{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:24:28Z","timestamp":1773408268723,"version":"3.50.1"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p>Nos \u00faltimos anos, no Brasil e em pa\u00edses do mundo desenvolvido, a obesidade se tornou um problema de sa\u00fade p\u00fablica mais importante que a desnutri\u00e7\u00e3o. Com o aumento de preval\u00eancia de obesidade, identificou-se que, al\u00e9m do DM2 e da s\u00edndrome metab\u00f3lica, outras entidades cl\u00ednicas tamb\u00e9m estavam associadas \u00e0 resist\u00eancia \u00e0 insulina. Nesta revis\u00e3o, abordaremos algumas destas altera\u00e7\u00f5es, com destaque para a doen\u00e7a hep\u00e1tica gordurosa n\u00e3o alco\u00f3lica, mas incluindo tamb\u00e9m a SOP, a hiperuricemia, a doen\u00e7a renal cr\u00f4nica, a insufici\u00eancia card\u00edaca, altera\u00e7\u00f5es cognitivas e c\u00e2ncer.<\/jats:p>","DOI":"10.1590\/s0004-27302006000200022","type":"journal-article","created":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T11:18:35Z","timestamp":1155122315000},"page":"360-367","source":"Crossref","is-referenced-by-count":16,"title":["Doen\u00e7as associadas \u00e0 resist\u00eancia \u00e0 insulina\/hiperinsulinemia, n\u00e3o inclu\u00eddas na s\u00edndrome metab\u00f3lica"],"prefix":"10.1590","volume":"50","author":[{"given":"Jos\u00e9 B.C.","family":"Carvalheira","sequence":"first","affiliation":[{"name":"UNICAMP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario 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