"Rev Bras Patol Cl\u00edn"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Mathews DR","year":"1985","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1210\/jcem.86.10.7952","article-title":"Limitations if the fasting glucose to insulin ratio as an index of insulin sensitivity (editorial)","volume":"86","author":"Quon MJ","year":"2001","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0009-8981(87)90371-8","article-title":"Intracellular magnesium of mononuclear cells from venous blood of clinically health subjects","volume":"167","author":"Reinhart R","year":"1987","journal-title":"Clin Chem Acta"},{"key":"ref24","series-title":"Comportamento do magn\u00e9sio linfocit\u00e1rio e plasm\u00e1tico no infarto agudo do mioc\u00e1rdio","author":"Menezes M","year":"1985"},{"key":"ref25","first-page":"77","article-title":"Measurements of magnesium in mononuclear cells","volume":"42","author":"Sj\u00f6gren AS","year":"1985","journal-title":"Sci Environ"},{"key":"ref26","first-page":"49","article-title":"Muscle magnesium content and cardiac arrhytmias during treatment of congestive heart failure due to chronic chagasic cardiomyopathy","volume":"19","author":"C\u00e2mara EM","year":"1996","journal-title":"Braz J Med Biol Res","ISSN":"https:\/\/id.crossref.org\/issn\/0100-879X","issn-type":"print"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2337\/diacare.12.4.265","article-title":"Improved insulin response and action by chronic magnesium administration in aged NIDDM subjects","volume":"12","author":"Paolisso G","year":"1989","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.2337\/diacare.19.10.1138","article-title":"A prospective analysis of the HOMA model","volume":"19","author":"Hafner S","year":"1996","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.2337\/diacare.15.8.1065","article-title":"Magnesium supplementation in the treatment of diabetes","volume":"15","year":"1992","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1530\/acta.0.1210016","article-title":"Dietary magnesium supplements improve b cell response to glucose and arginine in elderly non-insulin dependent diabetic subject","volume":"121","author":"Paolisso G","year":"1989","journal-title":"Acta Endocrinol (Copenh)","ISSN":"https:\/\/id.crossref.org\/issn\/0001-5598","issn-type":"print"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"460","DOI":"10.2337\/diacare.17.5.460","article-title":"Effect of magnesium treatment on glycemic control and metabolic parameters in NIDDM patients","volume":"17","author":"Gullestad L","year":"1994","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"188","DOI":"10.2337\/diacare.18.2.188","article-title":"Hypomagnesemia in type II diabetes: effect of a 3-month replacement therapy","volume":"18","author":"Eibl NL","year":"1995","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"}],"container-title":["Arquivos Brasileiros de Endocrinologia &amp; Metabologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abem\/v49n6\/27398.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T03:28:14Z","timestamp":1555558094000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-27302005000600016&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S0004-27302005000600016"],"URL":"https:\/\/doi.org\/10.1590\/s0004-27302005000600016","relation":{},"ISSN":["0004-2730"],"issn-type":[{"value":"0004-2730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}